291 research outputs found
Comparison of flow resistance relations for debris flows using a one-dimensional finite element simulation model
International audienceThis paper describes a one-dimensional finite element code for debris flows developed to model the flow within a steep channel and the stopping conditions on the fan. The code allows the systematic comparison of a wide variety of previously proposed one-phase flow resistance laws using the same finite element solution method. The one-dimensional depth-averaged equations of motion and the numerical model are explained. The model and implementation of the flow resistance relations was validated using published analytical results for the dam break case. Reasonable agreement for the front velocities and stopping location for a debris-flow event in the Kamikamihori torrent in Japan can be achieved with turbulent flow resistance relations including "stop" terms which allow the flow to come to rest on a gently sloping surface. While it is possible to match the overall bulk flow behavior using relatively simple flow resistance relations, they must be calibrated. A sensitivity analysis showed that the shape of the upstream input hydrograph does not much affect the flow conditions in the lower part of the flow path, whereas the event volume is much more important
Triangulations Admit Dominating Sets of Size
We show that every planar triangulation on vertices has a dominating
set of size . This approaches the bound conjectured by
Matheson and Tarjan [MT'96], and improves significantly on the previous best
bound of by \v{S}pacapan [\v{S}'20].
From our proof it follows that every 3-connected -vertex
near-triangulation (except for 3 sporadic examples) has a dominating set of
size . On the other hand, for 3-connected near-triangulations, we show a
lower bound of , demonstrating that the conjecture by
Matheson and Tarjan [MT'96] cannot be strengthened to 3-connected
near-triangulations.
Our proof uses a penalty function that, aside from the number of vertices,
penalises vertices of degree 2 and specific constellations of neighbours of
degree 3 along the boundary of the outer face. To facilitate induction, we not
only consider near-triangulations, but a wider class of graphs (skeletal
triangulations), allowing us to delete vertices more freely. Our main technical
contribution is a set of attachments, that are small graphs we inductively
attach to our graph, in order both to remember whether existing vertices are
already dominated, and that serve as a tool in a divide and conquer approach.
Along with a well-chosen potential function, we thus both remove and add
vertices during the induction proof.
We complement our proof with a constructive algorithm that returns a
dominating set of size . Our algorithm has a quadratic running time
Quantifying dimensions of physical behavior in chronic pain conditions.
BACKGROUND: Chronic pain, defined as persistent or recurrent pain lasting longer than 3 months, is a frequent condition affecting an important percent of population worldwide. Pain chronicity can be caused by many different factors and is a frequent component of many neurological disorders. An important aspect for clinical assessment and design of effective treatment and/or rehabilitation strategies is to better understand the impact of pain on domains of functioning in everyday life. The aim of this study was to identify the objectively quantifiable features of physical functioning in daily life and to evaluate their effectiveness to differentiate behavior among subjects with different pain conditions.
METHOD: Body worn sensors were used to record movement data during five consecutive days in 92 subjects. Sensor data were processed to characterize the physical behavior in terms of type, intensity, duration and temporal pattern of activities, postures and movements performed by subjects in daily life. Metrics quantifying these features were subsequently used to devise composite scores using a factor analysis approach. The severity of clinical condition was assessed using a rating of usual pain intensity on a 10-cm visual analog scale. The relationship between pain intensity and the estimated metrics/composite scores was assessed using multiple regression and discriminant analysis.
RESULTS: According to the factor analysis solution, two composite scores were identified, one integrating the metrics quantifying the amount and duration of activity periods, and the other the metrics quantifying complexity of temporal patterns, i.e., the diversity of body movements and activities, and the manner in which they are organized throughout time. All estimated metrics and composite scores were significantly different between groups of subjects with clinically different pain levels. Moreover, analysis revealed that pain intensity seemed to have a more significant impact on the overall physical behavior, as it was quantified by a global composite score, whereas the type of chronic pain appeared to influence mostly the complexity of the temporal pattern.
CONCLUSION: The methodology described could be informative for the design of objective outcome measures in chronic pain management/rehabilitation programs
Elastic behaviour of the carotid artery in intact spontaneously hypertensive rats
Intact spontaneously hypertensive rats (SHR) were studied to assess the effect of prolonged antihypertensive treatment on the elastic behaviour of the external carotid artery. Thirty-week-old SHR received the ACE inhibitor captopril, the ateriolar dilator hydralazine or their vehicle for 6 weeks. These rats were compared to normotensive, vehicle treated WKY rats. The internal diameter of the carotid artery was measured continuously in halothane-anaesthetized rats using an echo-tracking device, and intra-arterial pressure was also monitored continuously, on the controlateral side. Captopril- and hydralazinetreated SHR as well as normotensive controls had similar blood pressure values. No significant shift in the distensibility-pressure curves was observed among vehicle-treated SHR and WKY rats or the SHR which had received captopril or hydralazine. Histological examination of the carotid artery fixed ex vivo with paraformaldehyde showed a significant increase in cross-sectional area in vehicle-treated SHR as compared to their normotensive counterparts. These results therefore suggest that the elastic behaviour of elastic arteries is not necessarily altered by the structural changes developing in response to hypertensio
Cell-Associated HIV-1 RNA in Blood as Indicator of Virus Load in Lymph Nodes
We have developed sensitive assays for viremia and cell-associated human immunodeficiency virus type 1 (HIV-1) RNA and DNA to assess the predictive value of virological parameters determined in blood for virus load in lymph nodes (LNs). Eighteen patients were included; 13 received stavudine/didanosine/hydroxyurea and 5 stavudine/didanosine, and all had viremia 3 months. At the time of LN biopsy (median, 10 months), the median viremia was 2.09 log copies/mL (range, <0.70-3.34). Cell-associated HIV-1 RNA and DNA were detectable in blood and LNs of all patients. The median cell-associated RNA and DNA were 2.16 log copies/106 cells and 2.60 log copies/106 cells in blood versus 4.31 log RNA copies/106 cells and 3.26 log DNA copies/106 cells in LNs. Regression analysis shows that, in treated patients with sustained low viremia, cell-associated RNA and DNA in blood are better predictors of virus load in LNs than viremi
Impact of Treatment with Human Immunodeficiency Virus (HIV) Protease Inhibitors on Hepatitis C Viremia in Patients Coinfected with HIV
The impact of human immunodeficiency virus (HIV) protease inhibitors on hepatitis C (HCV) viremia was assessed in 19 patients infected with both HIV and HCV. HIV and HCV RNA levels were measured before and during treatment with protease inhibitors. before treatment, mean levels of HCV RNA were 5.3 log for HCV RNA and 5.0 log for HIV RNA. CD4 lymphocyte counts were 63/mm3. after 6 weeks of treatment, a mean reduction of 2.1 log10 in HIV RNA (P < .001) and a mean (±SE) increase of 73 (±21) CD4 and 296 (±70) CD8 cells were observed (P < .05). In contrast, both HCV viremia (+0.4 log ± 0.1) and alanine aminotransferase increased (P < .04). HCV RNA levels returned to baseline after 17 and 32 weeks of treatment. Thus, potent anti-HIV regimens with protease inhibitors may temporarily worsen HCV status despite improvement of HIV parameter
Effect of starvation or treatment with corticosterone on the amount of easily releasable myofilaments in rat skeletal muscles
Activation of the multicatalytic proteinase from rat skeletal muscle by fatty acids or sodium dodecyl sulphate
Purification and characterization of a multicatalytic high-molecular-mass proteinase from rat skeletal muscle
Activity of a gelsolin-like actin modulator in rat skeletal muscle under protein catabolic conditions
- …