147 research outputs found
Gaziantep Sanayisi ve Dinamikleri
This paper aims to contribute understanding of industrial dynamics of Gaziantep Province. The analysis is based on the survey data obtained in the research project named Industrial Inventory of SEAP and Transformation Tendencies in Industry funded by TUBITAK. The survey data was obtained by face to face interviews in 2057 companies in Gaziantep. But, the response rate was % 51,35 , in other words, 1056 companies were included in this paper. The inquiry consisted of 120 questions that are either multiple choice or short answer. For this study, 40 variables were chosen from the survey results which might indicate industrialization dynamics of Gaziantep. SPSS software version 15.0 was used to perform statistical analysis. First, frequency distribution tables were composed for each question and comparisons through cross-tabulations were performed to assess relations between categorical variables. At this stage, main findings were discussed and illustrated with summary tables and figures. Then, a logistic regression model was created and to formalize the study, variables that can possibly have influences on the competitiveness and export dynamics of the companies in Gaziantep were determined. According to this analysis; working capital, capacity use ratio, firm scale, ownership of firms' property, computerization of firms and educational attainment are found to be important variables for competitiveness of the firms in the district of Gaziantep
Reliability and validity of the Turkish translation of the beliefs about medicines questionnaire (BMQ-T) in patients with Behçet’s disease
OBJECTIVES: The aim of this study was to evaluate the reliability and validity of the Turkish translation of the Beliefs about Medicines Questionnaire (BMQ-T, ©Prof. Rob Horne) for patients with Behçet's disease. METHODS: This methodological study enrolled a sample of 125 patients. The scale was adapted to Turkish through a process including translation, comparison with versions in other languages, back translation, and pretesting. Construct validity was evaluated by factor analysis. Medication adherence evaluated as poor, moderate and good according to the Morisky Medication Adherence Scale (MMAS). BMQ-T scores compared along medication adherence status groups. RESULTS: In our study, as in the original scale, the factor analysis confirmed that the BMQ-T had a four-factor structure explaining 54.73% of the total variance. The BMQ-T had acceptable internal consistency (Cronbach's alpha coefficient: Specific Necessity=.812; Specific Concerns=.672; General Harm=.677; General Overuse=.656), adequate test-retest reliability (intraclass correlation coefficients: Specific Necessity=.715; Specific Concerns=.680; General Harm=.678; General Overuse=.327). Specific Necessity and Specific Concerns scores were significantly different between medication adherence status groups. CONCLUSIONS: The psychometric properties of the BMQ-T were consistent with those reported in the original study. The BMQ-T was found to be a valid and reliable tool for evaluating beliefs about medicines in patients with Behçet's disease
Cultura de Inovação: Conceitos e Modelos Teóricos
This study portrays the state of the art in scientific literature on the culture of innovation, with the objective of
characterizing its meaning and especially describing different theoretical models that seek to understand how it
occurs in an organizational environment. To enrich the analysis, research results show the relationship between
organizational culture and innovation. The literature review was carried out in 2011 using the following databases:
Coordination for the Improvement of Higher Education Personnel (CAPES), Proquest and Directory of Open
Access Journals (DOAJ). The keywords used were the expression culture of innovation and the joint terms
culture and innovation, only full articles were included in the research. Culture of innovation articles that were
cited in the papers identified in the literature search were also considered. The analysis consisted of 40 articles,
based on the predefined criteria, and showed that this is a topic of interest for researchers in different world regions.
It is a complex theme determined by factors with a systemic character. There is a predominance of quantitative
research and strong evidence of a relationship between organizational culture and innovation, which requires
further research to test the theoretical models proposed by these different authors
Adaptation of Scheffersomyces stipitis to hardwood spent sulfite liquor by evolutionary engineering
Hardwood spent sulfite liquor (HSSL) is a by-product of acid sulfite pulping process that is rich in
xylose, a monosaccharide that can be fermented to ethanol by Scheffersomyces stipitis. However, HSSL also contains
acetic acid and lignosulfonates that are inhibitory compounds of yeast growth. The main objective of this study
was the use of an evolutionary engineering strategy to obtain variants of S. stipitis with increased tolerance to HSSL
inhibitors while maintaining the ability to ferment xylose to ethanol
Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies
Congenital insensitivity to pain (CIP) and hereditary sensory and autonomic neuropathies (HSAN) are clinically and genetically heterogeneous disorders exclusively or predominantly affecting the sensory and autonomic neurons. Due to the rarity of the diseases and findings based mainly on single case reports or small case series, knowledge about these disorders is limited.
Here, we describe the molecular workup of a large international cohort of CIP/HSAN patients including patients from normally under-represented countries. We identify 80 previously unreported pathogenic or likely pathogenic variants in a total of 73 families in the >20 known CIP/HSAN-associated genes. The data expand the spectrum of disease-relevant alterations in CIP/HSAN, including novel variants in previously rarely recognized entities such as ATL3-, FLVCR1- and NGF-associated neuropathies and previously under-recognized mutation types such as larger deletions. In silico predictions, heterologous expression studies, segregation analyses and metabolic tests helped to overcome limitations of current variant classification schemes that often fail to categorize a variant as disease-related or benign.
The study sheds light on the genetic causes and disease-relevant changes within individual genes in CIP/HSAN. This is becoming increasingly important with emerging clinical trials investigating subtype or gene-specific treatment strategies
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