Bifurcation analysis in an associative memory model

We previously reported the chaos induced by the frustration of interaction in a non-monotonic sequential associative memory model, and showed the chaotic behaviors at absolute zero. We have now analyzed bifurcation in a stochastic system, namely a finite-temperature model of the non-monotonic sequential associative memory model. We derived order-parameter equations from the stochastic microscopic equations. Two-parameter bifurcation diagrams obtained from those equations show the coexistence of attractors, which do not appear at absolute zero, and the disappearance of chaos due to the temperature effect.Comment: 19 page

体育科授業の今日的課題における「集団思考場面」の意義 「主体的・対話的で深い学び」の授業づくり

本年３月に小学校学習指導要領が改訂され、来年度より移行期間を経て2020度より新しい学習指導要領による学校教育が展開されることとなった。育成すべき資質・能力を「知識・技能」「思考力・判断力・表現力等」「学びに向かう力、人間性等」の３つで示し、授業の在り方として「主体的・対話的で深い学び」が提唱されている。このことに基づいて小学校体育科授業の運動領域についてこれからの授業の在り方を検討した。筆者がこれまで実践・研究し提言を続けてきた体育科授業の在り方を国の教育方針及び教育一般の教育方法論、体育科授業論にもとづきながら見直し、授業における児童相互の関わり合いを基盤にしながら、１時間の授業過程のヤマ場として「集団思考場面」を構成することが、知識・技能及び思考力・判断力・表現力等の育成を目標とする新学習指導要領が示すこれからの体育科授業の指導法として意義を持っていることを明らかにした

A Study on In-Service Training for Improving the Professional Development of Teaching Physical Education in Elementary Schools

First this study aims to clarify how elementary school teachers of B Prefecture informed their learning outcomes by in-service training of physical activities to their school colleagues. Secondary this study aims to clarify how in-service training of physical activities at D Elementary School in C City influenced improving school teachers' teaching in physical education. The results are summarized as following points. 1. Elementary school teachers of B Prefecture informed their learning outcomes to their school colleagues through 'in-service training meetings within their schools' or 'their daily job'. 2. D Elementary School Teachers have taught new teaching materials as learning outcomes from ‘in-service training meetings of physical activities'. 3. Teacher X and Teacher Y learned teaching method and subject knowledge of physical education by team teaching experiences with PE coordinators as 'their daily job'. Teacher L learned the way of making unit plan, modification of activities and management of his class from his elder colleague K by dialogues about teaching in physical education as 'their daily job'. 4. It seems that it is important we make mentors' daily supports to mentees between PE coordinators and other school teachers.本研究の一部は,科学研究費補助金(基盤B)課題研究番号24300212の補助によ

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

To discover susceptibility genes of late-onset Alzheimer’s disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic Consortium (ADGC). In Stage 1, we evaluated data for 5,877,918 genotyped and imputed SNPs in Japanese cases (n = 1,008) and controls (n = 1,016). Genome-wide significance was observed with 12 SNPs in the APOE region. Seven SNPs from other distinct regions with p-values ,261025 were genotyped in a second Japanese sample (885 cases, 985 controls), and evidence of association was confirmed for one SORL1 SNP (rs3781834, P=7.3361027 in the combined sample). Subsequent analysis combining results for several SORL1 SNPs in the Japanese, Korean (339 cases, 1,129 controls) and Caucasians (11,840 AD cases, 10,931 controls) revealed genome wide significance with rs11218343 (P=1.7761029) and rs3781834 (P=1.0461028). SNPs in previously established AD loci in Caucasians showed strong evidence of association in Japanese including rs3851179 near PICALM (P=1.7161025) and rs744373 near BIN1 (P = 1.3961024). The associated allele for each of these SNPs was the same as in Caucasians. These data demonstrate for the first time genome-wide significance of LOAD with SORL1 and confirm the role of other known loci for LOAD in Japanese. Our study highlights the importance of examining associations in multiple ethnic populations

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection