DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING HPLC METHOD FOR THE DETERMINATION OF NILOTINIB HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Objective: To develop a rapid, accurate, linear, sensitive and stability indicating RP-HPLC method for the determination of nilotinib in bulk and pharmaceutical dosage forms in the presence of its four related substances.Methods: The RP-HPLC method was developed for the chromatographic separation of nilotinib and its impurities by using waters Xterra RP-18 (150*4.6 mm, 3.5 µm) column with a mobile phase combination of 10 mM ammonium formate with pH-3.5 and acetonitrile in gradient mode. An injection volume of 20 µl. Flow rate was 1.0 ml/min and detection was carried a wavelength of 250 nm. The method was validated as per ICH guidelines.Results: The retention time for nilotinib and its four impurities were found to be 4.37, 7.40, 8.96, 10.21 and 10.87 min respectively. The linear regression analysis data for the calibration plots showed the good linear relationship in the concentration range of 0.04-3.0 ppm for the nilotinib impurities. The % recovery of nilotinib impurities was found to be 96.8-99.4% in the linearity range. The detection limit (LOD) values were about 0.014, 0.016, 0.005 and 0.03 ppm respectively and the quantification limit (LOQ) values were 0.042, 0.048, 0.014 and 0.09 ppm respectively. The % degradation at various stress conditions like acid, alkaline, oxidative, thermal and photolytic stress was found to be 8.92, 18.35,5.63, 0.88 and 3.89 respectively.Conclusion: The RP-HPLC method compatible with LC-MS was developed for the analysis of nilotinib and its four impurities. It was validated as per the ICH guidelines and found to be linear, robust, precise, accurate, sensitive, stability indicating and can be used for routine as well as stability analysis of capsule dosage forms as well as for drug substance

EARTH QUAKE PROGNOSTICATION USING DATA MINING AND CURVE FITTING TECHNIQUES

The title “EARTHQUAKE PROGNOSTICATION” is a Global Earthquake prediction, that is used to predict that an earthquake of a specific magnitude will occur in a particular place at a particular time, we however cannot tell the exact time and date the earthquake is going to occur but we can well predict that an earthquake will affect a given location over a certain number of years. The “Gutenberg Richter power-law distribution of earthquake sizes” implies that the largest events are surrounded by a large number of small events, with this statement we collected the data sets of all the EARTHQUAKES of magnitude ranging from small to big since 1900 to 2010 all over the world. After collecting this data we performed clustering techniques to the datasets available with latitude, longitude and time as parameters, which helped to find similarities between them and discovered patterns using non-linear regression functions that helped to forecast earthquakes. This prediction is based on both the historical seismic catalogue and the structural zoning

Analysis of arrhenius activation energy in electrically conducting casson fluid flow induced due to permeable elongated sheet with chemical reaction and viscous dissipation

The upfront intension of this study is to explore the advances in electrically conducting Casson fluid induced due to a porous elongated surface taking Arrhenius activation energy, viscous dissipation and joule heating into account. Uniform magnetic and electric fields are imposed on the given flow. Variables of similarity are induced to transmute partial differential equations into dimensionless equations and resolved numerically by elegant method bvp4c. To scrutinize the behavior of critical parameters on flow configurations graphs and table are portrayed. From graphical moments, it is analyzed that velocity of the liquid diminish for advanced values of non-Newtonian rheology parameter, magnetic parameter, porous parameter and inertial parameter. This study also reported that activation energy parameter enhances concentration profiles, whereas fitted rate constant shows opposite behavior. Impact of skin friction, Sherwood and Nusselt numbers on the flow configurations for diverse critical parameters are exposed realistically via graphs

Comparison of middle phalanx of the middle finger and cervical vertebrae as skeletal maturity indicators

Objectives: To investigate the relationship between chronological age and the stages of maturation of cervical vertebrae maturation index (CVMI) and the middle phalanx of the middle finger (MP3) and to determine the correlation between CVMI and MP3. Materials and Methods: A cross-sectional study included 100 children (boys - 50, girls - 50) aged 8–14 years based on nonprobability quota sampling. The study included digital radiographs of the MP3 of the right hand and conventional lateral cephalograms. Chronological age was assessed by the date of birth, MP3 maturation by Rajagopal and Kansal's criteria, and CVMI development by Hassel and Farman's method. Statistical Analysis: Spearman's rank-order correlation coefficient was applied to measure the association between stages of MP3 and CVMI. Results: Progressive stages of MP3 and CVMI were seen as chronological age advanced. Girls showed an advanced trend than boys in both MP3 and CVMI stages. MP3 and CVMI stages showed a strong positive correlation (r + 0.836, P < 0.01). Conclusions: MP3 and CVMI both are equally good indicators of skeletal maturity. Assessment of skeletal maturity on lateral cephalogram (CVMI) is advantageous as it avoids the need for an additional radiograph

3rd National Conference on Image Processing, Computing, Communication, Networking and Data Analytics

This volume contains contributed articles presented in the conference NCICCNDA 2018, organized by the Department of Computer Science and Engineering, GSSS Institute of Engineering and Technology for Women, Mysore, Karnataka (India) on 28th April 2018