Similar impairments shown on a neuropsychological test battery in adolescents with high-functioning autism and early onset schizophrenia: A two-year follow-up study

Introduction: Cognitive impairments are common in both Autism Spectrum Disorders (ASD) and schizophrenia, but it is unclear whether the pattern of difficulties is similar or different in the two disorders. This cross-sectional and longitudinal study compared the neuropsychological functioning in adolescents with ASD with adolescents with Early Onset Schizophrenia (EOS). Methods: At baseline and at two-year follow-up, participants were assessed with a brief neuropsychological test battery measuring executive functions, visual and verbal learning, delayed recall and recognition and psychomotor speed. Results: We found similar levels of neuropsychological impairment across groups and over time in the adolescents with ASD or EOS. Adolescents in both groups did not improve significantly on verbal learning, verbal delayed recall, visual learning, visual delayed recall or visual delayed recognition, and both groups performed poorer on verbal recognition. Both groups improved on measures of psychomotor processing and executive functions. Conclusion: The findings suggest that it may be difficult to differentiate adolescents with EOS and ASD based on neuropsychological task performance. An implication of the results is that adolescents with either disorder may benefit from a similar approach to the treatment of cognitive impairment in the disorders.acceptedVersio

Cognitive functioning in a group of adolescents at risk for psychosis.

peer reviewedCognitive deficits are a core feature of schizophrenia, and impairments are present in groups at-risk for psychosis. Most at-risk studies include young adults and not younger age-groups, such as adolescents. Participants are usually help-seeking individuals, even though risk factors may also be present in non-help seeking adolescents. We aim to explore cognitive functions in a group of non-help-seeking 15-year-old adolescents at risk for psychosis compared to age- and gender matched controls, including particular focus on specific cognitive domains. Hundred participants (mean age = 15.3) were invited after completing the 14-year-old survey distributed by the Norwegian Mother-, Father- and Child Study. At-risk adolescents were selected based on high scores on 19 items assessing both psychotic experiences and anomalous self-experiences. Matched controls were selected from the same sample. Cognitive functioning was assessed using the MATRICS Consensus Cognitive Battery and IQ using Wechsler's Abbreviated Test of Intelligence. We found that the adolescents at-risk for psychosis had significantly poorer scores than controls on the composite score of the MCCB. IQ scores were also significantly lower in the at-risk group. The results highlight general cognitive deficits as central in a group of non-help-seeking adolescents at-risk for psychosis. Results indicate that the development of cognitive impairments starts early in life in at-risk groups. It is still unclear whether specific cognitive domains, such as verbal learning, are related to psychotic symptoms or may be specifically vulnerable to symptoms of depression and anxiety

The psychological well-being of Norwegian adolescents exposed in utero to radiation from the Chernobyl accident

<p>Abstract</p> <p>Background</p> <p>On 26 April 1986, the Chernobyl nuclear power plant suffered an accident. Several areas of central Norway were heavily affected by far field radioactive fallout. The present study focuses on the psychological well-being of adolescents who were exposed to this radiation as fetuses.</p> <p>Methods</p> <p>The adolescents (n = 53) and their mothers reported their perceptions of the adolescents' current psychological health as measured by the Youth Self Report and Child Behaviour Checklist.</p> <p>Results</p> <p>In spite of previous reports of subtle cognitive deficits in these exposed adolescents, there were few self-reported problems and fewer problems reported by the mothers. This contrasts with findings of studies of children from the former Soviet Union exposed in utero, in which objective measures are inconsistent, and self-reports, especially by mothers, express concern for adolescents' cognitive functioning and psychological well-being.</p> <p>Conclusion</p> <p>In the current paper, we explore possible explanations for this discrepancy and suggest that protective factors in Norway, in addition to perceived physical and psychological distance from the disaster, made the mothers less vulnerable to Chernobyl-related anxiety, thus preventing a negative effect on the psychological health of both mother and child.</p

Maintained improvement in neurocognitive function in major depressive disorders 6 months after ECT

Both impaired and improved cognitive function after electroconvulsive treatment (ECT) in major depressive disorder (MDD) patients may occur. We have previously found improved cognitive function 6 weeks after ECT in this group. The aim of this study was to report 6-month follow-up results from the same prospective project monitoring cognitive effects of ECT. Thirty-one patients with major depressive disorder were assessed with the MATRICS Consensus Cognitive Battery (MCCB), the Everyday Memory Questionnaire (EMQ), and the Montgomery-Åsberg Depression Rating Scale (MADRS) prior to, 6 weeks, and 6 months after ECT.Compared to baseline, the Speed of Processing, Attention/Vigilance, and Reasoning/Problem Solving test results were significantly improved. The depression score was significantly reduced. There were no changes in subjective memory complaint. There were no significant relationship between the EMQ and the MCCB subtests, but a significant correlation between current depression level and the EMQ.Six months after ECT the cognitive improvement reported at 6 weeks follow-up was maintained and extended. The corresponding decrease in depressive symptoms and stability in subjectively reported memory complaints suggests that the antidepressant effects of ECT do not occur at the expense of cognitive function

The Research evidence for schizophrenia as a neurodevelopmental disorder

Schizophrenia is a neurodevelopmental disorder that starts very early. In this review we describe the empirical evidence for the neurodevelopmental model. First, by outlining the roots of psychological research that laid the foundation of the model. Thereafter, describing cognitive dysfunction observed in schizophrenia, and the course of cognitive functioning in the illness. Then, research findings that speak for and studies that speak against the view that schizophrenia is a degenerative process is discussed. We find that there is ample evidence that cognitive disturbance is a core element in schizophrenia. However, we have limited understanding of what initiates the abnormal development. This the paper ends with pointing out some of the factors that may trigger the deviant neurocognitive development in schizophrenia. This research has been published in Scandinavian Journal of Psychology. © 2018 Wile

A review of factors associated with severe violence in schizophrenia

Background: There is a modest but consistent association between violence and schizophrenia. The consequences of serious violence could be catastrophic for the victims, as well as the patients themselves and the community. Any knowledge that would help to prevent acts of serious violence would be of considerable value for the individual and the society. Aim: To identify external and clinical risk factors for serious violence in schizophrenia, in addition to considering the strength of the association between the factors assessed and severe violence. Methods: This was accomplished by a literature survey. One-hundred and two relevant papers were identified that were published during the past 20 years. Forty-four papers were assessed for eligibility. In all, 27 studies including clinical or cognitive variables were reviewed systematically. An effect size was reported where an odds ratio (OR) could be identified or calculated from available data. Five external factors and six clinical domains were evaluated. Results: Substance abuse is robustly linking schizophrenia and violence. Among the clinical factors, insight, impulsivity, psychopathy, motor speed and a global measure of cognition are the factors with the strongest empirical evidence for an association with severe violence. Conclusion: This is the first systematic review of risk factors for severe violence in schizophrenia, in which a great number of clinical and external factors have been evaluated. Most of the clinical factors have been compared on effect size. The identified factors that represent an increased risk of violence in patients with schizophrenia should be included in risk assessments

Neurognitive function and symptom remission 2 years after ECT in major depressive disorders

Background: There is a lack of knowledge of possible cognitive side effects of electroconvulsive therapy (ECT) beyond the first few months after treatment. We aim to describe cognitive effects and symptom remission 2 years after ECT in major depressive disorders. Method: Twenty-seven depression patients were assessed with the MATRICS Consensus Cognitive Battery (MCCB) and the Everyday Memory Questionnaire (EMQ) before and 2 years after ECT. Their scores were compared with those of healthy matches. Depression and remission status were assessed with the Montgomery–Åsberg Depression Rating Scale (MADRS). Main statistical analyses were ANOVAs and linear mixed model tests. Results: At baseline, the patient group was significantly impaired on 7 of 10 cognitive tests compared to the control group. Two years later, this gap was reduced to impairment on 5 of 10 tests. Within the patient group, neurocognitive function either increased significantly from baseline to follow-up, or there was no change. Two years after ECT, 62.9% of the patients were in remission. Those in remission reported better subjective memory function, but displayed no different neuropsychological test results, compared to the non-remitters. Limitations: Major limitations were low sample size and lack of uniform ECT procedure. Conclusions: We found improved neurocognitive function 2 years after ECT. This effect occurred regardless of remission status, suggesting that ECT induces unique cognitive boosting processes

The relationship between IQ and performance on the MATRICS consensus cognitive battery

AbstractThe associations between IQ and individual tests of neurocognitive function are well studied. However, there is a lack of information as to how IQ relates to performance on neuropsychological test batteries as a whole and in the same individuals. In this study, 250 healthy participants aged 20-69 years were tested with the Wechsler Abbreviated Scale of Intelligence (WASI) and the MATRICS Consensus Cognitive Battery (MCCB). In correlation analyses, IQ was significantly related to all MCCB scores, except the Social Cognition domain. Hierarchical regression analyses including gender, age, and education confirmed this association. For overall cognitive function, 50% of the variance was explained by IQ and demographic characteristics. For the domains Speed of Processing, Working Memory, Visual and Verbal Learning, IQ explained a larger proportion of the variance than the demographic factors did. The implication is that these domains may provide information of a person’s intelligence level

Innsatspersonell fikk større tro på egen mestring etter terrorangrepene 22. juli 2011

Bakgrunn: Deltakelsen i redningsarbeidet etter terrorhandlingene 22. juli 2011 var krevende, uvant og uforutsigbart. Arbeid knyttet til større hendelser kan være belastende, men også gi økt opplevelse av vekst. Det er imidlertid få studier som er knyttet til opplevelsen av å få større tillit til utøvelsen av egen innsats. Hensikt: Å undersøke i hvilken grad innsatspersonell er mer forberedt på å mestre liknende situasjoner i fremtiden. Vi ønsket også å finne ut hvilke faktorer som er forbundet med bedre mestringsopplevelse. Metode: Ti måneder etter terrorhandlingene 22. juli 2011 deltok helsepersonell, politi, brann- og redningsetaten og organiserte frivillige i en tverrsnittsundersøkelse om faglige utfordringer, opplevd støtte og personlige reaksjoner etter hendelsene. Kvalitative data utdyper resultatene. Resultat: Svarprosenten var 62 (1734/2801). Alle gruppene rapporterte at de var mer forberedt på å mestre liknende situasjoner i fremtiden (gjennomsnittsverdi 3,5–3,7; skala 1–5). Tidlig oppstart av arbeidet (OR 1,5, KI 1,2–1,9), flere vitneopplevelser (OR 1,5, KI 1,2–1,9) og høyere grad av rolleklarhet (OR 1,5, KI 1,2–1,9) var forbundet med økt opplevelse av mestring. Sammenliknet med personer som var yngre enn 30 år, var det lavere mestringsopplevelse i aldersgruppen 30–49 år (OR 0,7, KI 0,5–0,9 (p = 0,05) og aldersgruppen 50 år eller eldre (OR 0,5, KI 0,3–0,7, p < 0,001). Konklusjon: Virkelige hendelser gir en læringsmulighet man ikke kan oppnå teoretisk eller ved øvelser. Større belastning var forbundet med økt mestringsopplevelse. Omsorgsfull ledelse samt en opplevelse av samarbeid og stolthet knyttet til innsatsen kan også ha bidratt til økt mestringsfølelse