726 research outputs found
Strategy for quantum algorithm design assisted by machine learning
We propose a method for quantum algorithm design assisted by machine
learning. The method uses a quantum-classical hybrid simulator, where a
"quantum student" is being taught by a "classical teacher." In other words, in
our method, the learning system is supposed to evolve into a quantum algorithm
for a given problem assisted by classical main-feedback system. Our method is
applicable to design quantum oracle-based algorithm. As a case study, we chose
an oracle decision problem, called a Deutsch-Jozsa problem. We showed by using
Monte-Carlo simulations that our simulator can faithfully learn quantum
algorithm to solve the problem for given oracle. Remarkably, learning time is
proportional to the square root of the total number of parameters instead of
the exponential dependance found in the classical machine learning based
method.Comment: published versio
Quantum-mechanical machinery for rational decision-making in classical guessing game
In quantum game theory, one of the most intriguing and important questions
is, "Is it possible to get quantum advantages without any modification of the
classical game?" The answer to this question so far has largely been negative.
So far, it has usually been thought that a change of the classical game setting
appears to be unavoidable for getting the quantum advantages. However, we give
an affirmative answer here, focusing on the decision-making process (we call
'reasoning') to generate the best strategy, which may occur internally, e.g.,
in the player's brain. To show this, we consider a classical guessing game. We
then define a one-player reasoning problem in the context of the
decision-making theory, where the machinery processes are designed to simulate
classical and quantum reasoning. In such settings, we present a scenario where
a rational player is able to make better use of his/her weak preferences due to
quantum reasoning, without any altering or resetting of the classically defined
game. We also argue in further analysis that the quantum reasoning may make the
player fail, and even make the situation worse, due to any inappropriate
preferences.Comment: 9 pages, 10 figures, The scenario is more improve
Radiculopathy as Delayed Presentations of Retained Spinal Bullet.
Bullet injuries to the spine may cause injury to the anatomical structures with or without neurologic deterioration. Most bullet injuries are acute, resulting from direct injury. However, in rare cases, delayed injury may occur, resulting in claudication. We report a case of intradural bullet at the L3-4 level with radiculopathy in a 30-year-old male. After surgical removal, radicular and claudicating pain were improved significantly, and motor power of the right leg also improved. We report the case of intradural bullet, which resulted in delayed radiculopathy
Tusamitamab Ravtansine in Patients with Advanced Solid Tumors: Phase I Study of Safety, Pharmacokinetics, and Antitumor Activity Using Alternative Dosing Regimens
Advanced solid tumors; Pharmacokinetics; Antitumor activityTumors sòlids avançats; Farmacocinètica; Activitat antitumoralTumores sólidos avanzados; Farmacocinética; Actividad antitumoralPurpose:
Tusamitamab ravtansine is an antibody–drug conjugate that targets carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and delivers a cytotoxic maytansinoid payload. In a phase I dose-escalation study, the maximum tolerated dose (MTD) was 100 mg/m2 every 2 weeks (Q2W). Here we report results for two alternative schedules.
Experimental Design:
Adults ages ≥18 years (range, 34–73) with locally advanced/metastatic solid tumors (N = 43; colon/rectum, 29; stomach, 7; pancreas, 4; other, 3) expressing/likely to express CEACAM5 received intravenous tusamitamab ravtansine 120–170 mg/m2 [loading dose (LD)], then 100 mg/m2 Q2W (Q2W-LD, n = 28), or 120–190 mg/m2 fixed dose [every 3 weeks (Q3W), n = 15]. The primary endpoint was dose-limiting toxicities (DLTs) during cycles 1–2 (Q2W-LD) and cycle 1 (Q3W).
Results:
Reversible DLTs were observed in 2 of 9 patients (grade 2 keratopathy; grade 2 keratitis) with 170 mg/m2 in Q2W-LD and in 2 of 3 patients (grade 2 keratopathy; grade 3 transaminase elevation) with 190 mg/m2 in Q3W. Nineteen (67.9%) patients in Q2W-LD and 13 (86.7%) patients in Q3W experienced treatment-related adverse events (AE); 3 of 43 patients discontinued treatment because of AEs. The most common AEs were asthenia, gastrointestinal complaints, keratopathy, keratitis, and peripheral sensory neuropathy. In this small, heavily pretreated population, no confirmed responses were observed; however, stable disease occurred in 35.7% of patients in Q2W-LD and 40.0% of patients in Q3W.
Conclusions:
Tusamitamab ravtansine had a favorable safety profile with both alternative administration schedules; MTDs were 170 mg/m2 (LD) followed by 100 mg/m2 Q2W, and 170 mg/m2 Q3W as a fixed dose. (NCT02187848).
Significance:
The collective results of this phase I dose-escalation study will inform further studies of tusamitamab ravtansine in patients with solid tumors with CEACAM5 expression, including patients with non–small cell lung cancer.This work was supported by Sanofi. Medical writing support was provided by Blair Jarvis and Elizabeth Strickland of inScience Communications (Philadelphia, PA). This work was performed in accordance with current Good Publication Practice guidelines and funded by Sanofi
Inflammatory Myofibroblastic Tumor of the Kidney Misdiagnosed as Renal Cell Carcinoma
The inflammatory myofibroblastic tumor (IMT), also knowns as inflammatory pseuduotumor, is a soft tissue lesion of unknown etiology. In the urogenital tract, IMT mainly affects the urinary bladder or prostate, but rarely the kidney. It has been considered as a nonneoplastic reactive inflammatory lesion, but nowadays, it is regarded as a neoplasm due to its high recurrence rate and metastasis. We describe a case of a 61-yr-old woman that had originally been misdiagnosed as renal cell carcinoma, which was pathologically revealed to be an IMT
Adsorption of Cd(II) on Waste Calcite Produced by the Carbonation of Flue Gas Desulfurization (FGD) Gypsum
The waste calcite, by-product of the carbonation reaction of flue gas desulfurization (FGD) gypsum, was evaluated as low-cost adsorbent for Cd(II) removal from wastewater. Batch experiments were performed in aqueous solution varying contact time, initial pH of Cd(II) solution, adsorbent dose, and Cd(II) concentration. The sorption rate of Cd(II) on the adsorbent was high during initial 1 h and decreased slowly reaching a plateau after about 12 h. The adsorption kinetics of Cd(II) could be best described by the pseudo-second order model while its isotherm was found to fit with the Langmuir model. The maximum adsorption capacity was 7.99 mg g À1 . It is believed that waste calcite would be an addition to the list of low-cost adsorbents for Cd(II) removal in wastewater treatment
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