Damping of vertical coronal loop kink oscillations through wave tunneling

The decay rate of vertical kink waves in a curved flux tube is modeled numerically. The full MHD equations are solved for a curved equilibrium flux tube in an arcade geometry and the decay of ψ, the integral over the flux tube of the modulus of the velocity perpendicular to the local magnetic field, is measured. These simulations are 2D and are thus restricted to kink oscillations in the loop plane. The decay rate is found to increase with increasing wavelength, increasing β and decreasing density contrast ratio. The wave tunneling effect is shown to be a possible mechanism for the high decay rate of the recent observed kink oscillation reported by Wang & Solanki (2004)

Leakage of waves from coronal loops by wave tunneling

To better understand the decay of vertically polarised fast kink modes of coronal loops by the mechanism of wave tunneling, simulations are performed of fast kink modes in straight flux slabs which have Alfvén speed profiles which include a tunneling region. The decay rates are found to be determined by the mode number of the trapped mode and the thickness of the tunneling region. Two analytical models are suggested to explain the observed decay. The first is a extension of the work of Roberts (1981, Sol. Phys., 69, 39) to include a finite thickness tunneling region, and the second is a simpler model which yields an analytical solution for the relationship between decay rate, period and the thickness of the tunneling region. The decay rates for these straight slabs are found to be slower than in observations and those found in a previous paper on the subject by Brady & Arber (2005, A&A, 438, 733) using curved flux slabs. It is found that the difference between the straight slabs used here and the curved slabs used in Brady & Arber (2005, A&A, 438, 733) can be represented as a geometric correction to the decay rate

Consommation des jeunes et jeunes adultes en fin de semaine : Evolution entre 2011, 2013 et 2015

Parmi les 691 jeunes de 15 à 29 ans qui ont participé au module jeune en 2015, 629 sont sortis au cours des 30 jours précédant la passation de l’enquête. Les réponses données par ces derniers permettent de compléter les résultats déjà obtenus précédemment concernant les consommations des jeunes lors de leur dernière sortie de fin de semaine. De manière générale, il n’existe pas de tendance nette chez les jeunes vers une hausse ou une diminution de la consommation de substances entre 2011 et 2015. L’alcool reste la substance la plus consommée par les jeune

Caring for a loved one with a malignant fungating wound

Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)Purpose: Caring for a loved one with a malignant fungating wound is very challenging and causes extreme physical and psychological distress. The aim of this study was to explore the experiences of carers who care for a loved one with a fungating breast wound. Method: To explore the lived experiences of carers, a methodological framework using Heideggerian hermeneutic phenomenology and semi-structured interviews was used. Seven carers were interviewed from January until November 2009. Results: Having to deal with a situation of a loved one with a visible cancer was hard for all the carers. The visibility of the cancer was one of the most shocking aspects to deal with from the perspective of the patient and the carer. The presence of the visible wound and a cancer at an advanced stage contributed to a change in the relationship and extreme suffering for both the patient and the carer. Despite many problems such as wound odour and copious discharge from the wound, which was difficult to control, carers did their best to help their loved one with the wound. Gradually, the wound became the centre of the patient and carer’s life, and a great deal of time was spent trying to control the wound symptoms. All carers managed the wound on their own without help and advice from health care practitioners. For all of them, it was a major burden and they felt isolated. Conclusion: This study contributes to an understanding that the care of women and their carers needs strategies that are integrated in palliative wound care that takes a holistic and empathic approach that responds to patients’ and carers’ psychosocial and emotional needs and a practical need for information to help carers assist in managing the wound-related symptoms

Managing sleep and wakefulness in a 24 hour world

This article contributes to literature on the sociology of sleep by exploring the sleeping practices and subjective sleep experiences of two social groups: shift workers and students. It draws on data, collected in the UK from 25 semi-structured interviews, to discuss the complex ways in which working patterns and social activities impact upon experiences and expectations of sleep in our wired awake world. The data show that, typically, sleep is valued and considered to be important for health, general wellbeing, appearance and physical and cognitive functioning. However, sleep time is often cut back on in favour of work demands and social activities. While shift workers described their efforts to fit in an adequate amount of sleep per 24-hour period, for students, the adoption of a flexible sleep routine was thought to be favourable for maintaining a work–social life balance. Collectively, respondents reported using a wide range of strategies, techniques, technologies and practices to encourage, overcome or delay sleep(iness) and boost, promote or enhance wakefulness/alertness at socially desirable times. The analysis demonstrates how social context impacts not only on how we come to think about sleep and understand it, but also how we manage or self-regulate our sleeping patterns

Consommation des jeunes et des jeunes adultes les fins de semaines

[Sommaire] Résumé. - 1 Introduction (Brève description du Monitorage suisse des addictions. - Module). - 2 Questions de recherche et Méthode pour l'enquête téléphonique: module 4 (module spécifique dans l'enquête CoRolAR) (Questions de recherche. - Méthode. - Limites. - Présentation du questionnaire. - Traitements statistiques). - 3 Données sociodémographiques. - 4 Données descriptives par catégorie d'âge et de sexe (Aperçu des consommations de substances psychoactives. - Multi-consommation lors de la dernière sortie. - Détail des consommations de substances psychoactives. - Prise de risques. - Finances. - Lieu de sortie). - 5 Données descriptives par région linguistique (Consommation. - Prise de risque). - 6 Consommations excessives (Les consommateurs à risque lors de la dernière sortie de fin de semaine. - Comparaisons des données sociodémographiques dans les deux populations d'intérêt. - Comparaison des consommations de substances psychoactives dans les deux populations d'intérêt. - Prise de risques. - Finances). - 7 Les jeunes qui ne sortent pas (Comparaisons des données sociodémographiques. - des consommations de substances psychoactives dans les deux échantillons). - 8 Conclusion. - 9 Référence

Evaluation du dispositif d'urgences sociales EMUS

Le concept EMUS (équipe mobile d'urgences sociales) trouve son origine dans la réunion consacrée à l'urgence sociale qui s'est tenue en fin d'année 2009 et dans le rapport sur la création de l'équipe mobile d'urgence établi en été 2010 à la suite de cette réunion. Le Département de la santé et de l'action sociale (DSAS) a mandaté l'IUMSP pour effectuer une évaluation accompagnante du projet dans sa phase pilote pour: Accompagner le projet par des bilans intermédiaires dans le but d'effectuer des ajustements du projet ; Mesurer l'impact du projet ; Évaluer le dispositif en place ; Évaluer le fonctionnement du dispositif ; Évaluer ses interventions. Les résultats de cette évaluation sont présentés dans le présent rapport. Des résultats intermédiaires (quantitatifs et qualitatifs) ont également été présentés au comité de pilotage de l'évaluation sous forme orale (présentations PowerPoint suivies d'une discussion), et cela à deux reprises (septembre 2012 et juin 2013). Une synthèse de ces résultats intermédiaires peut être consultée à l'annexe 8.

Simulations of Alfvén and Kink wave driving of the solar chromosphere : efficient heating and spicule launching

Two of the central problems in our understanding of the solar chromosphere are how the upper chromosphere is heated and what drives spicules. Estimates of the required chromospheric heating, based on radiative and conductive losses, suggest a rate of ~0.1 erg cm−3 s−1 in the lower chromosphere and drops to ~10−3 erg cm−3 s−1 in the upper chromosphere. The chromosphere is also permeated by spicules, higher density plasma from the lower atmosphere propelled upwards at speeds of ~10–20 km s−1, for so-called Type I spicules, which reach heights of ~3000–5000 km above the photosphere. A clearer understanding of chromospheric dynamics, its heating, and the formation of spicules is thus of central importance to solar atmospheric science. For over 30 years it has been proposed that photospheric driving of MHD waves may be responsible for both heating and spicule formation. This paper presents results from a high-resolution MHD treatment of photospheric driven Alfvén and kink waves propagating upwards into an expanding flux tube embedded in a model chromospheric atmosphere. We show that the ponderomotive coupling from Alfvén and kink waves into slow modes generates shocks, which both heat the upper chromosphere and drive spicules. These simulations show that wave driving of the solar chromosphere can give a local heating rate that matches observations and drive spicules consistent with Type I observations all within a single coherent model

Using human induced pluripotent stem cells to model cerebellar disease: Hope and hype

The cerebellum forms a highly ordered and indispensible component of motor function within the adult neuraxis, consisting of several distinct cellular subtypes. Cerebellar disease, through a variety of genetic and acquired causes, results in the loss of function of defined subclasses of neurons, and remains a significant and untreatable health care burden. The scarcity of therapies in this arena can partially be explained by unresolved disease mechanisms due to inaccessibility of human cerebellar neurons in a relevant experimental context where initiating disease mechanisms could be functionally elucidated, or drug screens conducted. In this review we discuss the potential promise of human induced pluripotent stem cells (hiPSCs) for regenerative neurology, with a particular emphasis on in vitro modelling of cerebellar degeneration. We discuss progress made thus far using hiPSC-based models of neurodegeneration, noting the relatively slower pace of discovery made in modelling cerebellar dysfunction. We conclude by speculating how strategies attempting cerebellar differentiation from hiPSCs can be refined to allow the generation of accurate disease models. This in turn will permit a greater understanding of cerebellar pathophysiology to inform mechanistically rationalised therapies, which are desperately needed in this field

Stem cell models of Alzheimer's disease: progress and challenges.

A major challenge to our understanding of the molecular mechanisms of Alzheimer's disease (AD) has been the lack of physiologically relevant in vitro models which capture the precise patient genome, in the cell type of interest, with physiological expression levels of the gene(s) of interest. Induced pluripotent stem cell (iPSC) technology, together with advances in 2D and 3D neuronal differentiation, offers a unique opportunity to overcome this challenge and generate a limitless supply of human neurons for in vitro studies. iPSC-neuron models have been widely employed to model AD and we discuss in this review the progress that has been made to date using patient-derived neurons to recapitulate key aspects of AD pathology and how these models have contributed to a deeper understanding of AD molecular mechanisms, as well as addressing the key challenges posed by using this technology and what progress is being made to overcome these. Finally, we highlight future directions for the use of iPSC-neurons in AD research and highlight the potential value of this technology to neurodegenerative research in the coming years