"Hazardous zones" within "security perimeter": comparative study on the material of folkloric discourse

The article considers the concept of "house" as a core element of "security perimeter" (the term by A. Leroy-Gourhan) on the material of English, Russian and Scottish ballad

Tsar and his people: power and society in Moscow state during the second half of the 16th century

The article raises the issue about the nature of the relationship between the supreme power and society of the early Russian state. The authors of the article show that this unwritten contract, which was well understood by both parties, who participated in it, functioned well in Russia during the 16th - 17th centuries, and its existence refutes convincingly the Herberstein's passage, who failed to understand the Russian political realities of the early Modern Ag

The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension

Metabolic pathways enriched with genes differentially expressed in ISIAH and WAG renal medulla. (XLS 41 kb

THE CURRENT SITUATION ON ANTHRAX IN RUSSIA AND IN THE WORLD. MAIN TRENDS AND FEATURES

The current situation on anthrax is characterized as unstable. Instability is associated with recurring epizootic outbreaks complicated by human anthrax cases, as people contract infection mainly through contact with sick animals, their carcasses or animal products. Mentioned are new aerosol and parenteral ways of anthrax contracting. Parenteral use of contaminated heroin led to emergence of new clinical form of anthrax – injectional. Conception on anthrax agent evolution is replenished by data on pathogenic bacilli strains, that occupy an intermediate position between B. anthracis and B. cereus. Ecology of anthrax microbe is considered in view of its interaction with bacteriophages, rhizosphere and soil microflora. Research related to the environmental characteristics of habitat niches and genotypes of B. anthracis, explaining the geographical distribution of areas with a high risk of disease, may allow to optimize the program of animals immunization, which is the most effective measure for the prevention of anthrax

Multiplex Real Time PCR Test-System for the Detection of Anthrax Causative Agent

Designed is a multiplex PCR-RT test-system for the detection of anthrax causative agent using hybridization fluorescence detection – “ Bacillus anthracis multiplex 3 FRT”. This test-system contains enclosed reference sample for carrying out control procedure in the phase of DNA purification, primers and probes to specific DNA target sequences of the two plasmid and one chromosomal B. anthracis genes. It allows for identification B. anthracis strains both possessing plasmids (one or two) and plasmidless, revealing their genetic pathogenicity potential, and for differentiation between anthrax agent strains and closely related saprophytes belonging to Bacillus species

Application of <i>Bacillus anthracis</i> Molecular Typing Methods by the Reference Center for the Anthrax Agent Monitoring

Presented are the results of B. anthracis molecular typing of in the scope of work of the Reference center for the anthrax agent monitoring. Summarized is the experience of genotyping application in epidemiological investigation of anthrax outbreaks. MLVA-genotyping (8-25 VNTR-loci analysis) of B. anthracis strains, isolated in Russia and in neighboring regions is shown to provide the correct comparison of genotypes with the data of the global MLVA-data bank. The major tasks of reference center for the development of approaches to B. anthracis genotyping are identified. These approaches include research of additional genotyping methods such as SNP analysis, SNR analysis with assessment of the described loci variability and identification of new polymorphic regions

Analysis of occurrence rate of csf shunt systems failure variants and development of patient examination algorithm suspected of shunt failure

964 cases of surgical interventions for the installation of CSF shunt systems and 192 cases of revising previously installed shunts for the period from 2015 to 2019 were analyzed. Options for the insolvency of CSF shunt systems, their possible causes of occurrence were identified and classified, and the algorithm for examining the patient and choosing a revision intervention was presentedПроанализированы 964 случая выполнения оперативных вмешательств по поводу установки ликвородренирующих систем и 192 случая ревизии ранее установленных шунтов за период с 2015 по 2019 г. Выявлены и классифицированы варианты несостоятельностей ликворошунтирующих систем, их возможные причины возникновения, и представлен алгоритм обследования пациента и выбора ревизионного вмешательства

Prediction of overall survival of patients with brain metastasis

The aim of the study – to identify factors that affect the life expectancy of patients with brain metastases.Цель исследования - выявить факторы, влияющие на продолжительность жизни пациентов с метастазами в головной мозг

Application of Basophil Activation Test with Anthraxin for Laboratory ( <I>in vitro</I>) Diagnostics of Anthrax

Demonstrated is the possibility to use in vitro basophil activation test with anthraxin, with registration of the results by means of flow cytometry, for anthrax diagnostics. This approach seems promising as it provides quantitative assessment of sensitization of the organism and does not cause its additional allergization. The duration of the analysis is 1h. The test is suggested for application, as an express one, for early and retrospective laboratory diagnostics of anthrax, estimation of post-vaccinal immunity