Out of the Legal Wilderness: Peacetime Espionage, International Law and the Existence of Customary Exceptions

This Article demonstrates that peacetime espionage does not benefit from permissive customary international law exceptions. The mainstream view contends that, though peacetime espionage may contravene international law, developments in customary international law (CIL) nevertheless undercut State responsibility for such conduct. The gist of this view is that acts of espionage benefit from permissive CIL exceptions because its practice is widespread and accepted within the international society. However, the mainstream literature has rarely-if ever-meaningfully engaged with the practice of espionage in an effort to tease out the objective and subjective elements supportive of customary espionage exceptions. This Article closes this gap and debunks the mainstream view. We show that, although widespread, most acts of espionage are committed in secret and, as such, they cannot qualify as State practice for the purpose of CIL formation. We further demonstrate that States have failed to issue expressions of the subjective element in support of customary espionage exceptions. We conclude by suggesting that, while States are entitled to develop customary espionage exceptions in the future, for now they have yet to come out of the legal wilderness

Out of the Legal Wilderness: Peacetime Espionage, International Law and the Existence of Customary Exceptions

This Article demonstrates that peacetime espionage does not benefit from permissive customary international law exceptions. The mainstream view contends that, though peacetime espionage may contravene international law, developments in customary international law (CIL) nevertheless undercut State responsibility for such conduct. The gist of this view is that acts of espionage benefit from permissive CIL exceptions because its practice is widespread and accepted within the international society. However, the mainstream literature has rarely-if ever-meaningfully engaged with the practice of espionage in an effort to tease out the objective and subjective elements supportive of customary espionage exceptions. This Article closes this gap and debunks the mainstream view. We show that, although widespread, most acts of espionage are committed in secret and, as such, they cannot qualify as State practice for the purpose of CIL formation. We further demonstrate that States have failed to issue expressions of the subjective element in support of customary espionage exceptions. We conclude by suggesting that, while States are entitled to develop customary espionage exceptions in the future, for now they have yet to come out of the legal wilderness

An exploration of the ballistic resistance of multilayer graphene polymer composites

The response of multilayer graphene/polyvinyl alcohol (MLG/PVA) films were studied under quasi-static (Q.S.) and dynamic edge-clamped transverse loading. The 10 μm thick films, reinforced by ∼35 vol.% MLG and measuring 85 mm square were fabricated by liquid exfoliation of the graphene followed by filtration of the MLG/PVA dispersion. The responses of the MLG/PVA films were compared with those of equal areal mass films of pure PVA and aluminum. The moderately conductive (∼10−2 S cm−1) MLG/PVA films had a Young’s modulus approximately twice that of PVA and a low strain rate (10−3 s−1) peak strength that was about 50% higher. Moreover, while the MLG/PVA films had a tensile strength lower than the Al films, they had a higher load carrying capacity compared to the Al films and were stiffer than the PVA films under Q.S. transverse loading. The ballistic limit of the MLG/PVA films was ∼50% higher than the Al films but the higher ductility of the parent PVA resulted in the pure PVA films having a higher ballistic resistance. The ballistic resistance of the MLG/PVA is well predicted by a membrane stretching analysis and this enables us to present an outlook on the ballistic resistance potential of graphene/PVA composites comprising aligned large flakes.The work was supported by the Office of Naval Research Grant N62909-15-1-N058 (Program manager, Dr. Judah Goldwasser). Dr. B.P. Russell was supported by a Ministry of Defence/Royal Academy of Engineering Research Fellowship (Grant Number RG60007)

Affordable Low Cost Optical Tracking for VR

A low-cost optical tracking system can lead the way to affordable realism and provide an alternative communication interface to conventional user-computer interaction methodologies. The main aim of this project was to prove that it is possible to create a low-cost optical tracking system that is easy to use, provides a high level of accuracy and has low latency Although many optical tracking systems exist today, their high cost leaves such technology out of reach of many people. By aiming to reduce the cost of the system to as low as a couple of hundred rand, this project aims to make optical tracking technology available to a wide variety of users

Creatine transporter (SLC6A8) knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle.

The present study aimed to investigate whether skeletal muscle from whole body creatine transporter (CrT; SLC6A8) knockout mice (CrT(-/y)) actually contained creatine (Cr) and if so, whether this Cr could result from an up regulation of muscle Cr biosynthesis. Gastrocnemius muscle from CrT(-/y) and wild type (CrT(+/y)) mice were analyzed for ATP, Cr, Cr phosphate (CrP), and total Cr (TCr) content. Muscle protein and gene expression of the enzymes responsible for Cr biosynthesis L-arginine:glycine amidotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT) were also determined as were the rates of in vitro Cr biosynthesis. CrT(-/y) mice muscle contained measurable (22.3 ± 4.3 mmol.kg(-1) dry mass), but markedly reduced (P < 0.05) TCr levels compared with CrT(+/y) mice (125.0 ± 3.3 mmol.kg(-1) dry mass). AGAT gene and protein expression were higher (~3 fold; P < 0.05) in CrT(-/y) mice muscle, however GAMT gene and protein expression remained unchanged. The in vitro rate of Cr biosynthesis was elevated 1.5 fold (P < 0.05) in CrT(-/y) mice muscle. These data clearly demonstrate that in the absence of CrT protein, skeletal muscle has reduced, but not absent, levels of Cr. This presence of Cr may be at least partly due to an up regulation of muscle Cr biosynthesis as evidenced by an increased AGAT protein expression and in vitro Cr biosynthesis rates in CrT(-/y) mice. Of note, the up regulation of Cr biosynthesis in CrT(-/y) mice muscle was unable to fully restore Cr levels to that found in wild type muscle

Evidence for global cooling in the Late Cretaceous

PublishedArticleThe Late Cretaceous ‘greenhouse’ world witnessed a transition from one of the warmest climates of the past 140 million years to cooler conditions, yet still without significant continental ice. Low-latitude sea surface temperature (SST) records are a vital piece of evidence required to unravel the cause of Late Cretaceous cooling, but high-quality data remain illusive. Here, using an organic geochemical palaeothermometer (TEX86), we present a record of SSTs for the Campanian–Maastrichtian interval (~83–66 Ma) from hemipelagic sediments deposited on the western North Atlantic shelf. Our record reveals that the North Atlantic at 35 °N was relatively warm in the earliest Campanian, with maximum SSTs of ~35 °C, but experienced significant cooling (~7 °C) after this to <~28 °C during the Maastrichtian. The overall stratigraphic trend is remarkably similar to records of high-latitude SSTs and bottom-water temperatures, suggesting that the cooling pattern was global rather than regional and, therefore, driven predominantly by declining atmospheric pCO2 levels.We gratefully acknowledge funding from the German Science Foundation (DFG Research Stipend Li 2177/1-1 to C.L.), a Royal Society (UK) URF (S.A.R.), a NERC (UK) grant (J.A.L.), a NERC (UK) studentship (K.L.), The Curry Fund of UCL (C.L.), the Cushman Foundation for Foraminiferal Research (J.M. Resig Fellowship to F.F.) and the Spanish Ministerio de Ciencia e Innovación project CGL2011-22912, co-financed by the European Regional Development Fund (I.P.-R., J.A.A., J.A.L.). We thank T. Dunkley-Jones and J. Young for assistance in collecting the samples and S. Schouten for providing TEX86L data from Demerara Rise. This paper is dedicated to Ernie Russell, who sadly died after submission of the manuscript

Patient-reported outcome measures in systemic sclerosis–related interstitial lung disease for clinical practice and clinical trials

This is the author accepted manuscript. The final version is available from SAGE via the DOI in this record. Systemic sclerosis (SSc) is a progressive vasculopathic, fibrosing autoimmune condition, portending significant mortality; wherein interstitial lung disease (ILD) is the leading cause of death. Although lacking a definitive cure, therapeutics for (SSc-ILD) that stave progression exist with further promising primary and adjuvant compounds in development, as well as interventions to reduce symptom burden and increase quality of life. To date, there has been a significant but varied history related to systemic sclerosis–related interstitial lung disease trial design and endpoint designation. This is especially true of endpoints measuring patient-reported perceptions of efficacy and tolerability. This article describes the underpinnings and complexity of the science, methodology, and current state of patient-reported outcome measures used in (SSc-ILD) systemic sclerosis–related interstitial lung disease in clinical practice and trials.National Institutes of Health (NIH

Survey of the quality of experimental design, statistical analysis and reporting of research using animals

For scientific, ethical and economic reasons, experiments involving animals should be appropriately designed, correctly analysed and transparently reported. This increases the scientific validity of the results, and maximises the knowledge gained from each experiment. A minimum amount of relevant information must be included in scientific publications to ensure that the methods and results of a study can be reviewed, analysed and repeated. Omitting essential information can raise scientific and ethical concerns. We report the findings of a systematic survey of reporting, experimental design and statistical analysis in published biomedical research using laboratory animals. Medline and EMBASE were searched for studies reporting research on live rats, mice and non-human primates carried out in UK and US publicly funded research establishments. Detailed information was collected from 271 publications, about the objective or hypothesis of the study, the number, sex, age and/or weight of animals used, and experimental and statistical methods. Only 59% of the studies stated the hypothesis or objective of the study and the number and characteristics of the animals used. Appropriate and efficient experimental design is a critical component of high-quality science. Most of the papers surveyed did not use randomisation (87%) or blinding (86%), to reduce bias in animal selection and outcome assessment. Only 70% of the publications that used statistical methods described their methods and presented the results with a measure of error or variability. This survey has identified a number of issues that need to be addressed in order to improve experimental design and reporting in publications describing research using animals. Scientific publication is a powerful and important source of information; the authors of scientific publications therefore have a responsibility to describe their methods and results comprehensively, accurately and transparently, and peer reviewers and journal editors share the responsibility to ensure that published studies fulfil these criteria

The Iowa Homemaker vol.22, no.8

Keeping Up With Today, Virginia Brainard, page 4 Letter from Overseas, Martha Kitchen, page 5 Nutrition in the Nursery, Phyllis Lee, page 6 Iowa Staters Feed Wartime Washington, Eileen Dudgeon, page 7 What’s New in Home Economics, Helen Horton, page 8 We Britons Tighten Our Belts, Mr. and Mrs. Sharp, page 10 In a Teacher’s World, Betty Roth, page 11 Across Alumnae Desks, Mary Ellen Sullivan, page 12 Alums in the News, Janet Russell, page 14 We Recommend, Eileen Dudgeon, page 15 Textiles See Action, Ann Mason, page 1

Genetic Diversity in New Members of the Reticulocyte Binding Protein Family in Thai Plasmodium vivax Isolates

Background Plasmodium vivax merozoites specifically invade reticulocytes. Until recently, two reticulocyte-binding proteins (Pvrbp1 and Pvrbp2) expressed at the apical pole of the P. vivax merozoite were considered to be involved in reticulocyte recognition. The genome sequence recently obtained for the Salvador I (Sal-I) strain of P. vivax revealed additional genes in this family, and in particular Pvrbp2a, Pvrbp2b (Pvrbp2 has been renamed as Pvrbp2c) and two pseudogenes Pvrbp2d and Pvrbp3. It had been previously found that Pvrbp2c is substantially more polymorphic than Pvrbp1. The primary goal of this study was to ascertain the level of polymorphism of these new genes. Methodology/Principal Findings The sequence of the Pvrbp2a, Pvrbp2b, Pvrbp2d and Pvrbp3 genes were obtained by amplification/cloning using DNA purified from four isolates collected from patients that acquired the infection in the four cardinal regions of Thailand (west, north, south and east). An additional seven isolates from western Thailand were analyzed for gene copy number variation. There were significant polymorphisms exhibited by these genes (compared to the reference Sal-I strain) with the ratio of mutations leading to a non-synonymous or synonymous amino acid change close to 3∶1 for Pvrbp2a and Pvrbp2b. Although the degree of polymorphism exhibited by these two genes was higher than that of Pvrbp1, it did not reach the exceptional diversity noted for Pvrbp2c. It was interesting to note that variations in the copy number of Pvrbp2a and Pvrbp2b occurred in some isolates. Conclusions/Significance The evolution of different members of the Pvrbp2 family and their relatively high degree of polymorphism suggests that the proteins encoded by these genes are important for parasite survival and are under immune selection. Our data also shows that there are highly conserved regions in rbp2a and rbp2b, which might provide suitable targets for future vaccine development against the blood stage of P. vivax