Slitless spectrophotometry with forward modelling: principles and application to atmospheric transmission measurement

In the next decade, many optical surveys will aim to tackle the question of dark energy nature, measuring its equation of state parameter at the permil level. This requires trusting the photometric calibration of the survey with a precision never reached so far, controlling many sources of systematic uncertainties. The measurement of the on-site atmospheric transmission for each exposure, or on average for each season or for the full survey, can help reach the permil precision for magnitudes. This work aims at proving the ability to use slitless spectroscopy for standard star spectrophotometry and its use to monitor on-site atmospheric transmission as needed, for example, by the Vera C. Rubin Observatory Legacy Survey of Space and Time supernova cosmology program. We fully deal with the case of a disperser in the filter wheel, which is the configuration chosen in the Rubin Auxiliary Telescope. The theoretical basis of slitless spectrophotometry is at the heart of our forward model approach to extract spectroscopic information from slitless data. We developed a publicly available software called Spectractor (https://github.com/LSSTDESC/Spectractor) that implements each ingredient of the model and finally performs a fit of a spectrogram model directly on image data to get the spectrum. We show on simulations that our model allows us to understand the structure of spectrophotometric exposures. We also demonstrate its use on real data, solving specific issues and illustrating how our procedure allows the improvement of the model describing the data. Finally, we discuss how this approach can be used to directly extract atmospheric transmission parameters from data and thus provide the base for on-site atmosphere monitoring. We show the efficiency of the procedure on simulations and test it on the limited data set available.Comment: 30 pages, 36 figures, submitted to Astronomy and Astrophysic

40S hnRNP particles are a novel class of nuclear biomolecular condensates.

Heterogenous nuclear ribonucleoproteins (hnRNPs) are abundant proteins implicated in various steps of RNA processing that assemble on nuclear RNA into larger complexes termed 40S hnRNP particles. Despite their initial discovery 55 years ago, our understanding of these intriguing macromolecular assemblies remains limited. Here, we report the biochemical purification of native 40S hnRNP particles and the determination of their complete protein composition by label-free quantitative mass spectrometry, identifying A-group and C-group hnRNPs as the major protein constituents. Isolated 40S hnRNP particles dissociate upon RNA digestion and can be reconstituted in vitro on defined RNAs in the presence of the individual protein components, demonstrating a scaffolding role for RNA in nucleating particle formation. Finally, we revealed their nanometer scale, condensate-like nature, promoted by intrinsically disordered regions of A-group hnRNPs. Collectively, we identify nuclear 40S hnRNP particles as novel dynamic biomolecular condensates

Quantum control of a cat-qubit with bit-flip times exceeding ten seconds

Binary classical information is routinely encoded in the two metastable states of a dynamical system. Since these states may exhibit macroscopic lifetimes, the encoded information inherits a strong protection against bit-flips. A recent qubit - the cat-qubit - is encoded in the manifold of metastable states of a quantum dynamical system, thereby acquiring bit-flip protection. An outstanding challenge is to gain quantum control over such a system without breaking its protection. If this challenge is met, significant shortcuts in hardware overhead are forecast for quantum computing. In this experiment, we implement a cat-qubit with bit-flip times exceeding ten seconds. This is a four order of magnitude improvement over previous cat-qubit implementations, and six orders of magnitude enhancement over the single photon lifetime that compose this dynamical qubit. This was achieved by introducing a quantum tomography protocol that does not break bit-flip protection. We prepare and image quantum superposition states, and measure phase-flip times above 490 nanoseconds. Most importantly, we control the phase of these superpositions while maintaining the bit-flip time above ten seconds. This work demonstrates quantum operations that preserve macroscopic bit-flip times, a necessary step to scale these dynamical qubits into fully protected hardware-efficient architectures

Clonal Groupings in Serogroup X Neisseria meningitidis

The genetic diversity of 134 serogroup X Neisseria meningitis isolates from Africa, Europe, and North America was analyzed by multilocus sequence typing and pulsed-field gel electrophoresis. Although most European and American isolates were highly diverse, one clonal grouping was identified in sporadic disease and carrier strains isolated over the last 2 decades in the United Kingdom, the Netherlands, Germany, and the United States. In contrast to the diversity in the European and American isolates, most carrier and disease isolates recovered during the last 30 years in countries in the African meningitis belt belonged to a second clonal grouping. During the last decade, these bacteria have caused meningitis outbreaks in Niger and Ghana. These results support the development of a comprehensive conjugate vaccine that would include serogroup X polysaccharide

Déterminants structuraux de la reconnaissance spécifique de l'ADN par le domaine THAP de hTHAP1 et implications dans la dystonie DYT6

TOULOUSE3-BU Sciences (315552104) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

Transition-Metal-Catalyzed Uninterrupted Four-Step Sequence to Access Trisubstituted Isoxazoles

International audienceWe describe herein a novel uninterrupted four-step sequence to access trisubstituted isoxazoles from readily available propargylic alcohols using sequentially iron and palladium catalytic systems. The advantages of such a strategy are illustrated by the high overall yields and the time-saving procedure that are reported

Porous textile composites (PTCs) for the removal and the decomposition of chemical warfare agents (CWAs) – A review

International audienceSince the first use of a chemical warfare agent (CWA), specific methods of protection have been developed to protect human body from such lethal compounds. The first protection systems rely on impermeable clothing or the capture of the toxics species by an adsorbent such as activated carbon. However, both present important limitations, i.e. heat stress for impermeable protection and a risk of saturation or release of toxic compounds for the adsorbent. The optimal protection should therefore be active, i.e. be able to both capture and detoxify CWAs. In this optic, this review describes active porous textiles composites (PTC) used as protective garments against CWAs. To this day, a large variety of porous compounds such as zeolites, metal organic frameworks (MOFs) or aerogels have shown catalytic degradation of CWAs. The integration of these active solids to textile fibers is then detailed, highlighting the importance of the electrospinning technique or the pre-functionalization of fibers. Concerning the detoxification process, MOFs have focused a large part of the PTC research due to their exceptional properties (high surface area and tunable porosity combined to a catalytic activity). More particularly, Zr-based MOFs exhibit exceptional results in terms of CWA detoxification and are currently highly studied. Besides, this present state of art includes other active PTCs (functionalized activated carbon fibers ACFs or zeolite composites) rarely discussed in reviews, to give a full overview of the existing PTC used against CWA