Mining von BPMN-Prozessartefakten auf GitHub

Die Validierung von Programmanalysen und Analysewerkzeugen erfolgt häufig anhand einer Sammlung von Beispielprogrammen. Für eine aussagekräftige Bewertung sollte diese Sammlung repräsentativ sein. Gerade im Bereich der Analysen für domänenspezifische Sprachen wird zu diesem Zweck aber oft nur auf Fallstudien oder gar einzelne künstliche Programmbeispiele zurückgegriffen. In diesem Beitrag zeigen wir für die domänenspezifische Sprache BPMN, wie durch systematisches Mining auf GitHub.com ein Corpus von BPMN-Prozessen für die Validierung von Analysewerkzeugen generiert werden kann

An iron-based beverage, HydroFerrate fluid (MRN-100), alleviates oxidative stress in murine lymphocytes in vitro

BackgroundSeveral studies have examined the correlation between iron oxidation and H2O2 degradation. The present study was carried out to examine the protective effects of MRN-100 against stress-induced apoptosis in murine splenic cells in vitro. MRN-100, or HydroFerrate fluid, is an iron-based beverage composed of bivalent and trivalent ferrates.MethodsSplenic lymphocytes from mice were cultured in the presence or absence of MRN-100 for 2 hrs and were subsequently exposed to hydrogen peroxide (H2O2) at a concentration of 25 μM for 14 hrs. Percent cell death was examined by flow cytometry and trypan blue exclusion. The effect of MRN-100 on Bcl-2 and Bax protein levels was determined by Western blot.ResultsResults show, as expected, that culture of splenic cells with H2O2 alone results in a significant increase in cell death (apoptosis) as compared to control (CM) cells. In contrast, pre-treatment of cells with MRN-100 followed by H2O2 treatment results in significantly reduced levels of apoptosis. In addition, MRN-100 partially prevents H2O2-induced down-regulation of the anti-apoptotic molecule Bcl-2 and upregulation of the pro-apoptotic molecule Bax.ConclusionOur findings suggest that MRN-100 may offer a protective effect against oxidative stress-induced apoptosis in lymphocytes

Intermediate Representations of Mobile Code

Over the past decade, since Java was first introduced and integrated into the Netscape web browser, several intermediate representations have been developed that might be potentially used for mobile code applications. This paper examines the requirements for a mobile code representation, presents several examples of stack-based, tree-oriented, and proof-annotating mobile code representations, and evaluates each of these representations according to the requirements. Povzetek: Članek podaja pregled mobilnih kod.

Microbial oxidation of Fe2+ and pyrite exposed to flux of micromolar H2O2 in acidic media

At an initial pH of 2, while abiotic oxidation of aqueous Fe2+ was enhanced by a flux of H2O2 at micromolar concentrations, bio-oxidation of aqueous Fe2+ could be impeded due to oxidative stress/damage in Acidithiobacillus ferrooxidans caused by Fenton reaction-derived hydroxyl radical, particularly when the molar ratio of Fe 2+ to H2O2 was low. When pyrite cubes were intermittently exposed to fluxes of micromolar H2O2, the reduced Fe2+-Fe 3+ conversion rate in the solution (due to reduced microbial activity) weakened the Fe 3+-catalyzed oxidation of cubic pyrite and added to relative importance of H2O2-driven oxidation in the corrosion of mineral surfaces for the treatments with high H 2O2 doses. This had effects on reducing the build-up of a passivating coating layer on the mineral surfaces. Cell attachment to the mineral surfaces was only observed at the later stage of the experiment after the solutions became less favorable for the growth of planktonic bacteria