Kompleksi paladijuma(II) sa ligandima R2edda tipa, deo III - diizobutil-(s,s)-2,2'-(1,2,-etandiildiimino)-di(4-metilpentanoat)-dihidrohlorid i njegov kompleks sa paladijumom(II) - sinteza i karakterizacija

A new R(2)edda-type ester, diisobutyl (SS)-2,2'-(1,2-ethane-diyldiimino)di(4-methylpentanoate) dihydrochloride, [(S,S)-H(2)iBu(2)eddl]Cl-2, 1, and its palladium(II) complex, dichloro(diisobutyl (SS)-2,2'-(1,2-ethanediyldiimino)di(4-methylpentanoate))palladium(II), [PdCl2{(S,S)-iBu(2)eddl}], 2, were synthesized and characterized by elemental analysis, as well as IR and NMR spectroscopy. It was found that complex 2 was obtained as mixture of two diastereoisomers, observed in NMR spectra. The crystal structure of compound I was determined by X-ray diffraction studies and is described. The isolated crystals consisted of one dicationic species [(SS)-H(2)iBu(2)eddl](2+) and two Cl-. The crystal system was tetragonal with the space group P4(2). Hydrogen bonds significant for the manner of packing are N-H1N center dot center dot center dot Cl, 3.049(3) angstrom, 159(3)degrees and N-H2N center dot center dot center dot Cl, 3.100(3) angstrom, 164(3)degrees. An infinite chain was formed building a one layer structure, usual for these types of compounds. The C-2 symmetry axis of the compound passes through the Cl-Cl-i bond vector and lies perpendicular to the plane N2Cl2.Novi estar R2edda-tipa diizobutil-(S,S)-2,2'-(1,2-etandiildiimino)-di(4-metilpen-tanoat)-dihidrohlorid [(S,S)-H2iBu2eddl]Cl2,1, i njegov kompleks paladijuma(II), dihlorodiizobutil-(S,S)-2,2'-(1,2-etandiildiimino)-di(4-metilpentanoat)-paladijum(II) [PdCl2{(S,S)-iBu2eddl}], 2, sintetisani su i okarakterisani uz pomoć elementalne analize, IR i NMR spektroskopije. Nađeno je da je kompleks 2 dobijen kao smeša dva dijastereoizomera, što je primećeno u NMR spektrima. Kristalna struktura 1 je rešena i opisana. Izolovani kristali se sastoje iz jedne dikatjonske vrste [(S,S)-H2iBu2eddl]2+ i dva Cl-. Kristalni sistem je tetragonalan sa prostornim grupom P42. Značajne vodonične veze za način pakovanja su N-H1N•••Cl, 3,049(3) Å, 159(3)°i N-H2N...Cl, 3,100(3) Å, 164(3)°. Time se formira beskonačan lanac i jednoslojna struktura, koji su uobičajeni za ove tipove struktura. Osa simetrije C2 jedinjenja prolazi kroz C1-C1i vektor veze i leži normalno na N2Cl2 ravan. PR Projekat Ministarstva nauke Republike Srbije, br. 142010

(S,S)-N,N '-Bis(1-carboxy-2-methylpropyl)ethylenediammonium dihalide cyclopentanol tetrasolvate (halide = bromide/chloride similar or equal to 1:12)

In the crystal structure of the title compound, C(12)H(26)N(2)O(4)(2+)center dot-2(Br(0.085)Cl(0.915))(-)center dot 4C(5)H(9)OH, the complete cation is generated by crystallographic twofold symmetry. Contamination of the chloride counter-anion with bromide occured during the preparation, due to the use of 1,2-dibromoethane. One of the solvent molecules is disordered, with occupancies 0.53 (3): 0.47 (3). The crystal packing is stabilized by an infinite two dimensional center dot center dot center dot X center dot center dot center dot H-N-H center dot center dot center dot X center dot center dot center dot hydrogen-bonding network (X: Br(-)/Cl(-) similar or equal to 1:12). In addition, O-H center dot center dot center dot X and O-H center dot center dot center dot O hydrogen bonds involving solvent molecules are observed

2,2 '-{1,1 '-[2,2 '-Oxalylbis(hydrazin-2-yl-1-ylidene)]diethylidyne}dipyridinium bis(perchlorate) dihydrate

The title salt, C(16)H(18)N(6)O(2)(2+)center dot 2ClO(4)(-)center dot 2H(2)O, was obtained unintentionally as a major product in the reaction of Zn(ClO(4))(2)center dot 6H(2)O with the N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H(2)L) ligand. The (H(4)L)(2+) cation lies across a centre of inversion. The pyridiniumimine fragments of (H(4)L)(2+) adopt syn orientations. Intramolecular N-H center dot center dot center dot N and N-H center dot center dot center dot O hydrogen bonds lead to the formation of S(5) motifs. In the crystal, neighbouring cations are connected by pi-pi interactions between pyridinium units with a centroid-centroid distance of 3.600 (1) angstrom. Moreover, the crystal components are assembled into two-dimensional layers via N-H center dot center dot center dot O and O-H center dot center dot center dot O hydrogen bonds, with no direct hydrogen-bonding interactions between cations

B-Learning and Technology: Enablers for University Education Resilience. An Experience Case under COVID-19 in Spain

[EN] Innovative teaching methodologies begat blended learning, which seems to facilitate engineering students' achievement of competencies required for the 21st century and has proven to be essential to keep quality standards as university education has suffered the COVID-19 pandemic. In this paper, we approach the use of b-learning and digital technologies before the pandemic started, and how it worked like a vaccine, enabling university education resilience and facilitating the sustainability of the students learning process. A questionnaire-based study is presented, in which the data came from Aerospace Engineering students following a Mathematics subject in a Technological University in Spain. ANOVA and ANCOVA analysis provided a significant difference in the appreciation of the adaptation based on the prior application of b-learning methodologies or more traditional methodologies. Results obtained indicated that the use of digital resources and educational platforms caused a noticeable change in the students' way of learning, improving habits and digital skills.Sánchez Ruiz, LM.; Moll López, SE.; Moraño Fernández, JA.; Llobregat-Gomez, N. (2021). B-Learning and Technology: Enablers for University Education Resilience. An Experience Case under COVID-19 in Spain. Sustainability. 13(6):1-22. https://doi.org/10.3390/su13063532S12213

Hexaaqua­magnesium(II) bis­(d-camphor-10-sulfonate)

The structure of the title complex, [Mg(H2O)6](C10H15O4S)2, consists of regular octa­hedral [Mg(H2O)6]2+ cations and d-camphor-10-sulfonate anions. A three-dimensional supra­molecular architecture is formed via hydrogen-bond inter­actions [O—H⋯O = 2.723 (2)–2.833 (2) Å] to give alternating layers of [Mg(H2O)6]2+ cations and d-camphor-10-sulfonate anions. The title compound is isomorphous with the zinc, copper, cadmium and nickel analogues

On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy

The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated. Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity

Sinteza, strukturna karakterizacija i citotoksična aktivnost dva nova organorutenijum(II) kompleksa

Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(eta(6)-p-cymene)RuCl2(CH3NH(CH2)(4)NH)]PF6, complex 1) or vitamin K-3-thiosemicarbazone ([(eta(6)-p-cymene)RuCl2(K(3)tsc)], complex 2) were synthesized starting from [(eta(6)-p-cymene)(2)RuCl2](2) and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present.Sintetisana su dva nova p-cimen-rutenijum(II) kompleksa koji sadrže kao dodatne ligande N-metilpiperazin ([(h6-p-cimen)RuCl2(CH3NH(CH2)4NH)]PF6, kompleks 1) i vitamin K3-tiosemikarbazon ([(h6-p-cimen)RuCl2(K3tsc)], kompleks 2). Oba nova kompleksa dobijena su polazeći od [(h6-p-cimen)2RuCl2]2 kompleksa i odgovarajućeg liganda. Kompleksi su okarakterisani elementalnom analizom, IC, elektronsko-apsorpcionom i NMR spektroskopijom. Rendgeno-strukturna analiza kompleksa 1 pokazala je “piano-stool” geometriju. U zavisnosti od prisutnog liganda diskutovana je razlika u citotoksičnoj aktivnosti ova dva dobijena kompleksa

Comparison of chemical compounds associated with sclerites from healthy and diseased sea fan corals (Gorgonia ventalina)

© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PeerJ 5 (2017): e3677, doi:10.7717/peerj.3677.The roles of gorgonian sclerites as structural components and predator deterrents have been widely studied. Yet their role as barriers against microbes has only recently been investigated, and even less is known about the diversity and roles of the chemical compounds associated with sclerites. Here, we examine the semi-volatile organic compound fraction (SVOCs) associated with sclerites from healthy and diseased Gorgonia ventalina sea fan corals to understand their possible role as a stress response or in defense of infection. We also measured the oxidative potential of compounds from diseased and healthy G. ventalina colonies. The results showed that sclerites harbor a great diversity of SVOCs. Overall, 70 compounds were identified, the majority of which are novel with unknown biological roles. The majority of SVOCs identified exhibit multiple immune-related roles including antimicrobial and radical scavenging functions. The free radical activity assays further confirmed the anti-oxidative potential of some these compounds. The anti-oxidative activity was, nonetheless, similar across sclerites regardless of the health condition of the colony, although sclerites from diseased sea fans display slightly higher anti-oxidative activity than the healthy ones. Sclerites harbor great SVOCs diversity, the majority of which are novel to sea fans or any other corals. Yet the scientific literature consulted showed that the roles of compounds found in sclerites vary from antioxidant to antimicrobial compounds. However, this study fell short in determine the origin of the SVOCs identified, undermining our capacity to determine the biological roles of the SVOCs on sclerites and sea fans.This work was supported by the Puerto Rico Center for Environmental Neuroscience (PRCEN) through an NSF Centers of Research Excellent in Science and Technology (CREST) award, number HRD-1137725

IFE Plant Technology Overview and contribution to HiPER proposal

HiPER is the European Project for Laser Fusion that has been able to join 26 institutions and signed under formal government agreement by 6 countries inside the ESFRI Program of the European Union (EU). The project is already extended by EU for two years more (until 2013) after its first preparatory phase from 2008. A large work has been developed in different areas to arrive to a design of repetitive operation of Laser Fusion Reactor, and decisions are envisioned in the next phase of Technology Development or Risk Reduction for Engineering or Power Plant facilities (or both). Chamber design has been very much completed for Engineering phase and starting of preliminary options for Reactor Power Plant have been established and review here