Submillimeter detection of the Sunyaev -- Zel'dovich effect toward the most luminous X-ray cluster at z=0.45

We report on the detection of the Sunyaev -- Zel'dovich (SZ) signals toward the most luminous X-ray cluster RXJ1347-1145 at Nobeyama Radio Observatory (21 and 43 GHz) and at James Clerk Maxwell Telescope (350 GHz). In particular the latter is the first successful detection of the SZ temperature increment in the submillimeter band which resolved the profile of a cluster of galaxies. Both the observed spectral dependence and the radial profile of the SZ signals are fully consistent with those expected from the X-ray observation of the cluster. The combined analysis of 21GHz and 350GHz data reproduces the temperature and core-radius of the cluster determined with the ROSAT and ASCA satellites when we adopt the slope of the density profile from the X-ray observations. Therefore our present data provide the strongest and most convincing case for the detection of the submillimeter SZ signal from the cluster, as well as in the Rayleigh -- Jeans regime. We also discuss briefly the cosmological implications of the present results.Comment: 11 pages, The Astrophysical Journal (Letters), in pres

Cool core disturbed: Observational evidence for coexistence of sub-sonic sloshing gas and stripped shock-heated gas around the core of RX J1347.5-1145

RXJ1347.5-1145 (z = 0.451) is one of the most luminous X-ray galaxy clusters, which hosts a prominent cool core and exhibits a signature of a major merger. We present the first direct observational evidence for sub-sonic nature of sloshing motion of the cool core. We find that a residual X-ray image from the Chandra X-ray Observatory after removing the global emission shows a clear dipolar pattern characteristic of gas sloshing, whereas we find no significant residual in the Sunyaev-Zel'dovich effect (SZE) image from the Atacama Large Millimeter/submillimeter Array (ALMA). We estimate the equation of state of perturbations in the gas from the X-ray and SZE residual images. The inferred velocity is 420 +310 -420 km s-1, which is much lower than the adiabatic sound speed of the intracluster medium in the core. We thus conclude that the perturbation is nearly isobaric, and gas sloshing motion is consistent with being in pressure equilibrium. Next, we report evidence for gas stripping of an infalling subcluster, which likely shock-heats gas to high temperature well in excess of 20 keV. Using mass distribution inferred from strong lensing images of the Hubble Space Telescope (HST), we find that the mass peak is located away from the peak position of stripped gas with statistical significance of > 5{\sigma}. Unlike for the gas sloshing, the velocity inferred from the equation of state of the excess hot gas is comparable to the adiabatic sound speed expected for the 20 keV intracluster medium. All of the results support that the southeast substructure is created by a merger. On the other hand, the positional offset between the mass and the gas limits the self-interaction cross section of dark matter to be less than 3.7 h-1 cm2 g-1 (95% CL).Comment: 18 pages, 10 figures, accepted for publication in Ap

Low Surface Potential with Glycoconjugates Determines Insect Cell Adhesion at Room Temperature

Cell-coupled field-effect transistor (FET) biosensors have attracted considerable attention because of their high sensitivity to biomolecules. The use of insect cells (Sf21) as a core sensor element is advantageous due to their stable adhesion to sensors at room temperature. Although visualization of the insect cell-substrate interface leads to logical amplification of signals, the spatiotemporal processes at the interfaces have not yet been elucidated. We quantitatively monitored the adhesion dynamics of Sf21 using interference reflection microscopy (IRM). Specific adhesion signatures with ring-like patches along the cellular periphery were detected. A combination of zeta potential measurements and lectin staining identified specific glycoconjugates with low electrostatic potentials. The ring-like structures were disrupted after cholesterol depletion, suggesting a raft domain along the cell periphery. Our results indicate dynamic and asymmetric cell adhesion is due to low electrostatic repulsion with fluidic sugar rafts. We envision the logical design of cell-sensor interfaces with an electrical model that accounts for actual adhesion interfaces.Matsuzaki T., Terutsuki D., Sato S., et al. Low Surface Potential with Glycoconjugates Determines Insect Cell Adhesion at Room Temperature. Journal of Physical Chemistry Letters 2022 13(40), 9494-9500. DOI: 10.1021/acs.jpclett.2c01673. Copyright © 2022 American Chemical Society

Larval pufferfish protected by maternal tetrodotoxin

Marine pufferfish contain tetrodotoxin (TTX), an extremely potent neurotoxin. All species of the genus Takifugu accumulate TTX in the liver and ovaries, although the tissue(s) in which it is localized can differ among species. TTX is the major defense strategy the pufferfish appears to use against predators. TTX is also used as a male-attracting pheromone during spawning. Here we demonstrate an additional (and unexpected) use of maternal TTX in the early larval stages of the Takifugu pufferfish. Predation experiments demonstrated that juveniles of all the species of fish used as predators ingested pufferfish larvae, but spat them out promptly. Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) analysis revealed that the pufferfish larvae contain a small quantity of TTX, which is not enough to be lethal to the predators. Immunohistochemical analysis with anti-TTX monoclonal antibody revealed that the TTX is primarily localized in the body surface of the larvae as a layer of protection. Our study showed the female parent of the Takifugu pufferfish vertically transfers TTX to the larvae through its accumulation in the ovaries, and subsequent localization on the body surface of the larvae

Clinical effective use of Conquest Pro 12 Sharpened Tip for chronic total occlusion intervention: A series of three case reports

Abstract A new chronic total occlusion (CTO) guidewire, Conquest Pro 12 Sharpened Tip (CP12ST), has a stronger penetration force than the original CP12 and a deflection effect that it does not have. The CP12ST enables us to advance into hard plaque that has not ever penetrated, which might change CTO treatment as shown in three cases

Remorse‐related suicide attempts among young mothers after COVID‐19 infection

Abstract Background In Japan, there is a tendency to view COVID‐19 infection as one's own responsibility, which may result in more feelings of guilt than in other countries. During the COVID‐19 pandemic, the curfew imposed by COVID‐19 restricted social behavior and increased anxiety and loneliness, which may have increased the risk of suicide among young women, especially mothers who were highly stressed regarding COVID‐19 infection in their children. Case Presentation This is a case report of two Japanese mothers who developed feelings of guilt following infection with COVID‐19, leading to suicide attempts. They feared stigma or denial due to the infection, which they were unable to explain to others, leading to a heightened sense of self‐blame and suicide attempts. In addition, Japanese women have a heavy burden of housework, despite their dual roles at home and at work; the pandemic's behavioral restrictions led to increased time at home and stress. These women were also more affected by the economic crisis in the early stages of the pandemic than men. Relatedly, neuropsychiatric symptoms that persisted after recovering from COVID‐19, such as depression, anxiety, fatigue, and pain, namely postacute COVID‐19 syndrome or long COVID, may have precipitated the suicidal ideation in these cases. Moreover, the complication of bipolar disorder by COVID‐19 could have led to suicide attempts caused by infection‐related neuropsychiatric symptoms and the exacerbation of the bipolar disorder by restrictions imposed during the pandemic. Conclusion Suicide prevention measures need to be taken more seriously among mothers during or after the COVID‐19 pandemic