Testicular mixed germ cell tumor with polyembryoma component in brothers

PubMedID: 15803215We report the case of a 17-year-old male with a testicular tumor and high serum levels of ?-fetoprotein. The patient was treated with surgery followed by combination chemotherapy with bleomycin, etoposide, and cisplatin. Histologic examination showed features of a mixed germ cell tumor composed of mature teratoma, immature teratoma, embryonal carcinoma, yolk sac tumor, and polyembryoma. He is currently well, and his serum levels of ?-fetoprotein have been normal more than 5 months after treatment. His brother, aged 17 years at the time, had a similar tumor removed from the right testicle 5 years previously. © 2004 Society for Pediatric Pathology

Histologic grading for psoriasis and psoriasiform tissue reactions

Among the dermatoses which show psoriasiform tissue reactions, psoriasis has characteristic histological features where others mimic these features. Atypical lesions of psoriasis or the ones under therapy can not be easily differentiated from other forms of psoriasiform dermatitis. The role of histological parameters in the differential diagnosis of these entities were investigated in our study. Two groups were constituted, one with 20 subjects with the histological diagnosis of psoriasis and the other with 15 subjects with the histological diagnosis of psoriasiform dermatitis. The extents of acanthosis, basal membrane disruption, and thinning of suprapapillary epidermal plates in psoriasis group were found to be significantly greater than that in psoriasiform dermatitis group. As a conclusion, grading the histopathological parameters may indicate some clues which may help in the histological diagnosis of atypical forms of psoriasis