Multimodal transition and stochastic antiresonance in squid giant axons

The experimental data of N. Takahashi, Y. Hanyu, T. Musha, R. Kubo, and G. Matsumoto, Physica D \textbf{43}, 318 (1990), on the response of squid giant axons stimulated by periodic sequence of short current pulses is interpreted within the Hodgkin-Huxley model. The minimum of the firing rate as a function of the stimulus amplitude $I_0$ in the high-frequency regime is due to the multimodal transition. Below this singular point only odd multiples of the driving period remain and the system is highly sensitive to noise. The coefficient of variation has a maximum and the firing rate has a minimum as a function of the noise intensity which is an indication of the stochastic coherence antiresonance. The model calculations reproduce the frequency of occurrence of the most common modes in the vicinity of the transition. A linear relation of output frequency vs. $I_0$ for above the transition is also confirmed.Comment: 5 pages, 9 figure

Detection of subthreshold pulses in neurons with channel noise

Neurons are subject to various kinds of noise. In addition to synaptic noise, the stochastic opening and closing of ion channels represents an intrinsic source of noise that affects the signal processing properties of the neuron. In this paper, we studied the response of a stochastic Hodgkin-Huxley neuron to transient input subthreshold pulses. It was found that the average response time decreases but variance increases as the amplitude of channel noise increases. In the case of single pulse detection, we show that channel noise enables one neuron to detect the subthreshold signals and an optimal membrane area (or channel noise intensity) exists for a single neuron to achieve optimal performance. However, the detection ability of a single neuron is limited by large errors. Here, we test a simple neuronal network that can enhance the pulse detecting abilities of neurons and find dozens of neurons can perfectly detect subthreshold pulses. The phenomenon of intrinsic stochastic resonance is also found both at the level of single neurons and at the level of networks. At the network level, the detection ability of networks can be optimized for the number of neurons comprising the network.Comment: 14 pages, 9 figure

The Gravitomagnetic Influence on Gyroscopes and on the Lunar Orbit

Gravitomagnetism--a motional coupling of matter analogous to the Lorentz force in electromagnetism--has observable consequences for any scenario involving differing mass currents. Examples include gyroscopes located near a rotating massive body, and the interaction of two orbiting bodies. In the former case, the resulting precession of the gyroscope is often called ``frame dragging,'' and is the principal measurement sought by the Gravity Probe-B experiment. The latter case is realized in the earth-moon system, and the effect has in fact been confirmed via lunar laser ranging (LLR) to approximately 0.1% accuracy--better than the anticipated accuracy of the Gravity-Probe-B result. This paper shows the connnection between these seemingly disparate phenomena by employing the same gravitomagnetic term in the equation of motion to obtain both gyroscopic precession and modification of the lunar orbit. Since lunar ranging currently provides a part in a thousand fit to the gravitomagnetic contributions to the lunar orbit, this feature of post-Newtonian gravity is not adjustable to fit any anomalous result beyond the 0.1% level from Gravity Probe-B without disturbing the existing fit of theory to the 36 years of LLR data.Comment: 4 pages; accepted for publication in Physical Review Letter

Comparative study of design: application to Engineering Design

A recent exploratory study examines design processes across domains and compares them. This is achieved through a series of interdisciplinary, participative workshops. A systematic framework is used to collect data from expert witnesses who are practising designers across domains from engineering through architecture to product design and fashion, including film production, pharmaceutical drugs, food, packaging, graphics and multimedia and software. Similarities and differences across domains are described which indicate the types of comparative analysis we have been able to do from our data. The paper goes further and speculates on possible lessons for selected areas of engineering design which can be drawn from comparison with processes in other domains. As such this comparative design study offers the potential for improving engineering design processes. More generally it is a first step in creating a discipline of comparative design which aims to provide a new rich picture of design processes

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process. To determine which Ets factors are the targets of Ras signaling pathways, the abilities of several Ets factors to activate Ras-responsive enhancer (RRE) reporters in the presence of oncogenic Ras were examined. In transient transfection assay, reporters containing RREs composed of Ets-AP-1 binding sites could be activated 30-fold in NIH 3T3 fibroblasts and 80-fold in the macrophage-like line RAW264 by the combination of Ets1 or Ets2 and Ras but not by several other Ets factors that were tested in the assay. Ets2 and Ras also superactivated an RRE composed of Ets-Ets binding sites, but the Ets-responsive promoter of the c-fms gene was not superactivated. Mutation of a threonine residue to alanine in the conserved amino-terminal regions of Ets1 and Ets2 (threonine 38 and threonine 72, respectively) abrogated the ability of each of these proteins to superactivate reporter gene expression. Phosphoamino acid analysis of radiolabeled Ets2 revealed that Ras induced normally absent threonine-specific phosphorylation of the protein. The Ras-dependent increase in threonine phosphorylation was not observed in Ets2 proteins that had the conserved threonine 72 residue mutated to alanine or serine. These data indicate that Ets1 and Ets2 are specific nuclear targets of Ras signaling events and that phosphorylation of a conserved threonine residue is a necessary molecular component of Ras-mediated activation of these transcription factors

Brain natriuretic peptide and NT-proBNP levels reflect pulmonary artery systolic pressure in trekkers at high altitude.

Our objective was to evaluate the utility of the natriuretic peptides BNP (brain natriuretic peptide) and NT-proBNP as markers of pulmonary artery systolic pressure (PASP) in trekkers ascending to high altitude (HA). 20 participants had BNP and NT-proBNP assayed and simultaneous echocardiographic assessment of PASP performed during a trek to 5150 m. PASP increased significantly (p=0.006) with ascent from 24+/-4 to 39+/-11 mm Hg at 5150 m. At 5150 m those with a PASP>/=40 mm Hg (n=8) (versus those with PASP/=400 pg/ml) rise in NT-proBNP at 5150 m (n=4) PASP was significantly higher: 45.9+/-7.5 vs. 32.2+/-6.2 mm Hg (p=0.015). BNP and NT-proBNP may reflect elevated PASP, a central feature of high altitude pulmonary oedema, at HA

Mid-J CO Emission From NGC 891: Microturbulent Molecular Shocks in Normal Star Forming Galaxies

We have detected the CO(6-5), CO(7-6), and [CI] 370 micron lines from the nuclear region of NGC 891 with our submillimeter grating spectrometer ZEUS on the CSO. These lines provide constraints on photodissociation region (PDR) and shock models that have been invoked to explain the H_2 S(0), S(1), and S(2) lines observed with Spitzer. We analyze our data together with the H_2 lines, CO(3-2), and IR continuum from the literature using a combined PDR/shock model. We find that the mid-J CO originates almost entirely from shock-excited warm molecular gas; contributions from PDRs are negligible. Also, almost all the H_2 S(2) and half of the S(1) line is predicted to emerge from shocks. Shocks with a pre-shock density of 2x10^4 cm^-3 and velocities of 10 km/s and 20 km/s for C-shocks and J-shocks, respectively, provide the best fit. In contrast, the [CI] line emission arises exclusively from the PDR component, which is best parameterized by a density of 3.2x10^3 cm^-3 and a FUV field of G_o = 100 for both PDR/shock-type combinations. Our mid-J CO observations show that turbulence is a very important heating source in molecular clouds, even in normal quiescent galaxies. The most likely energy sources for the shocks are supernovae or outflows from YSOs. The energetics of these shock sources favor C-shock excitation of the lines.Comment: 18 pages, 2 figures, 6 tables, accepted by Ap

CO-Dark Star Formation and Black Hole Activity in 3C 368 at z = 1.131: Coeval Growth of Stellar and Supermassive Black Hole Masses

We present the detection of four far-infrared fine-structure oxygen lines, as well as strong upper limits for the CO(2-1) and [N II] 205 um lines, in 3C 368, a well-studied radio-loud galaxy at z = 1.131. These new oxygen lines, taken in conjunction with previously observed neon and carbon fine-structure lines, suggest a powerful active galactic nucleus (AGN), accompanied by vigorous and extended star formation. A starburst dominated by O8 stars, with an age of ~6.5 Myr, provides a good fit to the fine-structure line data. This estimated age of the starburst makes it nearly concurrent with the latest episode of AGN activity, suggesting a link between the growth of the supermassive black hole and stellar population in this source. We do not detect the CO(2-1) line, down to a level twelve times lower than the expected value for star forming galaxies. This lack of CO line emission is consistent with recent star formation activity if the star-forming molecular gas has low metallicity, is highly fractionated (such that CO is photodissociated through much of the clouds), or is chemically very young (such that CO has not yet had time to form). It is also possible, though we argue unlikely, that the ensemble of fine structure lines are emitted from the region heated by the AGN.Comment: 10 pages, 4 figures, 2 tables, accepted for publication in the Astrophysical Journa