Monosensitize ve polisensitize hastalarda bazofil duyarlılığının kantitatif CD63 ölçümü ile karşılaştırılması

The aim of the study was to determine the prevalance of monosensitized and polysensitized olive pollen allergic patients. In addition to determine the efficacy of allergoid immunotherapy in monosensitized olive pollen allergy. 441 patients diagnosed with allergic rhinitis and/or asthma have been admitted to the study. Of whom 212 (48%) patients diagnosed with olive pollen allergy and 33 (7.5%) patients diagnosed with monosensitized. 20 of 33 olive monosensitized patients have been treated with olive pollen spesific allergoid immunotherapy. After one year of the treatment nasal symptom score, wheal diameter with olive allergen and the ratio of basophils with CD63 expression were diminished.Zeytin monosensitize ve polisensitize alerjik hastaların sıklığı ve bazofil aktivasyon testinin tanıdaki değeri ve zeytin spesifik alergoid immünoterapisinin klinik, immünolojik ve bazofiller üzerindeki etkinliği belirlenmeye çalışılmıştır. Alerjik rinokonjonktivit ve/veya astım tanıları ile başvuran ve prik testi pozitif bulunan 441 hastanın 212’sinde (%48) zeytin duyarlığı saptanmıştır. 33 hastada (%7.5) sadece zeytin polenine duyarlılık saptanmıştır. Sadece zeytin polenine duyarlı olan 33 hasta ile zeytin dışı alerjenlere duyarlı olan 20 hastada zeytin spesifik bazofil aktivasyon testi yapıldı. Sadece zeytine duyarlı 20 hastaya mevsim öncesi zeytin spesifik allergoid immünoterapisi uygulandı ve zeytin spesifik bazofil aktivasyon testi yapıldı. İmmünoterapi grubunda 1. yılın sonunda nazal semptom skoru (p=0.001), zeytin poleni ile prik testinde elde edilen endurasyon çapları (p=0.005), CD63 eksprese eden bazofil yüzdesi azalmış (p=0.0001) olarak saptandı. Zeytin poleni alerjisinin invitro tanısında bazofil aktivasyon testinin duyarlılık ve özgüllüğü yüksek güvenilir bir test olduğu bulundu. Alergoid immünoterapisi ile zeytin poleni alerjik bireylerde klinik semptomlarda iyileşme ve zeytin polen spesifik invitro ve invivo testlerde klinik iyileşmeye parallel bulgular kaydedildi

Evaluation of Inferior Turbinate Stroma with Ultrasound Elastography in Allergic Rhinitis Patients

Background: Diagnosis of allergic rhinitis is primarily based on history, physical examination and allergy testing. A technique that noninvasively evaluates the soft tissue changes in the nasal mucosa of allergic rhinitis patients has not been defined. Aims: To assess nasal mucosal changes and measure the submucosal fibrosis in allergic rhinitis patients with sonoelastography. Study Design: Case control study. Methods: Eighty-eight turbinates of 44 patients were included in the study. There were 23 prick test positive allergic rhinitis patients. the control group constituted 21 patients. the rhinitis quality of life questionnaire and the visual analogue scale were applied to the allergic rhinitis patients. A higher visual analogue scale score indicated more severe allergic rhinitis symptoms. Sonoelastographic measurements were made from the lateral nasal wall. the propagation speed of sound waves was recorded in m/s. the presence of asthma and the type of allergic rhinitis (seasonal or perennial) was noted. Results: Ten patients had seasonal allergic rhinitis and thirteen patients had perennial allergic rhinitis. Six patients (26.1%) had accompanying asthma along with allergic rhinitis. the median visual analogue scale score was 7 (3-9) in allergic rhinitis patients. the median symptom duration was 7 (1-24) months. the median quality of life questionnaire score was 3.39 (1.68-5.43) points. the median sonoelastography scores of allergic rhinitis patients and healthy subjects were 2.38 m/s (0.9-4.47) and 2.42 m/s (1.62-3.50), respectively. Sonoelastographic measurements of seasonal and perennial allergic rhinitis patients did not differ significantly (p>0.05). the presence of asthma did not have a significant impact on the elastography measurements (p>0.05). However, regression analysis revealed a significant inverse correlation (coefficients: B=0.005, standard error=0.097, beta 0=0.008) between the visual analogue scale and sonoelastography scores (p<0.05). Conclusion: Sonoelastography was not suitable as a diagnostic tool in allergic rhinitis. Reduced sonoelastography scores were measured in more symptomatic patients. Higher visual analogue scale scores could be an indicator of disease severity