Electron acceleration with improved Stochastic Differential Equation method: cutoff shape of electron distribution in test-particle limit

We develop a method of stochastic differential equation to simulate electron acceleration at astrophysical shocks. Our method is based on It\^{o}'s stochastic differential equations coupled with a particle splitting, employing a skew Brownian motion where an asymmetric shock crossing probability is considered. Using this code, we perform simulations of electron acceleration at stationary plane parallel shock with various parameter sets, and studied how the cutoff shape, which is characterized by cutoff shape parameter $a$, changes with the momentum dependence of the diffusion coefficient $\beta$. In the age-limited cases, we reproduce previous results of other authors, $a\approx2\beta$. In the cooling-limited cases, the analytical expectation $a\approx\beta+1$ is roughly reproduced although we recognize deviations to some extent. In the case of escape-limited acceleration, numerical result fits analytical stationary solution well, but deviates from the previous asymptotic analytical formula $a\approx\beta$.Comment: corrected typos, 10 pages, 4 figures, 2 tables, JHEAp in pres

シコク チュウオウブ ササガタニ チイキ ニオケル チチブ ホクタイ ノ チシツ コウゾウ

The Sasagatani fault in central Shikoku was considered to be a tectonic boundary between the Sanbagawa high-P/T metamorphic belt and the Chichibu non-high-P/T belt. Metamorphic minerals of the greenstones around the Sasagatani fault are examined. Alkali amphibole, alkali pyroxene, actinolite, stilpnomelane and pumpellyite are found not only on the north side of the fault, but also on the south side. Strata around the Sasagatani fault have undergone the pumpellyite-actinolite facies metamorphism. Thus, the Sasagatani fault is not an upper boundary fault of the Sanbagawa metamorphic rocks. The Nanokawa thrust occurs in the Jurassic accretionary complexes of the Northern Chichibu Terrain in the Sasagatani Area. The greenstones of the hanging wall of the thrust have undergone the pumpellyite-actinolite facies metamorphism, whereas those of the footwall have undergone the prehnite-pumpellyite facies metamorphism. The Nanokawa thrust is a large overthrust, which has a different metamorphic grade between the hanging wall and footwall. The thrust is probably a southern boundary of the Jurassic accretionary deposits which have undergone the Sanbagawa metamorphism

Study of interleukin-6 in the spread of colorectal cancer: the diagnostic significance of IL-6.

We investigated the diagnostic significance of IL-6 for lymph node metastasis and/or hepatic metastasis from colorectal cancer in 65 patients and evaluated the contributions of 8 factors (IL-6, HGF, IL-1beta, TNF-alpha, TGF-beta1, ELAM-1, ICAM-1, VCAM-1) toward Dukes.s classification of 53 patients. We also examined IL-6 expression in tumor tissue. From the receiver operating characteristic (ROC) curve analysis, an optimal cutoff value of 5.8 pg/ml was determined to classify lymph node and/or hepatic metastasis, and that of 6.3 pg/ml was determined to classify hepatic metastasis. These values indicated sensitivities of 55.0% and 71.4%, and specifi cities of 100% and 88.6%, respectively. IL-6, HGF, and ELAM-1 were very useful for distinguishing among Dukes.s A/B group, C group, and D group. In all cases with high IL-6 values (more than 25.0 pg/ml), immunohistochemical staining was positive for IL-6 in the cytoplasm of cancer cells. IL-6 is strongly suspected to be involved in lymph node and/or hepatic metastasis by promoting it through HGF, and serum IL-6 value (pg/ml) would be useful diagnostically to estimate whether or not there is a high risk of lymph node and/or hepatic metastasis

Gastric linitis plastica with autoimmune pancreatitis diagnosed by an endoscopic ultrasonography-guided fine-needle biopsy: A case report

BACKGROUND Gastric linitis plastica (GLP) is a subset of gastric cancer with a poor prognosis. It is difficult to obtain a definitive diagnosis by endoscopic mucosal biopsies, and the usefulness of an endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) for GLP has been recently reported. Meanwhile, autoimmune diseases are occasionally known to coexist with malignant tumors as paraneoplastic syndrome. We herein report the usefulness of an EUS-FNB for detecting GLP and the possibility of paraneoplastic syndrome coexisting with GLP. CASE SUMMARY An 81-year-old man was admitted to our hospital for a 1-mo history of epigastric pain that increased after eating. His laboratory data revealed high levels of serum carbohydrate antigen 19-9 and immunoglobulin-G4. Endoscopic examinations showed giant gastric folds and reddish mucosa; however, no epithelial changes were observed. The gastric lumen was not distensible by air inflation, suggesting GLP. Computed tomography showed the thickened gastric wall, the diffuse enlargement of the pancreas, and the peripancreatic rim, which suggested autoimmune pancreatitis (AIP) coexisting with GLP. Because the pathological findings of the endoscopic biopsy showed no malignancy, he underwent an EUS-FNB and was diagnosed with GLP. He received chemotherapy for unresectable gastric cancer due to peritoneal metastasis, after which both the gastric wall thickening and diffuse enlargement of the pancreas were improved. CONCLUSION An EUS-FNB for GLP with a negative endoscopic biopsy is useful, and AIP may develop as a paraneoplastic syndrome

Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a crucial role in protection of cells from electrophile-induced toxicity through up-regulating phase II detoxifying enzymes and phase III transporters. We previously reported that oxidative stress induces up-regulation of interleukin-11 (IL-11), a member of the IL-6 family that ameliorates acetaminophen-induced liver toxicity. However, a role for IL-11 in protection of cells from electrophile-induced toxicity remains unclear. Here we show that an environmental electrophile, 1,2-naphthoquinone (1,2-NQ), but not 15d-prostaglandin J2 (PGJ2) or tert-butylhydroxyquinone (tBHQ), induced IL-11 production. Consistent with a crucial role for prolonged ERK activation in H2O2-induced IL-11 production, 1,2-NQ, but not 15d-PGJ2 or tBHQ, elicited prolonged ERK activation. Conversely, inhibition of the ERK pathway by a MEK inhibitor completely blocked 1,2-NQ-induced IL-11 production at both protein and mRNA levels, further substantiating an intimate cross-talk between ERK activation and 1,2-NQ-induced IL-11 production. Promoter analysis of the Il11 gene revealed that two AP-1 sites were essential for 1,2-NQ-induced promoter activities. Among various members of the AP-1 family, Fra-1 was up-regulated by 1,2-NQ, and its up-regulation was blocked by a MEK inhibitor. Although NRF2 was not required for H2O2-induced IL11 up-regulation, NRF2 was essential for 1,2-NQ-induced IL11 up-regulation by increasing Fra-1 proteins possibly through promoting mRNA translation of FOSL1. Finally, intraperitoneal administration of 1,2-NQ induced body weight loss in wild-type mice, which was further exacerbated in Il11ra1−/− mice compared with Il11ra1+/− mice. Together, both Fra-1 and NRF2 play crucial roles in IL-11 production that protects cells from 1,2-NQ intestinal toxicity

High Concentrations of Sulfur Dioxide and Sulfate Particles Observed in Suzu City, the Noto Peninsula in Late July 2012 : On the Influence of the Smoke of Sakurajima

Measurements of SO2 and sulfate aerosol concentrations in the atmosphere were performed in Suzu City, the Noto Peninsula, Ishikawa Prefecture in the summer of 2012. High concentrations of SO2 and sulfate aerosols in PM25 were observed in late July when CO and O3 concentrations did not increased. The high SO, and sulfate particles may not be due to anthropogenic air pollution. According to the atmospheric pressure pattern in summer and the results of trajectory analyses, the air mass over the Noto Peninsula was transported from the southern part of Kyushu. The large eruption of Sakurajima occurred on 24 July in 2012, and the fumes were transported to the Hokuriku district. Recently, the volcanic eruptions of Sakurajima have increased in activity and may highly affect the air environment, such as PM25, over Japan