Mycobacterium avium-intracellulare infection presenting as a testicular mass in an immunocompromised patient: a case report

Isolated mycobacterial infections of the genital tract are extremely rare. Here we present a 63-year-old gentleman who developed an isolated non-tuberculous mycobacterial mass in the inferior pole of his right testis, secondary to immunocompromise related to multiple autoimmune and haematological conditions and their treatments

Comparison of Two Online Interventions to Cope with Spinal Cord Injury: A Pilot Study

Spinal cord injury (SCI) is a disability and life experience that may suddenly, drastically, and forever change a person’s life. While psychosocial interventions and support services are typically integrated within the acute rehabilitation process, there is limited research on psychosocial interventions and support services after individuals have been discharged from the hospital and are living in their communities again. To address this void and important need, two interventions were administrated through an online website to people who had lived with a spinal cord injury (SCI) for at least one year. Results found that both Enright’s (2001) forgiveness intervention and Kennedy and Duff’s (2001) coping intervention were effective at reducing depression, anxiety, and anger from pre-test to post-test, and pre-test to follow-up, both separately and in comparison to one another. Findings from this study are discussed, followed by possible limitations

Forgiveness and psychosocial reactions to disability: a pilot study to examine change in persons with spinal cord injury

Spinal cord injuries (SCI) are among the most traumatic onset of disabilities to date. Due to the nature of spinal cord injury and how it affects the person’s life and psychosocial adjustment, there are a multitude of feelings, changes, persons, situations, and transgressions that need to be resolved and forgiven. In an effort to help persons with SCI do that, two interventions - Enright’s Forgiveness is a Choice intervention and Kennedy and Duff’s (2001) Coping Effectively with Spinal Cord Injury training – were facilitated on-line as part of a self-study treatment format among persons with spinal cord injury. The interventions were examined to determine their ability to aid in the increase of forgiveness and changes in psychosocial reactions to disability. Findings from this study found that both interventions are applicable and helpful in assisting persons with SCI in forgiving and experiencing changes in psychosocial reactions to disability, but differences were found in long-term change

Learning to adapt health and safety initiatives from mega projects: an Olympic case study

Finding new ways to improve health and safety management in construction continues to generate much interest. Despite a reduction in deaths, injuries and ill health in recent years, UK construction still has high rates of fatal and major injuries compared to other industries. One of the key concerns is the difficulty of organisational learning in construction manifested as reactive responses to health and safety issues. The Olympic Delivery Authority launched a learning legacy programme in conjunction with industry, government and academia to capture important lessons learnt in a number of areas, including health and safety. Communication has long been considered an important factor in the implementation of health and safety initiatives. Previous research has typically focused on programmes run by single organisations. The London 2012 Olympic Park construction project offered a unique opportunity to investigate the impact of safety initiatives and communication across a range of organisations working side by side. It also offered an exciting opportunity to track health and safety messages as they are communicated to the workforce. The main aim of this research project was to evaluate the range of health and safety initiatives used at the Olympic Park in terms of messages communicated to workers, workers’ awareness, attitude and behaviour, and the transfer of knowledge within and outside the Park. A semistructured inventory was used to survey the workforce (managers, supervisors and workers) using interviews and focus groups on seven Park sites. A follow-up survey was conducted after three months, at which time interviews and focus groups were also held at non-Olympic comparison sites. Data were also collected through the observation of meetings and document review. The data were analysed using template analysis in line with the communication–human information processing (C–HIP) model. The transfer of knowledge into and out of the Olympic Park, and the impact of the communication processes on workers, were key issues identified from the analysis. The results were used to produce industry recommendations that are applicable beyond the realm of a mega project. Important recommendations include, but are not limited to, the important role of the client, the need for planning and the focus on workers’ comprehension and safety behaviour. The most important recommendation was that methods used at the Olympic Park should be used on more traditional projects

Uptake of silicon in barley under contrasting drought regimes

Purpose: Silicon (Si) accumulation in plant tissues plays a vital role in alleviating biotic and abiotic stresses, including drought. Temperate regions are predicted to experience reductions in the quantity and frequency of rainfall events, potentially impacting plant Si uptake via the transpiration stream. Despite the importance for predicting plant responses to Si amendments, the effects of changes in rainfall patterns on Si uptake in cereals have not been characterised. Methods: Five watering regimes were applied based on predicted precipitation scenarios, varying the quantity of water delivered (ambient, 40% or 60% reduction) and watering frequency (40% reduction in quantity, applied 50% or 25% of ambient frequency), and the effects on growth and leaf Si concentrations of a barley landrace and cultivar were determined. Results: Reductions in the quantity of water reduced plant growth and yield, whereas reducing the watering frequency had little impact on growth, and in some cases partially ameliorated the negative effects of drought. Reductions in quantity of water lowered leaf Si concentrations in both the cultivar and landrace, although this effect was alleviated under the drought/deluge watering regime. The landrace had greater leaf Si concentration than the cultivar regardless of watering regime, and under ambient watering deposited Si in all cells between trichomes, whereas the cultivar exhibited gaps in Si deposition. Conclusion: The impact of future reductions in rainfall on barley productivity will depend upon how the water is delivered, with drought/deluge events likely to have smaller effects on yield and on Si uptake than continuous drought

No evidence for age-related differences in mtRNA quality in the female germline

Mitochondrial quality is implicated as a contributor to declining fertility with aging. We investigated mitochondrial transcripts in oocytes and their associated cumulus cells from mice of different ages using RNA-seq. Mice aged 3 weeks, 9 weeks, and 1 year were superovulated and 48 hr later, oocyte cumulus complexes collected by follicle puncture. We did not detect any major differences that could be attributed to aging. However, mitochondrial RNA transcripts which deviated from the consensus sequence were found at a higher frequency in cumulus cells than in their corresponding oocyte. Previous investigations have shown that variation in the sequence of mtRNA transcripts is substantial, and at least some of this can be accounted for by post-transcriptional modifications which impact base calling during sequencing. Our data would be consistent with either less post-transcriptional modification in mitochondrial RNA from oocytes than cumulus cells or with lower mtDNA mutational load

Evidence for a correlation between the sizes of quiescent galaxies and local environment to z ~ 2

We present evidence for a strong relationship between galaxy size and environment for the quiescent population in the redshift range 1 < z < 2. Environments were measured using projected galaxy overdensities on a scale of 400 kpc, as determined from ~ 96,000 K-band selected galaxies from the UKIDSS Ultra Deep Survey (UDS). Sizes were determined from ground-based K-band imaging, calibrated using space-based CANDELS HST observations in the centre of the UDS field, with photometric redshifts and stellar masses derived from 11-band photometric fitting. From the resulting size-mass relation, we confirm that quiescent galaxies at a given stellar mass were typically ~ 50 % smaller at z ~ 1.4 compared to the present day. At a given epoch, however, we find that passive galaxies in denser environments are on average significantly larger at a given stellar mass. The most massive quiescent galaxies (M_stellar > 2 x 10^11 M_sun) at z > 1 are typically 50 % larger in the highest density environments compared to those in the lowest density environments. Using Monte Carlo simulations, we reject the null hypothesis that the size-mass relation is independent of environment at a significance > 4.8 sigma for the redshift range 1 < z < 2. In contrast, the evidence for a relationship between size and environment is much weaker for star-forming galaxies.Comment: Accepted for publication in MNRAS. 16 pages, 11 figures, 6 table