КАЧЕСТВО ЖИЗНИ ЖЕНЩИН, ОПЕРИРОВАННЫХ ПО ПОВОДУ РАКА ПРЯМОЙ КИШКИ

Quality of life is the second most important clinical outcome criteria for cancer patients after survival. Quality of life shows the completeness of social rehabilitations of patients, who underwent radical treatment. In present study quality of life of 41 rectal cancer patients, who underwent abdominoperineal resection (n = 22) or anterior resection (n = 19) was assessed using SF-36 questionnaire. All patients without permanent colostomy had better postoperative quality of life. The phycho-emotional state of patients with permanent colostomy progres-sively decreases. The present study is important for developing an individualized rehabilitation programme for female rectal cancer patients.Качество жизни онкологических пациентов является вторым показателем эффективности лечения после продолжительности жизни. Показатели качества жизни демонстрируют, насколько полно пациенты, перенесшие радикальное лечение по поводу злокачественного новообразования, готовы к своей роли в обществе. В проведенном исследовании использована краткая форма адаптированной русскоязычной версии медицинского опросника SF-36 для оценки качества жизни 41 женщины с колоректальным раком (КРР), которым была выполнена брюшно-промежностная экстирпация (БПЭ) прямой кишки с наложением стомы (22 женщины) или передняя резекция прямой кишки (19 женщин). Качество жизни по результатам исследования было выше у пациенток без стомы на всех этапах после операции. У всех женщин, перенесших хирургическое вмешательство, в течение недели после операции показатели качества жизни снижаются, в большей степени после БПЭ прямой кишки. У больных со стомой через месяц после операции показатели ролевого функционирования, обусловленные физическим и эмоциональным состоянием, не восстанавливаются и продолжают прогрессивно снижаться. Проведенное исследование подготавливает информационную базу для разработки комплексной личностно-ориентированной программы реабилитации женщин с КРР

Middle East respiratory syndrome coronavirus specific antibodies in naturally exposed Israeli llamas, alpacas and camels

Thus far, no human MERS-CoV infections have been reported from Israel. Evidence for the circulation of MERS-CoV in dromedaries has been reported from almost all the countries of the Middle East, except Israel. Therefore, we aimed to analyze MERS-CoV infection in Israeli camelids, sampled between 2012 and 2017. A total of 411 camels, 102 alpacas and 19 llamas' sera were tested for the presence of antibodies to MERS-CoV. Our findings indicate a lower MERS-CoV seropositivity among Israeli dromedaries than in the surrounding countries, and for the first time naturally infected llamas were identified. In addition, nasal swabs of 661 camels, alpacas and lamas, obtained from January 2015 to December 2017, were tested for the presence of MERS-CoV RNA. All nasal swabs were negative, indicating no evidence for MERS-CoV active circulation in these camelids during that time period

The role of complement in ocular pathology

Functionally active complement system and complement regulatory proteins are present in the normal human and rodent eye. Complement activation and its regulation by ocular complement regulatory proteins contribute to the pathology of various ocular diseases including keratitis, uveitis and age-related macular degeneration. Furthermore, a strong relationship between age-related macular degeneration and polymorphism in the genes of certain complement components/complement regulatory proteins is now well established. Recombinant forms of the naturally occurring complement regulatory proteins have been exploited in the animal models for treatment of these ocular diseases. It is hoped that in the future recombinant complement regulatory proteins will be used as novel therapeutic agents in the clinic for the treatment of keratitis, uveitis, and age-related macular degeneration

EPHA2 Is Associated with Age-Related Cortical Cataract in Mice and Humans

Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract. Although a significant fraction of age-related cataract is heritable, the genetic basis remains to be elucidated. We report that homozygous deletion of Epha2 in two independent strains of mice developed progressive cortical cataract. Retroillumination revealed development of cortical vacuoles at one month of age; visible cataract appeared around three months, which progressed to mature cataract by six months. EPHA2 protein expression in the lens is spatially and temporally regulated. It is low in anterior epithelial cells, upregulated as the cells enter differentiation at the equator, strongly expressed in the cortical fiber cells, but absent in the nuclei. Deletion of Epha2 caused a significant increase in the expression of HSP25 (murine homologue of human HSP27) before the onset of cataract. The overexpressed HSP25 was in an underphosphorylated form, indicating excessive cellular stress and protein misfolding. The orthologous human EPHA2 gene on chromosome 1p36 was tested in three independent worldwide Caucasian populations for allelic association with cortical cataract. Common variants in EPHA2 were found that showed significant association with cortical cataract, and rs6678616 was the most significant in meta-analyses. In addition, we sequenced exons of EPHA2 in linked families and identified a new missense mutation, Arg721Gln, in the protein kinase domain that significantly alters EPHA2 functions in cellular and biochemical assays. Thus, converging evidence from humans and mice suggests that EPHA2 is important in maintaining lens clarity with age

An Adjustable Magnetic Prism Carrier for Strabismus Evaluation

"The analysis and quantitation of strabismus can be challenging to examiner and patient, especially when the deviation is large or complex. This can be due to the difficulty of holding multiple prisms in proper alignment and also the difficulty of conducting trials of prisms during real life use for prolonged periods. Most trial frame sets have limits on prism size. We have designed a continuously adjustable, head mounted magnetic prism carrier (MPC) which allows for placement of any strength prism in proper alignment to facilitate strabismus evaluation.

A Novel Hand Held Instrument for Quantitating Diplopic Visual Fields

Diplopia assessment is critical in evaluating conditions including: thyroid associated orbitopathy (TAO), orbital trauma, and idiopathic orbital inflammation (IOI) among others. Currently diplopia is assessed using: qualtitative clinical assessment, prism quantitatition of deviation, and techniques like Goldmann perimeters which though accurate, require specialized unavailable instruments. We developed a simple hand-held instrument (diplopometer) that allows reproducible quantitative assessment of the diplopic field. It has the resolution and reproducibility of the most sophisticated instruments