Cityscape protection using VR and eye tracking technology

Abstract(#br)The traditional method for reconstructing cityscape relies greatly on the subjective judgment of designers, which makes the cityscape simple and homogenized. This paper aims to propose a new integrated approach to protect and design cityscape based on virtual reality (VR) and eye tracking technology. Through the integration and quantification of the eye tracking data and the protocol analysis data in the VR environment, this research has revealed the mechanism of identifying the cityscape features, and discovered the differences in the perception of the cityscape features by different people, thus proposing the multi-cultural integrated strategy for protecting cityscape. This research is of great significance for building a human-oriented scientific planning and protection method and promoting the application of cutting-edge digital technology in the field of smart city governance

Characterization of rock thermophysical properties and factors affecting thermal conductivity−A case study of Datong Basin, China

Rock thermal physical properties play a crucial role in understanding deep thermal conditions, modeling the thermal structure of the lithosphere, and discovering the evolutionary history of sedimentary basins. Recent advancements in geothermal exploration, particularly the identification of high-temperature geothermal resources in Datong Basin, Shanxi, China, have opened new possibilities. This study aims to characterize the thermal properties of rocks and explore factors influencing thermal conductivity in basins hosting high-temperature geothermal resources. A total of 70 groups of rock samples were collected from outcrops in and around Datong Basin, Shanxi Province. Thermal property tests were carried out to analyze the rock properties, and the influencing factors of thermal conductivity were studied through experiments at different temperature and water-filled states. The results indicate that the thermal conductivity of rocks in Datong, Shanxi Province, typically ranges from 0.690 W/(m·K) to 6.460 W/(m·K), the thermal diffusion coefficient ranges from 0.441 mm2/s to 2.023 mm2/s, and the specific heat capacity of the rocks ranges from 0.569 KJ/(kg·°C) to 1.117 KJ/(kg·°C). Experimental results reveal the impact of temperature and water saturation on the thermal conductivity of the rock. The thermal conductivity decreases with increasing temperature and rises with high water saturation. A temperature correction formula for the thermal conductivity of different lithologies in the area is proposed through linear fitting. The findings from this study provide essential parameters for the assessment and prediction, development, and utilization of geothermal resources in the region and other basins with typical high-temperature geothermal resource

Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice.

Rhein, a component derived from rhubarb, has been proven to possess anti-inflammatory properties. Here, we show that rhein mitigates obesity by promoting adipose tissue thermogenesis in diet-induced obese mice. We construct a macrophage-adipocyte co-culture system and demonstrate that rhein promotes adipocyte thermogenesis through inhibiting NLRP3 inflammasome activation in macrophages. Moreover, clues from acetylome analysis identify SIRT2 as a potential drug target of rhein. We further verify that rhein directly interacts with SIRT2 and inhibits NLRP3 inflammasome activation in a SIRT2-dependent way. Myeloid knockdown of SIRT2 abrogates adipose tissue thermogenesis and metabolic benefits in obese mice induced by rhein. Together, our findings elucidate that rhein inhibits NLRP3 inflammasome activation in macrophages by regulating SIRT2, and thus promotes white adipose tissue thermogenesis during obesity. These findings uncover the molecular mechanism underlying the anti-inflammatory and anti-obesity effects of rhein, and suggest that rhein may become a potential drug for treating obesity

Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma

Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 patients with HCC. We show that HBV is prone to integrate into rare fragile sites and functional genomic regions including CpG islands. We observe a distinct pattern in the preferential sites of HBV integration between tumour and non-tumour tissues. HBV insertional sites are significantly enriched in the proximity of telomeres in tumours. Recurrent HBV target genes are identified with few that overlap. The overall HBV integration frequency is much higher in tumour genomes of males than in females, with a significant enrichment of integration into chromosome 17. Furthermore, a cirrhosis-dependent HBV integration pattern is observed, affecting distinct targeted genes. Our data suggest that HBV integration has a high potential to drive oncogenic transformation

Association of Genes in the High-Density Lipoprotein Metabolic Pathway with Polypoidal Choroidal Vasculopathy in Asian Population: A Systematic Review and Meta-Analysis

Purpose. To assess the association of genes in the high-density lipoprotein metabolic pathway (HDLMP) with polypoidal choroidal vasculopathy (PCV) and the genetic difference in the HDLMP between PCV and age-related macular degeneration (AMD). Methods. We performed a literature search in EMBASE, PubMed, and Web of Science for genetic studies on 7 single nucleotide polymorphisms (SNPs) from 5 genes in the HDLMP including cholesteryl ester transfer protein (CETP), hepatic lipase (LIPC), lipoprotein lipase (LPL), ATP-binding cassette transporter A1 (ABCA1), and ATP-binding cassette transporter G1 (ABCG1) in PCV. All studies were published before September 30, 2017, without language restriction. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) of each polymorphism were estimated. We also compared the association profiles between PCV and AMD and performed a sensitivity analysis. Results. Our result is based on 43 articles. After excluding duplicates and articles without complete information, 7 studies were applicable to meta-analysis. 7 polymorphisms were meta-analyzed: CETP rs2303790/rs3764261, LIPC rs10468017/rs493258, LPL rs12678919, ABCA1 rs1883025, and ABCG1 rs57137919. We found that in Asian population, CETP rs3764261 (T allele; OR = 1.46; 95% CI: 1.28–1.665, P0.05). The sensitivity analysis validated the significance of our analysis. Conclusions. Our study revealed 7 polymorphisms in 5 genes. Among them, CETP (rs3764261/rs2303790) and ABCG1 (rs57137919) were the major susceptibility genes for PCV in Asian population and ABCG1 (rs57137919) showed allelic diversity between PCV and AMD. Since the size for PCV and AMD was small, we need to study these genes genotyping in larger samples

A Serendipitous Discovery of GeV Gamma-Ray Emission from Supernova 2004dj in a Survey of Nearby Star-forming Galaxies with Fermi-LAT

The interaction between a supernova ejecta and the circumstellar medium drives a strong shock wave that accelerates particles (i.e., electrons and protons). The radio and X-ray emission observed after the supernova explosion can be interpreted as synchrotron emission from accelerated electrons. The accelerated protons are expected to produce GeV–TeV gamma-ray emission via proton–proton collisions, but the flux is usually low since only a small fraction of the supernova kinetic energy is converted into the shock energy at the very early time. The low gamma-ray flux of the nearest supernova explosion, SN 1987A, agrees with this picture. Here we report a serendipitous discovery of a fading GeV gamma-ray source in spatial coincidence with one of the nearest and brightest supernova—SN 2004dj from our gamma-ray survey of nearby star-forming galaxies with Fermi-LAT. The total gamma-ray energy released by SN 2004dj is about 6 × 1047 erg. We interpret this gamma-ray emission arising from the supernova ejecta interacting with a surrounding high-density shell, which decelerates the ejecta and converts ~1% of the SN kinetic energy to relativistic protons