Future directions for the management of pain in osteoarthritis.

Osteoarthritis (OA) is the predominant form of arthritis worldwide, resulting in a high degree of functional impairment and reduced quality of life owing to chronic pain. To date, there are no treatments that are known to modify disease progression of OA in the long term. Current treatments are largely based on the modulation of pain, including NSAIDs, opiates and, more recently, centrally acting pharmacotherapies to avert pain. This review will focus on the rationale for new avenues in pain modulation, including inhibition with anti-NGF antibodies and centrally acting analgesics. The authors also consider the potential for structure modification in cartilage/bone using growth factors and stem cell therapies. The possible mismatch between structural change and pain perception will also be discussed, introducing recent techniques that may assist in improved patient phenotyping of pain subsets in OA. Such developments could help further stratify subgroups and treatments for people with OA in future

Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection.

Innate immune cells quickly infiltrate the site of pathogen entry and not only stave off infection but also initiate antigen presentation and promote adaptive immunity. The recruitment of innate leukocytes has been well studied in the context of extracellular bacterial and fungal infection but less during viral infections. We have recently shown that the understudied cytokine Interleukin (IL)-17D can mediate neutrophil, natural killer (NK) cell and monocyte infiltration in sterile inflammation and cancer. Herein, we show that early immune cell accumulation at the peritoneal site of infection by mouse cytomegalovirus (MCMV) is mediated by IL-17D. Mice deficient in IL-17D or the transcription factor Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), an inducer of IL-17D, featured an early decreased number of innate immune cells at the point of viral entry and were more susceptible to MCMV infection. Interestingly, we were able to artificially induce innate leukocyte infiltration by applying the Nrf2 activator tert-butylhydroquinone (tBHQ), which rendered mice less susceptible to MCMV infection. Our results implicate the Nrf2/IL-17D axis as a sensor of viral infection and suggest therapeutic benefit in boosting this pathway to promote innate antiviral responses

Efectul sel-plex asupra afecţiunilor gastrointestinale şi a stresului oxidativ la puii broiler

The study carried out on a lot of 80 broiler chickens COBB-500, divided into a control group and an experimental group assessed the influence of Sel-Plex product (organic selenium) on the bioproductive indices and blood parameters. The chicks from the experimental group were administered, in addition to their basic ration, the Sel-Plex product in dose of 0,4 mg Se/1kg of feed, from one to 49 days of age. The results of investigations of clinical indices (general state, plumage, behavior, feed intake, daily weight gain, morbidity, and lethality) revealed the positive effect of supplementing daily rations with organic selenium on the growth and development of chickens. The lethality rate was lower in the experimental group (0 %) in comparison with the control (5 %). The body weight was 4,63 % higher compared to chickens of the control group. The dynamics of paraclinical indices (erythron, biochemical parameters, malondialdehyde content, activity of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase in serum) show that the Sel-Plex product has beneficial effects on erythropoiesis, metabolic and antioxidant status

Future therapeutic targets in rheumatoid arthritis?

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint inflammation. Without adequate treatment, patients with RA will develop joint deformity and progressive functional impairment. With the implementation of treat-to-target strategies and availability of biologic therapies, the outcomes for patients with RA have significantly improved. However, the unmet need in the treatment of RA remains high as some patients do not respond sufficiently to the currently available agents, remission is not always achieved and refractory disease is not uncommon. With better understanding of the pathophysiology of RA, new therapeutic approaches are emerging. Apart from more selective Janus kinase inhibition, there is a great interest in the granulocyte macrophage-colony stimulating factor pathway, Bruton's tyrosine kinase pathway, phosphoinositide-3-kinase pathway, neural stimulation and dendritic cell-based therapeutics. In this review, we will discuss the therapeutic potential of these novel approaches

Influienţa prebioticului ANCO®FIT – Poultry asupra performanței de creștere și a indicilor sangvini la puii de carne COB 500

The study on 2 groups of 25 chickens, divided into a control group and an experimental group, assessed the influence of ANCO®FIT – Poultry containing organic component, mineral component and. ANCO®FIT – Poultry was administered in food at a concentration of 1 g/kg of food during the age (1-43 days). Findings: The body weight was 401 g higher compared to chickens in the control group. Some hematological and biochemical indices tended to increase in broiler chickens in the experimental group

Influenţa acidifianţilor asupra indicilor bioproductivi şi biochimici la găinele de rasa argintie de Adler

The present study was carried out to determine the effect of dietary organic acid mixture supplementation (product Pro Git) on performance (body weight changes, egg production) and concentration of some blood serum parameters in laying hens ,,Silver Adler”. A total 41 week old 2800 laying hens which were allotted into 2 groups, each containing 1400 hens. The hens were fed with diets (17,5% CP% and 2720 Kcal). Supplemented with 0% (control group 1), and 0,3 %(group 2) of organic acid mixture – Pro Git (formic acid, propionic and lactic acids). The dietary organic acids modify live body weight in groups 2 when compared with control one. Organic acids supplementation significantly increased egg production by about 2,7% compared with the untreated group. The data revealed that linear increase of serum calcium and concentration of total serum protein. From the obtained data can be concluding that organic acid supplementation at level 0,3 % of laying hens diet improve live body weight, improve persistence of lay and from economical point of view we can concluded that organic acid addition (0,3 %) amazing increase the economical efficiency of layer production

Impactul pro/prebioticului Biomin C-EX asupra unor parametri ai stării funcţionale a ficatului la tineretul pui broiler

The researches were carried out on two groups of chicken COB 500 - control and experimental. The purpose of the study was finding of some possibilities for improving the productive performances and prevention of gastro-enteropathies in chickens, by administration in drinking water of the pro/prebiotic Biomin C-EX. It has been demonstrated that the studied product no side effects, induced an increase of biochemical parameters. Have positive effects on the activity of the liver. The viability of broilers constituted 97.5% and 95% in the experimental and control groups, respectively