Identification of C38 colon adenocarcinoma growth under bevacizumab therapy and without therapy

Model identification allows to design different con- trol strategies for antiangiogenic cancer therapy, and create model-based treatment protocols. These model-based protocols can be more effective than the current ones, since they provide individual treatment for the patients. The aim of this paper is to investigate C38 colon adenocarcinoma growth in three different cases: (1) tumor growth without therapy, (2) tumor growth with one Avastin dose for a 18-day therapy (10 mg/kg), (3) tumor growth with one-tenth dose of control Avastin dose spread over 18 days. Parametric model identification was carried out for these three cases and the relationship between the measured tumor attributes (volume, mass and vascularization) was analyzed. Effect of low-dose therapy was also examined

Mössbauer study of FINEMET with different permeability

Stress field and magnetic field annealed FINEMET ribbons were investigated by 57Fe Mössbauer spectroscopy, magnetic and XRD methods. The change in relative areas of the 2nd and 5th lines in the Mössbauer spectra indicated significant variation in magnetic anisotropy due to the different annealing. High velocity resolution Mössbauer spectroscopy was also used to control the model applied for the evaluation of Mössbauer spectra. A correlation was found between the permeability and the magnetic anisotropy of the annealed FINEMET samples. This can be applied to predict production parameters of FINEMET ribbons with more favorable soft magnetic properties for technological applications. © 2012 Springer Science+Business Media Dordrecht

Giant synovial cell sarcoma of the thorax in a 46-year-old man: a case report

Background:Although synovial cell sarcoma is a common tumor of the extremities, its occurrence in the thorax has been less frequently documented. Case Presentation: A 46-year-old Pakistani man presented with a 2 month history of progressively increasing cough and left lower chest pain. Initial evaluation was done using a chest x-ray, the Patient was found to have a large mass involving the lower portion of the left chest. A computed tomography scan was performed next which showed a large mass involving the left chest wall with invasion into the pericardium and left hemidiaphragm. En bloc surgical resection of the tumor was undertaken. Final pathology showed synovial cell sarcoma of the thorax. At one-year follow-up, the Patient has shown no recurrence of the disease. Conclusions: We have described a rare case of a large synovial cell sarcoma of the thorax. Surgical resection appears an appropriate modus operandi for managing giant synovial cell sarcomas of the thorax. However, there is a need to clearly define post-operative strategies for cases with extensive involvement of surrounding structures

Spectroscopic studies on self-supporting multi-wall carbon nanotube based composite films for sensor applications

Self-supporting composite buckypapers containing 50 wt% multi-wall carbon nanotubes (MWCNTs) and SnOx or VOx were prepared by filtration using two different methods. Either the metal-oxides were pre-prepared and mixed with the nanotubes only before filtration (co-filtration method), or the MWCNTs were placed into the synthesis autoclaves of the oxides (single-step method) and the buckypaper was filtered from the product of this synthesis. The resulting composites were characterized by high resolution scanning electron microscopy, XPS, IR and Raman spectroscopy. Whereas the co-filtered samples are simple mechanical mixtures of their individual components, in case of the single-step composites we have found evidence for the existence of an interfacial region between the carbon nanotubes and the metal oxides. This is verified by the appearance of Sn and V in lower oxidation state from the metal-oxide side as well as by the presence of a low-frequency shoulder of the Raman G-band from the carbon nanotube side. The latter feature resembles a Breit Wigner Fano type line which is characteristic for phonon coupling to an electronic continuum

Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability.

Giant cell tumour of bone, a benign but potentially aggressive neoplasm, shows an increasing rate of chromosomal aneusomy that correlates with clinical course. Mechanisms that generate chromosomal instability in giant cell tumour of bone are poorly understood. One possible cause of chromosomal instability is an error in mitotic segregation due to numeric and/or functional abnormalities of centrosomes. Centrosome alteration is a common phenomenon in many cancers and has a major role in the development of chromosomal instability in cancer cells. To gain an insight into the possible mechanism for the generation of chromosomal instability in giant cell tumour of bone, we analysed 100 cases, including 57 primary nonrecurrent, 35 recurrent and 8 malignant giant cell tumour of bone cases. gamma-Tubulin immunohistochemistry was performed on tissue microarrays of 59 formalin-fixed paraffin-embedded cases, whereas pericentrin and gamma-tubulin fluorescent immunocytochemistry was carried out on 41 frozen smears. Fluorescent in situ hybridization was performed on 23 cases of pericentrin immunostained smears, allowing the simultaneous analysis of centrosomes and chromosome aberrations. Centrosome amplification was significantly higher in recurrent and malignant giant cell tumour of bones compared with nonrecurrent tumours (P<0.001). A comparison of the percentage of aneusomic cells with a normal centrosome content (4.7%) with that of aneusomic cells with centrosome amplification (6.4%) revealed no significant association between chromosome number alterations and centrosome aberrations (P=0.31). These findings indicate that centrosome alteration and frequency of aneusomy correlate with clinical behaviour; the lack of an association between centrosome amplification and chromosome number alteration suggests that alternative causative mechanisms produce genetic instability in giant cell tumour of bone

Sebészi radikalitás és rekonstrukciós lehetőségek végtagi lágyrészsarcomáknál

Soft tissue sarcomas are rare, reaching some 1.5% of all malignant tumors. While formerly the surgical management of sarcomas almost exclusively consisted of amputation, in the recent years limb saving surgery has become the first choice of therapy. Negative factors affecting the survival rate are: histologically high-grade tumor, size and localization of the tumor, vascular invasion, extensive tumor necrosis, certain subgroups, local recurrence and oncologically positive surgical margin at the resection. Many modern reconstruction possibilities are essential for the safe limb saving surgery with wide surgical margins, such as bone allograft implantation, tumor endoprostheses reconstruction, vascular grafting and plastic surgery. There should always be an attempt to perform limb saving surgery, however life quality, life expectancy and survival are more important considerations influencing essentially the surgical method of choice. In our follow-up study no significant difference in recurrence rate was found between the group of patients with sarcomas requiring a complex reconstruction procedure and the group of those treated by only resection methods (32% versus 47%)