Discovery of os cordis in the cardiac skeleton of chimpanzees (Pan troglodytes)

Cardiovascular diseases, especially idiopathic myocardial fibrosis, is one of the most significant causes of morbidity and mortality in captive great apes. This study compared the structure and morphology of 16 hearts from chimpanzees (Pan troglodytes) which were either healthy or affected by myocardial fibrosis using X-ray microtomography. In four hearts, a single, hyperdense structure was detected within the right fibrous trigone of the cardiac skeleton. High resolution scans and histopathology revealed trabecular bones in two cases, hyaline cartilage in another case and a focus of mineralised fibro-cartilaginous metaplasia with endochondral ossification in the last case. Four other animals presented with multiple foci of ectopic calcification within the walls of the great vessels. All hearts affected by marked myocardial fibrosis presented with bone or cartilage formation, and increased collagen levels in tissues adjacent to the bone/cartilage, while unaffected hearts did not present with os cordis or cartilago cordis. The presence of an os cordis has been described in some ruminants, camelids, and otters, but never in great apes. This novel research indicates that an os cordis and cartilago cordis is present in some chimpanzees, particularly those affected by myocardial fibrosis, and could influence the risk of cardiac arrhythmias and sudden death

Effects of Medicinal Herb Salvia Miltiorrhiza on Osteoblastic Cell Line of MC3T3-E1

A great deal of recent evidence has indicated a relationship between calcification in the coronary arteries and coronary heart disease [1–4]. Methods such as spiral CT [5], electron beam CT [6,7], digital subtraction fluoroscopy [8], and intravascular ultrasound [9,10] have been used to detect this “indicator” calcification, either directly in the coronaries or in indicator arteries such as the brachials, carotids, or illiacs [11]. The nonzero threshold for CT detection of calcium (2 mm2 [12]) produces a high negative predictive value for greater than 50% stenosis but relatively low positive predictive value [13]. Conventional ultrasound, even intra-arterial, has low sensitivity and specificity for calcification but good sensitivity for intimai thickening [14]. Recent histologic studies in vessels which have not been decalcified have shown the ubiquitous presence of calcification in the plaque, the media and the fibrous regions of diseased arteries and not normal arteries [15]. These results indicate a place for a noninvasive method of detecting early calcification which could be used as a preventive medicine guide for at-risk individuals as mentioned by Loecker et al. [16]. The acoustic emission imaging and spectra methods described below are candidates for such noninvasive methods

Measurements of hadron production in π++C and π++Be interactions at 60 GeV/c

Precise knowledge of hadron production rates in the generation of neutrino beams is necessary for accelerator-based neutrino experiments to achieve their physics goals. NA61/SHINE, a large-acceptance hadron spectrometer, has recorded hadron+nucleus interactions relevant to ongoing and future long-baseline neutrino experiments at Fermi National Accelerator Laboratory. This paper presents three analyses of interactions of 60  GeV/c π+ with thin, fixed carbon and beryllium targets. Integrated production and inelastic cross sections were measured for both of these reactions. In an analysis of strange, neutral hadron production, differential production multiplicities of K0S, Λ and ¯Λ were measured. Lastly, in an analysis of charged hadron production, differential production multiplicities of π+, π−, K+, K− and protons were measured. These measurements will enable long-baseline neutrino experiments to better constrain predictions of their neutrino flux in order to achieve better precision on their neutrino cross section and oscillation measurements

Measurements of π± , K± and proton double differential yields from the surface of the T2K replica target for incoming 31 GeV/c protons with the NA61/SHINE spectrometer at the CERN SPS

Measurements of the π±, K±, and proton double differential yields emitted from the surface of the 90-cm-long carbon target (T2K replica) were performed for the incoming 31 GeV/c protons with the NA61/SHINE spectrometer at the CERN SPS using data collected during 2010 run. The double differential π± yields were measured with increased precision compared to the previously published NA61/SHINE results, while the K± and proton yields were obtained for the first time. A strategy for dealing with the dependence of the results on the incoming proton beam profile is proposed. The purpose of these measurements is to reduce significantly the (anti)neutrino flux uncertainty in the T2K long-baseline neutrino experiment by constraining the production of (anti)neutrino ancestors coming from the T2K target