928 research outputs found

    How Dutch Institutions Enhance the Adaptive Capacity of Society

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    This report examines the adaptive capacity of the institutional framework of the Netherlands to cope with the impacts of climate change. Historically, institutions have evolved incrementally to deal with existing social problems. They provide norms and rules for collective action and create continuity rather than change. However, the nature of societal problems is changing as a result of the processes of globalization and development. With the progress made in the natural sciences, we are able to predict in advance, to a certain extent, the potential environmental impacts of various human actions on society, for example, climate change. This raises some key questions: Are our institutions capable of dealing with this new knowledge about future impacts and, more importantly, with the impacts themselves? Are our institutions capable of dealing with the inherent uncertainty of the predictions

    Linear Categorical Marginal Modeling of solicited symptoms in vaccine clinical trials

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    Analysis of the occurrence of adverse events, and in particular of solicited symptoms, following vaccination is often needed for the safety and benefit-risk evaluation of any candidate vaccine, and typically involves taking repeated measurements. In this article, it is shown that Linear Categorical Marginal Models (LCMMs) are well suited to take into account the dependencies in the data arising from the repeated measurements and provide detailed and useful information for comparing safety profiles of different products while remaining relatively easy to interpret. LCMMs are presented and applied to a Phase III clinical trial of a candidate meningococcal pediatric vaccine

    Binary Models for Marginal Independence

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    Log-linear models are a classical tool for the analysis of contingency tables. In particular, the subclass of graphical log-linear models provides a general framework for modelling conditional independences. However, with the exception of special structures, marginal independence hypotheses cannot be accommodated by these traditional models. Focusing on binary variables, we present a model class that provides a framework for modelling marginal independences in contingency tables. The approach taken is graphical and draws on analogies to multivariate Gaussian models for marginal independence. For the graphical model representation we use bi-directed graphs, which are in the tradition of path diagrams. We show how the models can be parameterized in a simple fashion, and how maximum likelihood estimation can be performed using a version of the Iterated Conditional Fitting algorithm. Finally we consider combining these models with symmetry restrictions

    On predicting religion labels in microblogging networks

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    National Research Foundation (NRF) Singapore under International Research Centres in Singapore Funding Initiativ

    Classic wisdom about ways to happiness: How does it apply today?

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    __Abstract__ Since we humans have some choice in how we live our lives, there has always been ideas about what constitutes a good life. Written reflections on that subject focus typically on moral issues, but there have always been ideas about what constitutes a satisfying life. Interest in this classic wisdom is increasing today, as part of the rising concern about happiness. This begs the question of what we can learn from this ancient wisdom. Does it hold universal truth? Or are these views specific for the historical conditions from which they emerged? In this paper I consider some classic beliefs about happiness and inspect how well these apply in contemporary society. The following five beliefs are considered: 1) Happiness is found in fame and power: follow the path of the warrior. 2) Happiness is found in wealth and involvement: follow the path of the merchant. 3) Happiness is found in intellectual development: follow the path of the philosopher. 4) Happiness is found in simplicity: follow the path of the peasant. 5) Happiness is not of this world: follow the path of the monk. Each of these ways to happiness will manifest in specific behaviors and attitudes and I inspected to what extent these go together with happiness today. To do this. I selected relevant research findings from the World Database of Happiness. The classic beliefs 1 and 2 seem to apply fairly well today, but 3 and 4 not. The advice to seek happiness in other-worldly detachment (5) may have been more sensible in the brutish conditions of feudal society, in which it emerged

    Nederlandse perspectieven op de duurzaamheid van biomassa - Resultaten van interviews met stakeholders in het kader van de Biomassadialoog

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    In Dutch: Nederlandse perspectieven op de duurzaamheid van biomassa: Resultaten van de interviews met stakeholders in het kader van de Biomassadialoo
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