Dissociative electron attachment to carbon dioxide via the 8.2 eV Feshbach resonance

Momentum imaging experiments on dissociative electron attachment (DEA) to CO{sub 2} are combined with the results of ab initio calculations to provide a detailed and consistent picture of the dissociation dynamics through the 8.2 eV resonance, which is the major channel for DEA in CO{sub 2}. The present study resolves several puzzling misconceptions about this system

Variedades elite de capim-elefante com alto rendimento de biomassa no semiárido de Alagoas, Brasil.

O capim-elefante apresenta um dos maiores potenciais de produtividade de biomassa dentre todas as espécies de gramíneas forrageiras. No entanto, o déficit de água no solo é um dos fatores mais limitantes da produção maioria das espécies cultivadas. Neste contexto, o objetivo desta pesquisa foi avaliar o potencial de desenvolvimento e produção de biomassa de quatro variedades-elite de capimelefante (BRS Capiaçu, Madeira, Capim C6 e Capim C8) cultivadas sob irrigação, no município de Monteirópolis, região Agreste do Estado de Alagoas (bioma caatinga). As avaliações consistiram na determinação das produções de biomassa da parte aérea e da qualidade tecnológica deste material, em três ciclos de desenvolvimento, compreendidos no período de aproximadamente um ano. Além das produções de biomassa, ao final de ciclo, também foram determinados o número de perfilhos por metro linear e a estatura média das plantas de cada variedade. O maior índice de perfilhamento foi registrado na variedade Madeira (21,3 perfilhos m-1). As maiores relações folhas:colmo foram registradas nos cruzamentos C8 (0,73) e C6 (0,71) e na variedade Madeira (0,69). Os resultados demostram a grande capacidade de produção de biomassa das variedades de capim-elefante na região, associada ao rápido crescimento, a perenidade e a possibilidade de execução de múltiplos cortes anuais devido ao curto ciclo de desenvolvimento. As maiores produções médias anuais de biomassa seca foram registradas nos cruzamentos C6 e C8 (123,3 e 118,8 Mg ha-1 ano-1, respectivamente)

Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice.

Multiple myeloma is a largely incurable and life-threatening malignancy of antibody-secreting plasma cells. An effective and widely available animal model that recapitulates human myeloma and related plasma cell disorders is lacking. We show that busulfan-conditioned human IL-6-transgenic (hIL-6-transgenic) NSG (NSG+hIL6) mice reliably support the engraftment of malignant and premalignant human plasma cells, including from patients diagnosed with monoclonal gammopathy of undetermined significance, pre- and postrelapse myeloma, plasma cell leukemia, and amyloid light chain amyloidosis. Consistent with human disease, NSG+hIL6 mice engrafted with patient-derived myeloma cells developed serum M spikes, and a majority developed anemia, hypercalcemia, and/or bone lesions. Single-cell RNA sequencing showed nonmalignant and malignant cell engraftment, the latter expressing a wide array of mRNAs associated with myeloma cell survival and proliferation. Myeloma-engrafted mice given CAR T cells targeting plasma cells or bortezomib experienced reduced tumor burden. Our results establish NSG+hIL6 mice as an effective patient-derived xenograft model for study and preclinical drug development of multiple myeloma and related plasma cell disorders

Ejection dynamics and valve kinetics in patients with low-gradient severe aortic stenosis with preserved ejection fraction. Comparison between normal and low-flow

Abstract Background Studies of ejection dynamics in severe aortic stenosis and prosthetic valve obstruction had demonstrated a delay in aortic valve opening. Purpose The aim of this study was to compare and evaluate ejection dynamics and valve kinetics in patients with severe aortic stenosis with preserved ejection fraction with normal and low flow. Methods 83 patients (age average 68±11 years) with severe aortic stenosis (aortic valve area &amp;lt;1cm2) and preserved ejection fraction (≥50%) were studied with Doppler echocardiography and included prospectively. The ratio of aortic valve area measured at mid-deceleration and mid-acceleration (Md/Ma) were calculated using velocity of left ventricular outflow tract and aortic transvalvular velocity in continuity equation as an index of valvular kinetics. A ratio of Md/Ma &amp;gt;1 indicate delay in opening of aortic valve. Assessment of ejection dynamics was evaluated with acceleration time (AT), ejection time (ET) and the ratio AT/ET estimated from aortic Doppler velocities profiles. Aortic flow was calculated as stroke volume/ET. According to stroke volume index and mean gradient patients were classified in 3 groups: normal-flow, low-gradient (NFLG) 25 patients, low-flow, low-gradient (LFLG) 28 patients and normal-flow, high-gradient (HG) 30 patients. Analysis of the variance and coefficient of correlation “r” were used for statistical evaluation. A p value &amp;lt;0.05 was considered significant. Results There was no significant difference among the 3 groups with regard to ratio Md/Ma: NFLG 1.29±0.38, LFLG 1.22±0.26 and HG 1.23±0.45, NS. No difference was found in AT in the 3 groups, but ET was shorter in LFLG (310±30 ms) in comparison with NFLG (345±32 ms) and HG (361±31 ms), p&amp;lt;0.01. Ratio AT/ET occurred in early systole in NFLG (0.27±0.07) compared with LFLG (0.32±0.07) and HG (0.39±0.07), p&amp;lt;0.01. As expected, flow was decreased in LFLG (163±20 ml/s, p&amp;lt;0.001) compared with NFLG (217±13 ml/s) and HG (233±44 ml/s). There was no correlation among AT/ET and aortic flow or stroke volume index. Conclusions There were not differences among the groups with regard to kinetic of the valve evaluated by mean of ratio Md/Ma. According to ratio AT/ET, aortic valve takes less time to open in NFLG compared with LFLG and HG independent of aortic flow suggesting a different ejection dynamics pattern in this group. Funding Acknowledgement Type of funding source: None </jats:sec