Relationship between Hba1c and blood glucose level in hemodialysis patients with diabetes mellitus

Within in the scope of this study, a researchwas aimed at the relationship between HbA1c markersand blood glucose levels with DM, chronic renal failureand receiving dialysis treatment.Methods: In this study, monthly glucose levels and quarterlyHbA1c markers of 131 patients (53 female, 78 male)receiving dialysis treatment in a private dialysis centerbetween January 1, 2009-July 31, 2010 were evaluatedretrospectively.Results: The average age of 131 cases was 63.3±11.2years (range, 30-91). Gender distribution of the cases: 53female (40.5%), 78 male (59.5%). While the age averageof the females was 62.2±11.2 and the males’ was64.1±11.2. The average glucose level of the females andmales have a correlation to average HbA1c (Female:p<0.001, r=0.761, Males: p<0.001, r=0.743). The averageglucose level of the both case groups have a correlationto average HbA1c (p<0.001, r=0.755). While 32.8%of the examined HbA1c results were observed underthe level 6,5%, and 67.2% of the examined results wereobserved above the level 6.5%. While 18.3% of the preprandialblood glucose levels were obtained under 126mg/dl level, and 81.3% of the results were obtained above126 mg/dl level. It has been observed that the mean bloodglucose level has a correlation to average HbA1c level.Conclusion: The measurement of HbA1c and blood glucose(pre-prandial and postprandial) and the correlationbetween them, by virtue of the fact that, are vitally importantin cardiovascular mortality and morbidity, monitorof DM for the dialysis patients with diabetic nephropathy.Key words: Hemodialysis, diabetes mellitus, HbA1

Type-specific dendritic integration in mouse retinal ganglion cells

Neural computation relies on the integration of synaptic inputs across a neuron’s dendritic arbour. However, it is far from understood how different cell types tune this process to establish cell-type specific computations. Here, using two-photon imaging of dendritic Ca2+ signals, electrical recordings of somatic voltage and biophysical modelling, we demonstrate that four morphologically distinct types of mouse retinal ganglion cells with overlapping excitatory synaptic input (transient Off alpha, transient Off mini, sustained Off, and F-mini Off) exhibit type-specific dendritic integration profiles: in contrast to the other types, dendrites of transient Off alpha cells were spatially independent, with little receptive field overlap. The temporal correlation of dendritic signals varied also extensively, with the highest and lowest correlation in transient Off mini and transient Off alpha cells, respectively. We show that differences between cell types can likely be explained by differences in backpropagation efficiency, arising from the specific combinations of dendritic morphology and ion channel densities

Fractional free space, fractional lenses, and fractional imaging systems

Continuum extensions of common dual pairs of operators are presented and consolidated, based on the fractional Fourier transform. In particular, the fractional chirp multiplication, fractional chirp convolution, and fractional scaling operators are defined and expressed in terms of their common nonfractional special cases, revealing precisely how they are interpolations of their conventional counterparts. Optical realizations of these operators are possible with use of common physical components. These three operators can be interpreted as fractional lenses, fractional free space, and fractional imaging systems, respectively. Any optical system consisting of an arbitrary concatenation of sections of free space and thin lenses can be interpreted as a fractional imaging system with spherical reference surfaces. As a special case, a system departing from the classical single-lens imaging condition can be interpreted as a fractional imaging system

A significant interaction between moxifloxacin and warfarin in a patient with a mitral bioprosthetic valve

PubMedID: 18649061Moxifloxacin is an advanced-generation fluoroquinolone with a broad spectrum of antimicrobial activity that is not metabolized by cytochrome P450 system. Therefore, the drug interaction of moxifloxacin is rarely seen. It has been reported that moxifloxacin is safe and well tolerable. We aimed to report a drug interaction between moxifloxacin and warfarin in a 74-year-old patient with a prosthetic mitral valve. © Springer Japan 2008

Treatment adherence and related factors in Parkinson's disease patients without dementia

Background and Objective: Patients with Parkinson’s Disease (PD) have many risk factors for treatment nonadherence, such as cognitive impairment, depression, polypharmacy, and medication regimen complexity. Adherence in PD should be carefully monitored to accurately assess the patient’s clinical and treatment responseMethod: This is a cross-sectional observational study. Sixty patients who were diagnosed with PD according to the UK PD Association’s Brain Bank criteria and had at least primary school education participated in our study. Patients with a diagnosis of dementia or who received deep brain stimulation, apomorphine infusion, and levodopa/carbidopa intestinal gel therapy were excluded from the study. Main outcome measures: Adherence was evaluated with the 4-item Morisky medication adherence scale. The course of the patients was gauged with the MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). MDS-UPDRS subscores are as follows; Part 1: nonmotor experiences of daily life Part 2: motor experiences of daily life Part 3: motor examination Part 4: motor complications. In the evaluation of patients, Schwab and England Activities of Daily Living Rating Scale (SE-ADL) was used for activities of daily living, MoCA for cognitive status, Beck Depression and anxiety scales for mood. The number of drugs used by the patients and LDED were calculated. Results: The mean age of the patients was 62.40 (± 10.25) and 70% of them were male (n:42). There was no significant difference between the adherence of the patients according to the Hoehn and Yahr stages. There was a significant correlation between adherence and depression (p 0.005, r - 0.372), anxiety (0.009 r - 0.357), UPDRS-1 (p 0.006 r - 0.373), UPDRS-2 (p 0.027 r - 0.304), SEADL (p 0.001, r 0.438) scores. When these variables were included in the regression analysis with the enter method, SE-ADL score were found to be significant for predicting adherence (p 0.041, OR 0.328). Conclusion: Motor and non-motor problems of daily life are associated with non-adherence in PD patients without dementia. Treatment of non-motor symptoms such as depression and anxiety may contribute to adherence. Higher independence of patients in daily life increases adherence

P53 codon 72 polymorphism is associated with susceptibility to hepatocellular carcinoma in the Turkish population: A case-control study

PubMedID: 21607615The tumor suppressor p53 gene plays a crucial role in preventing carcinogenesis through its ability to induce cell cycle arrest and apoptosis following DNA damage and oncogene activation. A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein. Arg72 and Pro72 allele are different from a biochemical and biological point of view and many reports suggest that they can modulate individual cancer susceptibility. To determine the association of the p53 Arg72Pro polymorphism with the risk of hepatocellular carcinoma (HCC) development in a Turkish population, a hospital-based case-control study was designed consisting of 119 subjects with HCC and 119 cancer-free control subjects matched for age, gender, smoking and alcohol status. The genotype frequency of the p53 Arg72Pro polymorphism was determined by using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Our data shows that the Pro/Pro genotype of the p53 Arg72Pro polymorphism is associated with increased risk of HCC development in this Turkish population (OR = 3.20, 95% CI: 1.24-8.22, P = 0.02). Furthermore, according to stratified analysis, a significant association was observed between the homozygote Pro/Pro genotype and HCC risk in the subgroups of male gender (OR = 3.01, 95% CI: 1.14-7.97, P = 0.03) and patients with hepatitis B virus (HBV)-related HCC (OR = 4.04, 95% CI: 1.46-11.15, P = 0.007). Because our results suggest for the first time that the Pro/Pro homozygote of p53 Arg72Pro polymorphism may be a genetic susceptibility factor for HCC (especially in the male gender and HBV-infected patients) in the Turkish population, further independent studies are required to validate our findings in a larger series, as well as in patients of different ethnic origins. © 2011 Springer Science+Business Media B.V.TF2007LTP16Acknowledgments This study was funded by C¸ ukurova University Research Fund TF2007LTP16. The authors thank all the subjects who participated in this study

Festuca albomontana (Poaceae), a new chasmophytic fescue from the Western Taurus Mountains (Antalya, Turkey)

A new species of Festuca from the Western Taurus Mountains (Antalya, Turkey) is described here and named F. albomontana. The new species can clearly be distinguished from the other species included in the F. alpina group by its leaf anatomical features. It has a geographically isolated position in the Western Tauruses whereas a closely related species, F. sommieri, is very local in the Black Sea Region of Turkey. It is suggested that it should be in the "critically endangered" threat category according to the International Union for Conservation of Nature (IUCN) criteria. Observations on the ecology of the population are noted. © 2022 Sciendo. All rights reserved.FBA-2018-3773We wish to thank the Akdeniz University Scientific Research Projects Unit (Project number: FBA-2018-3773) for financial support of this study. We also would like to thank the curators of the AKDU, E, G, GJ, MW, W, WU and NMHN for access to specimens