Teaching Resilience to People with Visual Disabilities

The objective of the research is to develop resilience in people with visual disabilities at the Technical University of Manabí. The work offers a conceptual analysis on visual disability in students. It deals with what is related to the conceptual understanding of resilience, where several authors who have studied the subject are analyzed. The resilient capacity of students with visual impairment and the importance of psychological support is analyzed. The importance of the intervention in resilience is exposed, where the content of the Manual of Intervention in Resilience of Eugenio Saavedra 2011 is analyzed. The results of the measurement of resilience are shown in the students of the Technical University of Manabí who suffer from a visual disability and the situation that could be verified after applying the work of training in resilience to said personnel. Finally, the conclusions of the work are exposed, where the relevance of the study is demonstrated and a group of recommendations is made based on the importance of the results obtained in the research

Efecto de la progesterona natural con o sin la adición de benzoato de estradiol sobre la presentación de celo, ovulación y gestación en animales tipo Bos indicus en el trópico mexicano

The effect of a intravaginal device containing 1.9 g of progesterone and one capsule of 10 mg of estradiol benzoate (EB) (CIDR-B) was evaluated in Bos indicus cattle. Upon withdrawal, calculations regarding estrous rate, ovulation and pregnancy were considered. 122 Bos índicus cows (experiment 1) and 30 heifers (experiment 2) were used and randomly divided in three groups: Group ST: 20 cows and 10 heifers without treatment, group CIDR-B-E: 51 cows and 10 heifers with the device withdrawal at 10 or 13 days respectively (CIDRB+ E:). Finally, 51 cows and 10 heifers with the device withdrawal at 10 or 13 days respectively plus an injection 24 hours late of 1 or 2 mg of EB for cows and heifers respectively. The animals were observed for oestrus detection during 96 hours continuously after CIDR-B removal. Afterwards, starting at day 17 the animals were observed twice daily for one hour each period until 90 days. The cows that showed oestrus between 0 to 47 days were artificially inseminated and open cows in oestrus between 48 to 90 days post CIDR-B withdrawal were placed with a bull. Blood samples were collected for progesterone evaluation to confirm ovulation and ovarian activity. Pregnancy diagnosis was carried out via rectal palpation and ultrasonography. Discrete variables were analysed using the exact Fisher test. Continuous variables were analysed by Student t test, and reproductive parameters in the cows were related to oestrus, ovulation and pregnancy through a CATMOD SAS general lineal model. In both experiments the group CIDR-B+E showed a high rate of oestrus 92.2 and 90.0% for cows and heifers respectively and was different (p < 0.05) to CIDR-B-E (60.8 and 50.0%) and ST (35.0 and 0.0%). In relation to ovulation, no significant difference was found between groups (p > 0.05). However, CIDR-B-E showed better rates 51.6 and 60.0% than ST group 28.6 and 30.0% and CIDR-B+E group 36.2 and 30.0%. Global pregnancy during 90 days was 25.4% in experiment 1 and 56.7 in experiment 2 (p < 0.05). However, pregnancies obtained during the 0-5 days of CIDR-B withdrawal and the next four oestrus cycles were not significantly different in the three groups (p > 0.05). Nonetheless, 83.8% and 82.3% of the pregnancies concur in the first five days after withdrawal and the next two cycles. Therefore it can be concluded that the oestradiol injection induced the presence of high number of animals in oestrus, but the ovulation rate and pregnancy rate was not improved. However, others factors influenced the results such as nutrition and suckling.Se evaluó el efecto de un dispositivo intravaginal que contiene 1.9 g de progesterona y una cápsula de 10 mg de benzoato de estradiol (BE) (CIDR-B®), seguido o no de la aplicación intramuscular de BE, a las 24 horas de retirado el dispositivo, y se observó el porcentaje de estro, ovulación y gestación. Se utilizaron 122 vacas (experimento 1) y 30 novillas (experimento 2) tipo Bos indicus, que fueron asignadas aleatoriamente a tres grupos:Grupo ST: 20 vacas y 10 novillas sin tratamiento; Grupo CIDR-BE: 51 vacas y 10 novillas con un dispositivo por 10 ó 13 días respectivamente; y Grupo CIDRB+ E: 51 vacas y 10 novillas con un dispositivo por 10 ó 13 días, además de una inyección a las 24 horas de 1 ó 2 mg de BE. La detección de estros se realizó mediante la observación visual, haciéndose durante 96 horas después de retirar el CIDR-B, y posteriormente entre los 17 a 24 días posteriores a cada período de servicios, hasta concluir los 90 días que duró el empadre. Las que presentaron estro entre los días 0 a 47 fueron servidas por IA y las que lo presentaron del 48 al 90 por monta natural. Se tomaron muestras sanguíneas para medir niveles de progesterona para corroborar ovulación. El diagnóstico de gestación se realizó por palpación rectal y ultrasonografía. Las variables categóricas se analizaron mediante la prueba exacta de Fisher y las continuas mediante t de Student. Las condiciones reproductivas previas de las vacas se relacionaron con celos, ovulación y gestación con un modelo lineal logarítmico del Proc CATMOD, SAS. En ambos experimentos el grupo CIDR-B+E presentó un alto porcentaje de estro, 92.2 y 90.0% para vacas y novillas, siendo diferente (p<0.05) a los grupos CIDR-B-E (60.8 y 50.0%) y ST (35.0 y 0.0%). En cuanto a ovulación no hubo diferencias entre grupos (p>0.05), aunque el grupo CIDR-B-E presentó mejores porcentajes, 51.6 y 60.0% contra 28.6 y 30.0% del grupo ST y 36.2 y 30.0% del grupo CIDRB+ E. La gestación global durante 90 días fue de 25.4% en el experimento 1 y 56.7% en el experimento 2 (p<0.05). A pesar de que las gestaciones obtenidas durante el período de 0-5 días de retirado el CIDR-B y los consecuentes cuatro ciclos estrales no mostraron diferencia estadística (p>0.05), se observó que en todos los grupos ocurrieron en lapsos cercanos al tratamiento, ya que en los dos experimentos un 83.8% y un 82.3% correspondieron a los 0-5 días del retiro del CIDR-B y a los dos siguientes ciclos estrales. Del estudio se concluye que el estradiol (1 ó 2 mg) indujo la presencia de un mayor número de animales en celo; sin embargo, esto no se tradujo en un mejor índice de ovulación y gestación, aunque habría que considerar otros factores que influyeron en los resultados como la nutrición y el amamantamiento. &nbsp

Illuminating the multidimensional contributions of small-scale fisheries.

Sustainable development aspires to "leave no one behind"1. Even so, limited attention has been paid to small-scale fisheries (SSF) and their importance in eradicating poverty, hunger and malnutrition. Through a collaborative and multidimensional data-driven approach, we have estimated that SSF provide at least 40% (37.3 million tonnes) of global fisheries catches and 2.3 billion people with, on average, 20% of their dietary intake across six key micronutrients essential for human health. Globally, the livelihood of 1 in every 12 people, nearly half of them women, depends at least partly on small-scale fishing, in total generating 44% (US$77.2 billion) of the economic value of all fisheries landed. Regionally, Asian SSF provide fish, support livelihoods and supply nutrition to the largest number of people. Relative to the total capture of the fisheries sector (comprising large-scale and small-scale fisheries), across all regions, African SSF supply the most catch and nutrition, and SSF in Oceania improve the most livelihoods. Maintaining and increasing these multidimensional SSF contributions to sustainable development requires targeted and effective actions, especially increasing the engagement of fisherfolk in shared management and governance. Without management and governance focused on the multidimensional contributions of SSF, the marginalization of millions of fishers and fishworkers will worsen

Cultura Organizacional

Culture is present in every area of our lives, since we grow up, we develop values, skills, beliefs, and attitudes derived from this. In an organization it is vital to adapt to its structure and to know why within this structure everything that involves the intellectual and human capital of the organization is involved, as well as its performance in it, therefore it is important to understand what organizational culture is, why is it important and why is it necessary for an organization?La cultura está presente en cada ámbito de nuestra vida, desde que crecemos desarrollamos valores, habilidades, creencias y actitudes derivadas de esta. En una organización es vital adaptarse a su estructura y conocer porqué dentro de esta se involucra todo lo que conlleva el capital intelectual y humano de la organización, así como su desempeño en la misma, por ello es importante entender ¿Qué es la cultura organizacional? ¿Por qué es importante? ¿Y por qué es necesaria para una organización

High-dimensional single-cell analysis of human natural killer cell heterogeneity

\ua9 The Author(s) 2024.Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their classification hinged on a limited array of surface protein markers. Here, we used single-cell RNA sequencing (scRNA-seq) and cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) to dissect the heterogeneity of NK cells. We identified three prominent NK cell subsets in healthy human blood: NK1, NK2 and NK3, further differentiated into six distinct subgroups. Our findings delineate the molecular characteristics, key transcription factors, biological functions, metabolic traits and cytokine responses of each subgroup. These data also suggest two separate ontogenetic origins for NK cells, leading to divergent transcriptional trajectories. Furthermore, we analyzed the distribution of NK cell subsets in the lung, tonsils and intraepithelial lymphocytes isolated from healthy individuals and in 22 tumor types. This standardized terminology aims at fostering clarity and consistency in future research, thereby improving cross-study comparisons

OME-Zarr: a cloud-optimized bioimaging file format with international community support

A growing community is constructing a next-generation file format (NGFF) for bioimaging to overcome problems of scalability and heterogeneity. Organized by the Open Microscopy Environment (OME), individuals and institutes across diverse modalities facing these problems have designed a format specification process (OME-NGFF) to address these needs. This paper brings together a wide range of those community members to describe the cloud-optimized format itself—OME-Zarr—along with tools and data resources available today to increase FAIR access and remove barriers in the scientific process. The current momentum offers an opportunity to unify a key component of the bioimaging domain—the file format that underlies so many personal, institutional, and global data management and analysis tasks

A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C

Caspase-6 is a cysteinyl protease implicated in neurodegenerative conditions including Alzheimer's and Huntington's disease making it an attractive target for therapeutic intervention. A greater understanding of the role of caspase-6 in disease has been hampered by a lack of suitable cellular assays capable of specifically detecting caspase-6 activity in an intact cell environment. This is mainly due to the use of commercially available peptide substrates and inhibitors which lack the required specificity to facilitate development of this type of assay. We report here a 384-well whole-cell chemiluminescent ELISA assay that monitors the proteolytic degradation of endogenously expressed lamin A/C during the early stages of caspase-dependent apoptosis. The specificity of lamin A/C proteolysis by caspase-6 was demonstrated against recombinant caspase family members and further confirmed in genetic deletion studies. In the assay, plasma membrane integrity remained intact as assessed by release of lactate dehydrogenase from the intracellular environment and the exclusion of cell impermeable peptide inhibitors, despite the induction of an apoptotic state. The method described here is a robust tool to support drug discovery efforts targeting caspase-6 and is the first reported to specifically monitor endogenous caspase-6 activity in a cellular context

Chemical Defense by the Native Winter Ant (Prenolepis imparis) against the Invasive Argentine Ant (Linepithema humile)

The invasive Argentine ant (Linepithema humile) is established worldwide and displaces native ant species. In northern California, however, the native winter ant (Prenolepis imparis) persists in invaded areas. We found that in aggressive interactions between the two species, P. imparis employs a potent defensive secretion. Field observations were conducted at P. imparis nest sites both in the presence and absence of L. humile. These observations suggested and laboratory assays confirmed that P. imparis workers are more likely to secrete when outnumbered by L. humile. Workers of P. imparis were also more likely to secrete near their nest entrances than when foraging on trees. One-on-one laboratory trials showed that the P. imparis secretion is highly lethal to L. humile, causing 79% mortality. The nonpolar fraction of the secretion was chemically analyzed with gas chromatography/mass spectrometry, and found to be composed of long-chain and cyclic hydrocarbons. Chemical analysis of dissected P. imparis workers showed that the nonpolar fraction is derived from the Dufour's gland. Based on these conclusions, we hypothesize that this chemical defense may help P. imparis to resist displacement by L. humile