Course of acute coronary syndrome in patients with fraillty

The goal of this study was to study the course and outcome of acute coronary syndrome with ST-segment elevation and without ST-segment elevation in patients of older age groups with frailt

Distance learning: from an online lesson to a digital preparatory faculty

The purpose of the article is to identify the possibilities of distance teaching of Russian as a foreign language and the prospects for the development of online courses within the digital preparatory facult

Levosalbutamol as alternative to drugs on the basis of racemic salbutamol: Review of the results of pre-clinical research

The aim of the work is to conduct an analytical review of the results of preclinical studies of levosalbutamol. The review discusses the pharmacodynamic features of the R-stereoisomer of salbutamol in vitro. The chemical bases of interaction of levosalbutamol with β2-adrenoreceptors, intracellular signaling cascades associated with β2-adrenoreceptors, and structural features of clinically significant ligands of β2-adrenoreceptors are presented. Broncholytic activity, influence on the contractility of the diaphragmatic muscles, mucociliary clearance of R-salbutamol in comparison with racemic salbutamol are described. The data presented indicate that all known β2-adrenergic receptor-dependent effects of racemic salbutamol, including bronchodilation, are realized by its R-enantiomer. There is evidence that the regular inhalation administration of racemic salbutamol is accompanied by a partial decrease in the bronchoprotective effect and an increase in airway hyperreactivity in response to the action of provocative factors. It was found that the development of hyperreactivity of the respiratory tract is excluded in the case of regular inhalation of levosalbutamol. Possible mechanisms of the paradoxical bronchoconstrictor effect of the salbutamol dystomer are described. This article shows the beneficial effect of levosalbutamol on mucociliary clearance, its anti-inflammatory activity and antiallergic effect. The image data are compared between the enantiomers and the racemate of salbutamol. Special attention is paid to the pharmacokinetics of enantiomers of salbutamol. The data presented from the preclinical studies provide evidence of chiral inversion of stereoisomers of salbutamol

КАШЕЛЬ У ДЕТЕЙ С ОСТРЫМИ РЕСПИРАТОРНЫМИ ИНФЕКЦИЯМИ: ВОЗМОЖНОСТИ ОФИЦИНАЛЬНОЙ ФИТОТЕРАПИИ

Effective and safe treatment of acute respiratory infections is one of the urgent issues of pediatrics. The most common and primary symptom of acute and chronic respiratory diseases and one of the most frequent causes of hospital visits among both children and adults is cough. Pharmacotherapy of cough involves use of the drugs improving bronchial drainage function and restoring adequate mucociliary clearance; use of antitussive drugs when indicated; antibiotic therapy in the event of the confirmed bacterial infection. The article presents data on the use of ready-made forms of phytopreparations for respiratory diseases. In particular, it demonstrates effectiveness of plantain syrup (for dry cough) and primula syrup (for productive cough). Проблема эффективного и безопасного лечения острых инфекций дыхательных путей является одной из актуальных в клинической педиатрии. Наиболее распространенным и основным симптомом острых и хронических заболеваний органов дыхания, одной из частых причин обращений к врачу как детей, так и взрослых пациентов является кашель. Фармакотерапия кашля включает применение препаратов, улучшающих дренажную функцию бронхов и восстанавливающих адекватный мукоцилиарный клиренс; применение противокашлевых препаратов по показаниям; использование антибактериальной терапии при доказанной бактериальной инфекции. В статье представлены данные об использовании готовых форм растительных препаратов при заболеваниях органов дыхания. В частности продемонстрирована эффективность сиропа подорожника (для сухого кашля) и сиропа первоцвета (для влажного кашля). Ульян, этого нет в анг варианте. Может, мы вообще не будем отправлять Кате авторские переводы резюме? Чтобы она потом сразу Осиповские вставляла?

Model for Predicting Risk of Postpartum Purulent-Inflammatory Complications after Cesarean Section: Cohort Retrospective Study

Background. Relevance of the study is related to the lack of a unified strategy for determining the risk of infectious complications of puerperium. Currently, the specialists use the collected data from studies documenting the main factors of infection in a population or cohorts of postpartum women. However, accuracy of these factors is not established and prognosis could not be personalized. The paper analyzes significant risk factors for the infectious complications associated with cesarean section (C-Section) and develops a model for their prognosis and an individual assessment of the risk of postpartum infection in order to take timely preventive measures. Objective. To identify predictors of postpartum purulent-inflammatory complications after cesarean section, to evaluate their predictive value, and to develop a statistical model for determining the risk of their occurrence.Methods. The cohort retrospective study (January 2019 to January 2022) was conducted in four obstetric health facilities of Krasnodar and was focused on analysis of medical records. Anamnestic, clinical and laboratory data of all women after cesarean section delivery were collected. Model: a patient diagnosed with any infection associated with cesarean section within 42 days after delivery — postoperative suture infection, endometritis, peritonitis, thrombophlebitis, sepsis. Infections were grouped to carry out a single risk assessment with an internal validation test and to develop a multifactor logistic regression model. All analyses were conducted using version R 3.2.3 (SPSS Inc., Chicago, IL) and Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD).Results. Infection associated with cesarean section occurred in 2.50% of women (n = 548; 95% CI 2.6–3.5), suture disruption — in 0.59% (n = 129; 95%, CI 0.41–0.81), endometritis — 1.46% (n = 321; 95%, CI 1.15–1.94), peritonitis — 0.16% (n = 35; 95%, CI 0.11–0.20), thrombophlebitis 0.04% (n = 9; 95%, CI 0.01–0.05), sepsis 0.25% (n = 54; 95%, CI 0.15–0.35). The authors have identified 14 major variables with a high prognostic risk for the development of infectious complications of puerperium. The model differentiated women with and without purulent inflammatory complications of puerperium by internal validation (concordance index = 0.712, 95%, CI 0.672–0.755).Conclusion. The developed model can be used to accurately predict the risk of infectious complications after abdominal delivery and to identify high-risk patients. It ensures a differentiated approach with a possibility to expand studies and strengthen antibiotic therapy, which promotes reduction of surgical site puerperal infection

The Fundamental Study of Arima Bamboo Industry (2)

A chair conformation with an axial orientation of the phosphoryl or thiophosphoryl group is preferable for 2-dimethylamino-2-oxo- and-2-thiono-1,3,2-oxathiaphosphorinanes. The cis isomer of 2-dimethylamino-2-oxo-4-methyl-1,3,2-oxathiaphosphorinane has a similar structure with an equatorial orientation of the 4-methyl group, while the corresponding sulfide is characterized by a trans configuration with a reoriented positioning of the substituents attached to the phosphorus atom. © 1989 Plenum Publishing Corporation