Occupational Mortality, Age at Marriage and Marital Fertility Early Twentieth Century England and Wales

What factors determine fertility and to what extent do we really understand the decision processes that underpinned when to marry, when to start having children and how many children to have in the historical past? In many ways, the posing of such questions may seem surprising given the now copious literature on the subject.1 In this paper we use new datasets built from previously under-exploited primary source materials and improved econometric modelling to build on previous work and thereby improve on our understanding of the determinants of the demand for children in early twentieth century England and Wales

Experimental assembly of structures in EVA: Hardware morphology and development issues

A large body of data was obtained by MIT during neutral boyancy testing at Marshall Space Flight Center from 1980 to the present. These efforts, and the most significant results are summarized. The Experimental Assembly of Structure in EVA (EASE) flight experiment was undertaken to validate these results and flown on the STS 61-B in November 1985. The EASE experiment hardware is discussed and how the experiment goals dictate its size, shape, and operational characteristics, are illustrated

Cadmium sulfide in a Mesoproterozoic terrestrial environment

Peer reviewedPostprin

Surface mineral crusts: A priority target in search for life on Mars

Mineral crusts are strong candidates in the search for evidence of life during planetary exploration, and should be an important target for examination in impact craters. Crusts in the Haughton crater readily yield a biological signature

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score

Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. MR is being widely used in epidemiology and other related areas of population science. In this paper, we study statistical inference in the increasingly popular two-sample summary-data MR design. We show a linear model for the observed associations approximately holds in a wide variety of settings when all the genetic variants satisfy the exclusion restriction assumption, or in genetic terms, when there is no pleiotropy. In this scenario, we derive a maximum profile likelihood estimator with provable consistency and asymptotic normality. However, through analyzing real datasets, we find strong evidence of both systematic and idiosyncratic pleiotropy in MR, echoing the omnigenic model of complex traits that is recently proposed in genetics. We model the systematic pleiotropy by a random effects model, where no genetic variant satisfies the exclusion restriction condition exactly. In this case we propose a consistent and asymptotically normal estimator by adjusting the profile score. We then tackle the idiosyncratic pleiotropy by robustifying the adjusted profile score. We demonstrate the robustness and efficiency of the proposed methods using several simulated and real datasets.Comment: 59 pages, 5 figures, 6 table

Monitoring the Thermal Power of Nuclear Reactors with a Prototype Cubic Meter Antineutrino Detector

In this paper, we estimate how quickly and how precisely a reactor's operational status and thermal power can be monitored over hour to month time scales, using the antineutrino rate as measured by a cubic meter scale detector. Our results are obtained from a detector we have deployed and operated at 25 meter standoff from a reactor core. This prototype can detect a prompt reactor shutdown within five hours, and monitor relative thermal power to three percent within seven days. Monitoring of short-term power changes in this way may be useful in the context of International Atomic Energy Agency's (IAEA) Reactor Safeguards Regime, or other cooperative monitoring regimes.Comment: 10 pages, 9 figure