Computing Matveev's complexity via crystallization theory: the boundary case

The notion of Gem-Matveev complexity has been introduced within crystallization theory, as a combinatorial method to estimate Matveev's complexity of closed 3-manifolds; it yielded upper bounds for interesting classes of such manifolds. In this paper we extend the definition to the case of non-empty boundary and prove that for each compact irreducible and boundary-irreducible 3-manifold it coincides with the modified Heegaard complexity introduced by Cattabriga, Mulazzani and Vesnin. Moreover, via Gem-Matveev complexity, we obtain an estimation of Matveev's complexity for all Seifert 3-manifolds with base $\mathbb D^2$ and two exceptional fibers and, therefore, for all torus knot complements.Comment: 27 pages, 14 figure

Compact 3-manifolds via 4-colored graphs

We introduce a representation of compact 3-manifolds without spherical boundary components via (regular) 4-colored graphs, which turns out to be very convenient for computer aided study and tabulation. Our construction is a direct generalization of the one given in the eighties by S. Lins for closed 3-manifolds, which is in turn dual to the earlier construction introduced by Pezzana's school in Modena. In this context we establish some results concerning fundamental groups, connected sums, moves between graphs representing the same manifold, Heegaard genus and complexity, as well as an enumeration and classification of compact 3-manifolds representable by graphs with few vertices ($\le 6$ in the non-orientable case and $\le 8$ in the orientable one).Comment: 25 pages, 11 figures; changes suggested by referee: references added, figure 2 modified, results about classification of the manifolds in Proposition 17 announced at the end of section 9. Accepted for publication in RACSAM. The final publication is available at Springer (see DOI

Gratitude among advanced cancer patients and their caregivers: The role of early palliative care

Objective: A cancer diagnosis represents a unique trauma, given its life-threatening, multidimensional, and uncertain nature. Gratitude is a construct representing the emotional state that arises when individuals recognize that a benefit has been received as a result of someone else’s action or a spiritual entity’s intervention. Based on the positive psychological wellbeing, gratitude has been associated with improved health outcomes even in the disease setting. Thus, the models of care that foster gratitude should be adopted in the clinical context. This study aims to explore whether and how gratitude may originate in patients with advanced cancer and their caregivers undergoing early palliative care (EPC). Methods: We analyzed 251 reports from 133 patients and 118 caregivers describing their clinical experience in two EPC units. The sources of gratitude were identified and ranked based on their frequencies. Words expressing gratitude and words referring to communication and spirituality were collected by means of the Linguistic Inquiry and Word Count software and correlated. Results: In total, 123 (92.5%) of 133 patients’ and 97 (82.2%) of 118 caregivers’ reports, respectively, included explicit or implicit expressions of gratitude. Gratitude was associated specifically with successful physical symptom management, emotional support, improved attitude toward death, better information, humanity, and the familiar environment. The use of words of gratitude in patients’ reports was positively correlated with the use of words referring to communication (r =.215, p =.026) and spirituality (r =.612, p <.001). Conclusion: Our results suggest that interventions within the EPC model based on doctor–patient–caregiver communication may allow patients and caregivers to experience a feeling of gratitude, and this may represent a resource to be exploited to improve their physical and psychosocial wellbeing

Early Palliative Care in Acute Myeloid Leukemia

Background: Several novel targeted therapies seem to improve the outcome of acute myeloid leukemia (AML) patients. Nonetheless, the 5-year survival rate remains below 40%, and the trajectory of the disease remains physically and emotionally challenging, with little time to make relevant decisions. For patients with advanced solid tumors, the integration of early palliative care (EPC) with standard oncologic care a few weeks after diagnosis has demonstrated several benefits. However, this model is underutilized in patients with hematologic malignancies. Methods: In this article, we analyze the palliative care (PC) needs of AML patients, examine the operational aspects of an integrated model, and review the evidence in favor of EPC integration in the AML course. Results: AML patients have a high burden of physical and psychological symptoms and high use of avoidant coping strategies. Emerging studies, including a phase III randomized controlled trial, have reported that EPC is feasible for inpatients and outpatients, improves quality of life (QoL), promotes adaptive coping, reduces psychological symptoms, and enhances the quality of end-of-life care. Conclusions: EPC should become the new standard of care for AML patients. However, this raises issues about the urgent development of adequate programs of education to increase timely access to PC

Computing Matveev's complexity via crystallization theory: the orientable case

By means of a slight modification of the notion of GM-complexity introduced in [Casali, M.R., Topol. Its Appl., 144: 201-209, 2004], the present paper performs a graph-theoretical approach to the computation of (Matveev's) complexity for closed orientable 3-manifolds. In particular, the existing crystallization catalogue C-28 available in [Lins, S., Knots and Everything 5, World Scientific, Singapore, 1995] is used to obtain upper bounds for the complexity of closed orientable 3-manifolds triangulated by at most 28 tetrahedra. The experimental results actually coincide with the exact values of complexity, for all but three elements. Moreover, in the case of at most 26 tetrahedra, the exact value of the complexity is shown to be always directly computable via crystallization theory

The impact of socioeconomic and phenotypic traits on self-perception of ethnicity in Latin America

Self-perception of ethnicity is a complex social trait shaped by both, biological and non-biological factors. We developed a comprehensive analysis of ethnic self-perception (ESP) on a large sample of Latin American mestizos from five countries, differing in age, socio-economic and education context, external phenotypic attributes and genetic background. We measured the correlation of ESP against genomic ancestry, and the influence of physical appearance, socio-economic context, and education on the distortion observed between both. Here we show that genomic ancestry is correlated to aspects of physical appearance, which in turn affect the individual ethnic self-perceived ancestry. Also, we observe that, besides the significant correlation among genomic ancestry and ESP, specific physical or socio-economic attributes have a strong impact on self-perception. In addition, the distortion among ESP and genomic ancestry differs across age ranks/countries, probably suggesting the underlying effect of past public policies regarding identity. Our results indicate that individuals’ own ideas about its origins should be taken with caution, especially in aspects of modern life, including access to work, social policies, and public health key decisions such as drug administration, therapy design, and clinical trials, among others

ELABORAÇÃO DE CERVEJA ARTESANAL COM SUCO E AROMA NATURAL DE MAÇÃ

A cerveja é a bebida alcoólica mais consumida no mundo. Estando bem relacionada com festividades e comemorações, essa bebida contém uma variedade de compostos bioativos, vitaminas e minerais, capazes de promover benefícios, quando a sua ingestão é feita de maneira moderada.O mercado está a cada dia buscando produtos diferenciados e atéexclusivos. Surge assim, o campo das cervejas artesanais. Observa-se um aumento considerável pela procura e desenvolvimento de novos produtos biotecnológicos na área de alimentos e, no caso da cerveja, a presença de produtos diferentes dos que seguem a Lei da Pureza Alemã. O objetivo foi desenvolver uma formulação de cerveja artesanal do estilo witbier com aroma e suco natural de maçã. As witbier são geralmente vendidas comoacompanhamento para sobremesas. Seu aroma e sabor sãoagradavelmente cítricos e secos. Foram realizadas análises físico-químicas (pH, teor alcoólico, acidez total, acidez volátil, acidez fixa, cinzas, extrato real, extrato primitivo e açúcares totais) e microbiológias (contagem total padrão, contagem de fungos e leveduras, contagem de enterobactériase contagem de Staphilococcus aureus), estando de acordo com a legislação.Foram realizados, também, testes de aceitação sensorial (aparência global, sabor, cor, aroma, amargor, carbonatação, espuma, doçura), apresentando resultados satisfatórios, sendo a formulação com 0,8% de suco concentrado de maçã e 0,5 % de aroma natural de maçã a de melhor aceitação

Early palliative care versus usual haematological care in multiple myeloma: retrospective cohort study

Objectives Although early palliative care (EPC) is beneficial in acute myeloid leukaemia, little is known about EPC value in multiple myeloma (MM). We compared quality indicators for palliative and end of life (EOL) care in patients with MM receiving EPC with those of patients who received usual haematological care (UHC).Methods This observational, retrospective study was based on 290 consecutive patients with MM. The following indicators were abstracted: providing psychological support, assessing/managing pain, discussing goals of care, promoting advance care plan, accessing home care services; no anti MM treatment within 14 and 30 days and hospice length of stay >7 days before death; no cardiopulmonary resuscitation, no intubation, <2 hospitalisations and emergency department visits within 30 days before death. Comparisons were performed using unadjusted and confounder adjusted regression models.Results 55 patients received EPC and 231 UHC. Compared with UHC patients, EPC patients had a significantly higher number of quality indicators of care (mean 2.62 +/- 1.25 vs 1.12 +/- 0.95; p<0.0001)); a significant reduction of pain intensity over time (p<0.01) and a trend towards reduced aggressiveness at EOL, with the same survival (5.3 vs 5.46 years; p=0.74)).Conclusions Our data support the value of integrating EPC into MM routine practice and lay the groundwork for future prospective comparative studies