Mountain Militarism and Urban Modernity: Balkanism, Identity and the Discourse of Urban–Rural Cleavages during the Bosnian War (SWP 56)

Recent years have witnessed a growth in research addressing the ways in which policymakers, academics and the media characterized the Bosnian war of the 1990s using a variety of problematic discursive frames. Relatively few scholars have explored how the conflict was often portrayed as a battle between innocent urban centres and an antagonistic countryside. This thesis* uses a discourse analysis of Western and Bosnian textual material to argue that perceptions of the Bosnian war have been characterized by a discourse that attributes the violence to cleavages between urban Bosnians and their rural counterparts. Moreover, I engage post-colonial theory to demonstrate that this discourse of urban–rural cleavages, in which Western and Bosnian urban self-identity was constructed in opposition to the supposed atavism of the Bosnian countryside, is an advancement of Bakic-Hayden’s concept of “nesting Orientalisms.” My findings problematize a common representation of the conflict, expand the concept of nesting Orientalism and help us to understand why urban participation in the ideologies and violence of the Bosnian conflict has often gone unexamined. (*This working paper is a slight revision of the author’s MA thesis, which was defended at Simon Fraser University on January 11, 2017.

The tumour microenvironment links complement system dysregulation and hypoxic signalling.

The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated processes such as increased proliferation, angiogenesis and migration. Several cellular members of the tumour microenvironment express and/or produce complement proteins locally, including tumour cells. Dysregulation of the complement system has been reported in numerous tumours and increased expression of complement activation fragments in cancer patient specimens correlates with poor patient prognosis. Importantly, genetic or pharmacological targeting of complement has been shown to reduce tumour growth in several cancer preclinical models, suggesting that complement could be an attractive therapeutic target. Hypoxia (low oxygen) is frequently found in solid tumours and has a profound biological impact on cellular and non-cellular components of the tumour microenvironment. In this review, we focus on hypoxia since this is a prevailing feature of the tumour microenvironment that, like increased complement, is typically associated with poor prognosis. Furthermore, interesting links between hypoxia and complement have been recently proposed but never collectively reviewed. Here, we explore how hypoxia alters regulation of complement proteins in different cellular components of the tumour microenvironment, as well as the downstream biological consequences of this regulation

Evaluating Reproductive Success and Changes in Genetic Diversity of Grizzly Bears in Northwestern Montana

Current range expansions of large terrestrial carnivores are occurring following anthropogenically-induced range contraction. Contractions are often incomplete, leaving small remnant groups in refugia throughout the former range. We know little about underlying eco-evolutionary processes that influence how remnant groups are affected during range expansion. We used data from a spatially-explicit, long-term genetic sampling effort of grizzly bears (Ursus arctos) in the Northern Continental Divide Ecosystem (NCDE) to identify the processes underlying spatial patterns of genetic diversity. We conducted parentage analysis to evaluate how reproductive success and migration contribute to spatio-temporal patterns of genetic diversity in remnant groups of grizzly bears existing in the southwestern (SW), southeastern (SE), and east-central (EC) regions of the NCDE. Highly skewed reproductive success and local inbreeding caused distinct signatures in remnants that eroded rapidly (~1 generation) during population expansion and migration into the regions. Our results highlight that individual-level genetic and reproductive dynamics play critical roles during genetic assimilation, and show that patterns of genetic distinctiveness on the leading edge of an expansion may result from historical demographic patterns that are highly ephemeral

The Australian Orthopaedic Association National Joint Replacement Registry

The document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included.In the financial year ending June 2002, 26 689 hip replacements and 26089 knee replacements (total, 52778) were performed in Australia. Hip and knee replacement procedures have increased between 5%-10% each year for the past 10 years, with a combined increase in hip and knee replacement of 13.4% in the past year. The revision rate for hip replacement surgery in Australia is unknown but is estimated to be 20%-24%; the revision rate for hip replacement surgery in Sweden is 7%. Although data collection for the Registry is voluntary, it has 100% compliance from hospitals undertaking joint-replacement surgery.Stephen E Graves, David Davidson, Lisa Ingerson, Philip Ryan, Elizabeth C Griffith, Brian F J McDermott, Heather J McElroy and Nicole L Prat

Moral judgement development during medical student clinical training

Background: Whereas experience and cognitive maturity drives moral judgement development in most young adults, medical students show slowing, regression, or segmentation in moral development during their clinical years of training. The aim of this study was to explore the moral development of medical students during clinical training. Methods: A cross-sectional sample of medical students from three clinical years of training were interviewed in groups or individually at an Australian medical school in 2018. Thematic analysis identified three themes which were then mapped against the stages and dimensions of Self-authorship Theory. Results: Thirty five medical students from years 3–5 participated in 11 interviews and 6 focus groups. Students shared the impacts of their clinical experiences as they identified with their seniors and increasingly understood the clinical context. Their accounts revealed themes of early confusion followed by defensiveness characterised by desensitization and justification. As students approached graduation, some were planning how they would make moral choices in their future practice. These themes were mapped to the stages of self-authorship: External Formulas, Crossroads and Self-authorship. Conclusions: Medical students recognise, reconcile and understand moral decisions within clinical settings to successfully reach or approach self-authorship. Curriculum and support during clinical training should match and support this progress

Response to Mild Cognitive Impairment: How to Run a Cognitive Rehabilitation Class

Many older adults experience cognitive impairment that negatively affects their quality of life. Previous research has shown that the onset of dementia can be delayed by participation in cognitive stimulation programs that are designed to counteract these effects. Cognitive stimulation can even lead to improvements in cognition (e.g., attention, encoding, and working memory capacity). This presentation will describe how these classes are run and the benefits to one’s cognitive wellness. We will demonstrate a number of cognitively stimulating activities, as well as several activities recently developed and tested by the Cognitive Rehabilitation Team at Western Oregon University

Comparing the Cognitive Screening Tools MMSE and SLUMS

We compared the MMSE and SLUMS cognitive tests. The MMSE is the most widely used neuropsychology tests and dementia screening tools. The SLUMS is a newer and possibly better screening tool. Many practitioners have used MMSE scores to recommend treatment and they are unsure how these scores compare to SLUMS scores. Older adult participants in a variety of living environments were given both tests. Significant differences between test scores such that the MMSE scores were higher than SLUMS were found. The difference between MMSE and SLUMS scores as a function of educational attainment and other demographic variables will be discussed

Detecting and confirming residual hotspots of lymphatic filariasis transmission in American Samoa 8 years after stopping Mass Drug Administration

The Global Programme to Eliminate Lymphatic Filariasis (LF) aims to eliminate the disease as a public health problem by 2020 by conducting mass drug administrations (MDA) and controlling morbidity. Once elimination targets have been reached, surveillance is critical for ensuring that programmatic gains are sustained and challenges include timely identification of residual areas of transmission. WHO guidelines encourage cost-efficient surveillance, such as integration with other population-based surveys. In American Samoa, where LF is caused by Wuchereria bancrofti, and Aedes polynesiensis is the main vector, the LF elimination program has made significant progress. Seven rounds of MDA (albendazole and diethycarbamazine) were completed from 2000 to 2006, and Transmission Assessment Surveys were passed in 2010/2011 and 2015. However, a seroprevalence study using an adult serum bank collected in 2010 detected two potential residual foci of transmission, with Og4C3 antigen (Ag) prevalence of 30.8% and 15.6%. We conducted a follow up study in 2014 to verify if transmission was truly occurring by comparing seroprevalence between residents of suspected hotspots and residents of other villages. In adults from non-hotspot villages (N=602), seroprevalence of Ag (ICT or Og4C3), Bm14 antibody (Ab) and Wb 123 Ab were 1.2% (95% CI 0.6-2.6%), 9.6% (95% CI 7.5-12.3%) and 10.5% (95% CI 7.6-14.3%), respectively. Comparatively, adult residents of Fagali'i (N=38) had significantly higher seroprevalence of Ag (26.9%, 95% CI 17.3-39.4%), Bm14 Ab (43.4%, 95% CI 32.4-55.0%), and Wb123 Ab 55.2% (95% CI 39.6-69.8%). Adult residents of Ili'ili/Vaitogi/Futiga (N=113) also had higher prevalence of Ag and Ab, but differences were not statistically significant. The presence of transmission was demonstrated by 1.1% Ag prevalence (95% CI 0.2% to 3.1%) in 283 children aged 7-13 years who lived in one of the suspected hotspost, including a 9 year old child. Our results provide field evidence that integrating LF surveillance with other surveys is effective and feasible for identifying potential hostpots, and conducting surveillance at worksites provides an efficient method of sampling large populations of adults