Evaluation of the burden of HPV-related hospitalizations as a useful tool to increase awareness: 2007–2017 data from the sicilian hospital discharge records

In light of the implementation of human papillomavirus (HPV) prevention strategies, epidemiological studies in different geographical areas are required in order to assess the impact of HPV-related diseases. The purpose of the present study was to describe the burden of HPV-related hospitalizations in Sicily. A retrospective observational study estimated 43,531 hospitalizations attributable to HPV from 2007 to 2017. During the observed period, there was a decrease for all HPV-related conditions with a higher reduction, among neoplasms, for cervical cancer (annual percent change (APC) = −9.9%, p < 0.001). The median age for cervical cancer was 45 years old, with an increasing value from 43 to 47 years (p < 0.001). The age classes with greater decreases in hospital admissions for invasive cancers were women aged 35 years or more (APC range from −5.5 to −9.86) and 25–34 years old (APC = −11.87, p < 0.001) for women with cervical carcinoma in situ. After ten years for vaccine introduction and sixteen years for cervical cancer screening availability, a relatively large decrease in hospital admissions for cervical cancer and other HPV-related diseases in Sicily was observed. Some clinical characteristics of hospitalization, such as increasing age, are suggestive clues for the impact of preventive strategies, but further research is needed to confirm this relationship

Analysis of web visit histories, part I: Distance-based visualization of sequence rules

This paper constitutes Part I of the contribution to the analysis of web visit histories through a new methodological framework. Firstly, web usage and web structure mining are considered as an unique mining process to detect the latent structure of the web navigation across the web sections of a single portal. We extend association rules theory to web data defining new concepts of web (patterns) association and preference matrices, as well as of (indirect and direct) sequence rules. We identify the most significant rules, according to a multiple testing procedure. In the literature, web usage patterns can be visualized in no-distance-based graphs describing the navigation behavior across web pages with sequential arrows. In the following, we introduce a geometrical visualization of sequence rules at any click of the web navigation. In particular, we provide two distance-based visualization methods for the static analysis of all data tout court and the dynamic analysis to discover the most significant web paths click by click. A real world case study is considered throughout the methodological description

How intelligent is a cephalopod? Lessons from comparative cognition.

The soft-bodied cephalopods including octopus, cuttlefish, and squid are broadly considered to be the most cognitively advanced group of invertebrates. Previous research has demonstrated that these large-brained molluscs possess a suite of cognitive attributes that are comparable to those found in some vertebrates, including highly developed perception, learning, and memory abilities. Cephalopods are also renowned for performing sophisticated feats of flexible behaviour, which have led to claims of complex cognition such as causal reasoning, future planning, and mental attribution. Hypotheses to explain why complex cognition might have emerged in cephalopods suggest that a combination of predation, foraging, and competitive pressures are likely to have driven cognitive complexity in this group of animals. Currently, it is difficult to gauge the extent to which cephalopod behaviours are underpinned by complex cognition because many of the recent claims are largely based on anecdotal evidence. In this review, we provide a general overview of cephalopod cognition with a particular focus on the cognitive attributes that are thought to be prerequisites for more complex cognitive abilities. We then discuss different types of behavioural flexibility exhibited by cephalopods and, using examples from other taxa, highlight that behavioural flexibility could be explained by putatively simpler mechanisms. Consequently, behavioural flexibility should not be used as evidence of complex cognition. Fortunately, the field of comparative cognition centres on designing methods to pinpoint the underlying mechanisms that drive behaviours. To illustrate the utility of the methods developed in comparative cognition research, we provide a series of experimental designs aimed at distinguishing between complex cognition and simpler alternative explanations. Finally, we discuss the advantages of using cephalopods to develop a more comprehensive reconstruction of cognitive evolution.A.K.S. was supported by an Endeavour Research Fellowship funded by the Australian Government and was also supported by a Newton International Fellowship funded by the Royal Society. P.A. received support from the Cambridge Philosophical Society (Research Studentship Ref. 123 S52/002/19). A European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC Grant Agreement No. 3399933 was awarded to N.S.C., which supported both M.B and N.S.C

The composite dataset of the present-day Infralittoral Prograding Wedges (IPWs) in the inner continental shelf of the Campania region (Central-Eastern Tyrrhenian Sea)

This article reports on the dataset gathered following the census of 83 present-day Infralittoral Prograding Wedges (IPWs), surveyed on the inner continental shelf of the Central-Eastern Tyrrhenian Sea. The purpose of the census was to explore their bathymetric range and assess the observational laws governing this variability. The ensued dataset (Campania Region IPW Dataset, CRID) includes geographic, topographic and morpho-bathymetric indices, descriptive of each IPW and more, the exposure of each IPW to wave forcing (Geographical fetch, Effective fetch and extreme significant wave height, HS). In this work, histograms contribute to describe all the variables and highlight the dominant features of each IPW. Location maps univocally links the geographic position of each IPW to the appropriate attribute record in the dataset. Further, thematic maps illustrate eight wave fields obtained by offshore-to-nearshore transformation by as many sea states scenarios with 200-year return period. Such wave fields are used as sources for significant wave height representing wave conditions over each IPW. This dataset could be implemented with new measures at a broader scale, by following analogue procedures for measurements, to enlarge the observational scale on IPWs and improve the numerical models which might eventually derive by the analysis of this dataset

The Subsurface Geology and Landscape Evolution of the Volturno Coastal Plain, Italy: Interplay between Tectonics and Sea-Level Changes during the Quaternary

The Volturno alluvial-coastal plain is a relevant feature of the Tyrrhenian side of Southern Italy. Its plan-view squared shape is due to Pliocene-Quaternary block-faulting of the western flank of the south-Apennines chain. On the basis of the stratigraphic analysis of almost 700 borehole logs and new geomorphological survey, an accurate paleoenvironmental reconstruction before and after the Campania Ignimbrite (CI; about 40 ky) eruption is here presented. Tectonics and eustatic forcing have been both taken into account to completely picture the evolution of the coastal plain during Late Quaternary times. The upper Pleistocene-Holocene infill of the Volturno plain has been here re-organized in a new stratigraphic framework, which includes seven depositional units. Structural analysis showed that two sets of faults displaced the CI, so accounting for recent tectonic activity. Yet Late Quaternary tectonics is rather mild, as evidenced by the decametric vertical separations operated by those faults. The average slip rate, which would represent the tectonic subsidence rate of the plain, is about 0.5 mm/year. A grid of cross sections shows the stratigraphic architecture which resulted from interactions among eustatic changes, tectonics and sedimentary input variations. On the basis of boreholes analysis, the trend of the CI roof was reconstructed. An asymmetrical shape of its ancient morphology - with a steeper slope toward the north-west border - and the lack of coincidence between the present course of the Volturno River and the main buried bedrock incision, are significant achievements of this study. Finally, the morpho-evolutionary path of the Volturno plain has been discussed

Estimating the burden of hospitalization for pneumococcal pneumonia in a general population aged 50 years or older and implications for vaccination strategies

Streptococcus pneumoniae is a major cause of human infectious diseases worldwide. Despite this documented evidence, data on pneumococcal disease rates among general populations are scant because of the frequent lack of cultural identification. In this study we propose a model for estimating the burden of pneumococcal pneumonia on hospitalizations. The study was performed by analyzing administrative and clinical data of patients aged 50 years or older, resident in Sicily, and hospitalized, from 2005 to 2012. Demographic information, admission/discharge dates, discharge status, and up to 6 discharge diagnoses coded according to ICD-9 CM were collected for each hospitalized patient. During the 8-year study period, a total of 72 372 hospitalizations with at least one ICD-9 CM diagnosis code suggestive of all-cause pneumonia were recorded. Of these, 1943 (2.7%) hospitalizations had specific ICD-9 CM diagnosis codes for pneumococcal pneumonia. According to the proposed model, 16 541 (22.9%) pneumonia out of all-cause pneumonia was estimated to be attributable to S. pneumoniae. Pneumococcal pneumonia and model-estimated pneumococcal pneumonia had mean hospitalization rates of 13.4 and 113.3/100 000, respectively, with a decreasing temporal trend. The risk of hospitalization for pneumococcal pneumonia was strongly correlated with age (P<0.001). Our model provides data usable to construct suitable decisional models for the decision-makers and could allow to the responsibles of healthcare facilities to assess the budget impact if they hypothesize to offer vaccination for pneumococcal disease to certain cohorts of subjects aged 50 years or older. In our area, the high estimated hospitalization rates among adults aged ≥65 years suggest the need to implement effective preventive strategies (e.g., vaccination) tailored for these groups

Little evidence that Eurasian jays protect their caches by responding to cues about a conspecific’s desire and visual perspective

Eurasian jays have been reported to protect their caches by responding to cues about either the visual perspective or current desire of an observing conspecific, similarly to other corvids. Here, we used established paradigms to test whether these birds can – like humans – integrate multiple cues about different mental states and perform an optimal response accordingly. Across five experiments, which also include replications of previous work, we found little evidence that our jays adjusted their caching behaviour in line with the visual perspective and current desire of another agent, neither by integrating these social cues nor by responding to only one type of cue independently. These results raise questions about the reliability of the previously reported effects and highlight several key issues affecting reliability in comparative cognition research