Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells

A specific kinetic pattern of c-MYC expression is essential for optimal generation of functional platelets from human induced pluripotent stem cells

Achieving LDL cholesterol target levels <1.81 mmol/L may provide extra cardiovascular protection in patients at high risk: Exploratory analysis of the Standard Versus Intensive Statin Therapy for Patients with Hypercholesterolaemia and Diabetic Retinopathy study

Aims To assess the benefits of intensive statin therapy on reducing cardiovascular (CV) events in patients with type 2 diabetes complicated with hyperlipidaemia and retinopathy in a primary prevention setting in Japan. In the intension-to-treat population, intensive therapy [targeting LDL cholesterol = 2.59 to = 100 to = 2.59 to <3.10 mmol/L in patients with hypercholesterolaemia and diabetic retinopathy

Abstract Fourier Principles for Emotion-based Human Figure Animation

This paper describes the method for modeling human figure locomotions with emotions. Fourier expansions of experimental data of actual human behaviors serve as a basis from which the method can interpolate or extrapolate the human locomotions. This means, for instance, that transition from a walk to a run is smoothly and realistically performed by the method. Moreover an individual&apos;s character or mood, appearing during the human behaviors, is also extracted by the method. For example, the method gets &amp;quot;briskness &amp;quot; from the experimental data for a &amp;quot;normal &amp;quot; walk and a &amp;quot;brisk &amp;quot; walk. Then the &amp;quot;brisk &amp;quot; run is generated by the method, using another Fourier expansion of the measured data of running. The superposition of these human behaviors is shown as an efficient technique for generating rich variations of human locomotions. In addition, step-length, speed, and hip position during the locomotions are also modeled, and then interactively controlled to get a desired animation