Analysis of the genes located in rearranged human and chimpanzee chromosomes identified lower divergence than for those in colinear chromosomes

Armengol, Lluís

Bertranpetit, Jaume

Gazave, Elodie

Khaja, Razi

Lopez-Bigas, Núria

Marques-Bonet, Tomàs

Navarro, Arcadi

Rocchi, Mariano

Sànchez-Ruiz, Jesús

Crossref

Springer - Publisher Connector

PubMed Central

Archivio istituzionale della ricerca - Università di Bari

UPF Digital Repository

English

A genome-wide comparison of recent chimpanzee and human segmental duplications. Nature

A high-resolution recombination map of the human genome. Nat Genet

A neutral explanation for the correlation of diversity with recombination rates in humans.

A new study challenges the current belief of a high human male : female mutation ratio. Trends Genet

A scan for positively selected genes in the genomes of humans and chimpanzees. Plos Biol

A: Chromosomal rearrangements and the genomic distribution of gene-expression divergence in humans and chimpanzees. Trends Genet

A: Inversion polymorphisms and nucleotide variability in Drosophila. Genetical Res

Algorithm 209: Gauss.

Altheide TK, et al.: Initial sequence of the chimpanzee genome and comparison with the human genome. Nature

AM: Hybrid speciation accompanied by genomic reorganization in wild sunflowers.

Archidiacano N, et al.: A preliminary comparative analysis of primate segmental duplications shows elevated substitution rates and a great-ape expansion of intrachromosomal duplications. Genome Res

Breakpoint analysis of the pericentric inversion between chimpanzee chromosome 10 and the homologous chromosome 12 in humans. Cytogenet Genome Res

Chimpanzee Segmental Duplications Database

Chromosomal inversions and the reproductive isolation of species.

Chromosomal rearrangements and speciation. Trends Ecol Evol

Chromosome inversions, local adaptation and speciation. Genetics

CI: Comment on &quot;Chromosomal speciation and molecular divergence - accelerated evolution in rearranged chromosomes&quot;.

Coluzzi M: Chromosome speciation: humans, Drosophila, and mosquitoes.

Conery JS: The evolutionary fate and consequences of duplicate genes. Science

Cox DR: Whole-genome patterns of common DNA variation in three human populations. Science

Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels.

EE: A genome-wide survey of structural variation between human and chimpanzee. Genome Res

EE: Shotgun sequence assembly and recent segmental duplications within the human genome. Nature

Eichler EE: Refinement of a chimpanzee pericentric inversion breakpoint to a segmental duplication cluster. Genome Biol

Ellegren H: Sex biases in the mutation rate. Trends Genet

Ensembl 2007. Nucleic Acids Res

Estivill X: Enrichment of segmental duplications in regions of breaks of synteny between the human and mouse genomes suggest their involvement in evolutionary rearrangements. Hum Mol Genet

Estivill X: Murine segmental duplications are hot spots for chromosome and gene evolution. Genomics

Genes on human chromosome 19 show extreme divergence from the mouse orthologs and a high GC content. Nucleic Acids Res

Genetic evidence for complex speciation of humans and chimpanzees. Nature

H: Breakpoint analysis of the pericentric inversion distinguishing human chromosome 4 from the homologous chromosome in the chimpanzee (Pan troglodytes). Hum Mut

H: Molecular characterisation of the pericentric inversion that distinguishes human chromosome 5 from the homologous chimpanzee chromosome. Hum Genet

HF: Analysis of the centromeric regions of the human genome assembly. Trends Genet

How did the human species form? Curr Biol

Human Segmental Duplications Database

Hybrid zones and the genetic architecture of a barrier to gene flow between two sunflower species. Genetics

Independent intrachromosomal recombination events underlie the pericentric inversions of chimpanzee and gorilla chromosomes homologous ZX xx x =− () / μσ σ x σ x σ x pp

Inferring the mode of speciation from genomic data: A study of the great apes. Genetics

Inversion of chromosome-2 that distinguishes between Bornean and Sumatran orangutans. Cytogenet Cell Genet

JK: A map of recent positive selection in the human genome (vol 4, pg 154,

Krauter KS: Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution. Genomics

Lahn BT: Effects of chromosomal rearrangements on human-chimpanzee molecular evolution. Genomics

Li WH: Strong male-driven evolution of DNA sequences in humans and apes. Nature

MAF: Recombination and the divergence of hybridizing species. Genetica

Male-driven evolution. Curr Opin Genet Dev

Molecular characterization of the pericentric inversion of chimpanzee chromosome 11 homologous to human chromosome 9. Genomics

Molecular characterization of the pericentric inversion that causes differences between chimpanzee chromosome 19 and human chromosome 17. Am J Hum Genet

Navarro A: Chromosomal rearrangements are associated with higher rates of molecular evolution in mammals. Gene

NH: Accumulating postzygotic isolation genes in parapatry: A new twist on chromosomal speciation. Evolution

NH: Chromosomal speciation and molecular divergence - accelerated evolution in rearranged chromosomes. Science

NH: Response to comment on &quot;Chromosomal speciation and molecular divergence -accelerated evolution in rearranged chromosomes&quot;.

O: The origin of man - a chromosomal pictorial legacy. Science

Paabo S: Fine-scale recombination patterns differ between chimpanzees and humans. Nat Genet

PAML: a program package for phylogenetic analysis by maximum likelihood.

Positive selection, relaxation, and acceleration in the evolution of the human and chimp genome. Plos Computational Biol

Restricted gene flow at specific parts of the shrew genome in chromosomal hybrids zones. Evolution

Segmental duplication associated with the human-specific inversion of chromosome 18: a further example of the impact of segmental duplications on karyotype and genome evolution in primates. Hum Genet

Sharp PM: Mammalian gene evolution - nucleotidesequence divergence between mouse and rat.

SW: Discovery of human inversion polymorphisms by comparative analysis of human and chimpanzee DNA sequence assemblies. Plos Genet

Testing the chromosomal speciation hypothesis for humans and chimpanzees. Genome Res

The effect of gene flow on the coalescent time in the human-chimpanzee ancestral population. Mol Biol Evol

The Gene Ontology (GO) project in 2006. Nucleic Acids Res

The structure and evolution of centromeric transition regions within the human genome. Nature

WH: Different evolutionary patterns between young duplicate genes in the human genome. Genome Biol

WH: Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees.

On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees

Copyright information:Taken from "On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees"http://genomebiology.com/2007/8/10/R230Genome Biology 2007;8(10):R230-R230.Published online 30 Oct 2007PMCID:PMC2246304. A colinear and an inverted chromosome are presented. The inversion in the rearranged chromosome is highlighted in red. For every chromosome, regions considered in this paper are labeled in black. Regions excluded from the main analysis (telomeres, centromeres and breakpoints (BKP)) are within boxes and labeled in red

Arcadi Navarro (87318)

Elodie Gazave (87317)

Jaume Bertranpetit (72540)

Jesús Sànchez-Ruiz (87316)

Lluís Armengol (40877)

Mariano Rocchi (2047)

Nuria Lopez-Bigas (1759)

Razi Khaja (2036)

Tomàs Marques-Bonet (87315)

FigShare

Abstract overview of the chromosomal regions that were included and excluded from our analysis