Global superscaling analysis of quasielastic electron scattering with relativistic effective mass

We present a global analysis of the inclusive quasielastic electron scattering data with a superscaling approach with relativistic effective mass. The SuSAM* model exploits the approximation of factorization of the scaling function $f^*(\psi^*)$ out of the cross section under quasifree conditions. Our approach is based on the relativistic mean field theory of nuclear matter where a relativistic effective mass for the nucleon encodes the dynamics of nucleons moving in presence of scalar and vector potentials. Both the scaling variable $\psi^*$ and the single nucleon cross sections include the effective mass as a parameter to be fitted to the data alongside the Fermi momentum $k_F$. Several methods to extract the scaling function and its uncertainty from the data are proposed and compared. The model predictions for the quasielastic cross section and the theoretical error bands are presented and discussed for nuclei along the periodic table from $A=2$ to $A=238$: $^2$H, $^3$H, $^3$He, $^4$He, $^{12}$C, $^{6}$Li, $^{9}$Be, $^{24}$Mg, $^{59}$Ni, $^{89}$Y, $^{119}$Sn, $^{181}$Ta, $^{186}$W, $^{197}$Au, $^{16}$O, $^{27}$Al, $^{40}$Ca, $^{48}$Ca, $^{56}$Fe, $^{208}$Pb, and $^{238}$U. We find that more than 9000 of the total $\sim 20000$ data fall within the quasielastic theoretical bands. Predictions for $^{48}$Ti and $^{40}$Ar are also provided for the kinematics of interest to neutrino experiments.Comment: 26 pages, 20 figures and 4 table

Growth vs. level effect of population change on economic development: An inspection into human-capital-related mechanisms

This paper studies the different mechanisms and the dynamics through which demography is channelled to the economy. We analyze the role of demographic changes in the economic development process by studying the transitional and the long-run impact of both the rate of population growth and the initial population size on the levels of per capita human capital and income. We do that in an enlarged Lucas-Uzawa model with intergenerational altruism. In contrast to the existing theoretical literature, the long-run level effects of demographic changes, i.e. their impact on the levels of the variables along the balanced growth path, are deeply characterized in addition to the more standard long-run growth effects. We prove that the level effect of the population rate of growth is non-negative (positive in the empirically most relevant case) for the average level of human capital, but a priori ambiguous for the level of per capita income due to the interaction of three transmission mechanisms of demographic shocks, a standard one (dilution) and two non-standard (altruism and human capital accumulation). Overall, the sign of the level effects of population growth depend on preference and technology parameters, but numerically we show that the joint negative effect of dilution and altruism is always stronger than the finduced positive human capital effect. The growth effect of population growth depends basically on the attitude to intergenerational altruism and intertemporal substitution. Moreover, we also prove that the long-run level effects of population size on per capita human capital and income may be negative, nil, or positive, depending on the relationship between preferences and technology, while its growth effect is zero. Finally, we show that the model is able to replicate complicated time relationships between economic and demographic changes. In particular, it entails a negative effect of population growth on per capita income, which dominates in the initial periods, and a positive effect which restores a positive correlation between population growth and economic performance in the long term.Human Capital, Population Growth, Population Size, Endogenous Growth, Level Effect, Growth Effect

Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection

Although antiviral agents which block human immunodeficiency virus (HIV) replication can result in long-term suppression of viral loads to undetectable levels in plasma, long-term therapy fails to eradicate virus, which generally rebounds after a single treatment interruption. Multiple structured treatment interruptions (STIs) have been suggested as a possible strategy that may boost HIV-specific immune responses and control viral replication. We analyze viral dynamics during four consecutive STI cycles in 12 chronically infected patients with a history (>2 years) of viral suppression under highly active antiretroviral therapy. We fitted a simple model of viral rebound to the viral load data from each patient by using a novel statistical approach that allows us to overcome problems of estimating viral dynamics parameters when there are many viral load measurements below the limit of detection. There is an approximate halving of the average viral growth rate between the first and fourth STI cycles, yet the average time between treatment interruption and detection of viral loads in the plasma is approximately the same in the first and fourth interruptions. We hypothesize that reseeding of viral reservoirs during treatment interruptions can account for this discrepancy, although factors such as stochastic effects and the strength of HIV-specific immune responses may also affect the time to viral rebound. We also demonstrate spontaneous drops in viral load in later STIs, which reflect fluctuations in the rates of viral production and/or clearance that may be caused by a complex interaction between virus and target cells and/or immune responses

Optical absorption of divalent metal tungstates: Correlation between the band-gap energy and the cation ionic radius

We have carried out optical-absorption and reflectance measurements at room temperature in single crystals of AWO4 tungstates (A = Ba, Ca, Cd, Cu, Pb, Sr, and Zn). From the experimental results their band-gap energy has been determined to be 5.26 eV (BaWO4), 5.08 eV (SrWO4), 4.94 eV (CaWO4), 4.15 eV (CdWO4), 3.9-4.4 eV (ZnWO4), 3.8-4.2 eV (PbWO4), and 2.3 eV (CuWO4). The results are discussed in terms of the electronic structure of the studied tungstates. It has been found that those compounds where only the s electron states of the A2+ cation hybridize with the O 2p and W 5d states (e.g BaWO4) have larger band-gap energies than those where also p, d, and f states of the A2+ cation contribute to the top of the valence band and the bottom of the conduction band (e.g. PbWO4). The results are of importance in view of the large discrepancies existent in prevoiusly published data.Comment: 16 pages, 3 figures, 1 tabl

Irregular self-similar configurations of shock-wave impingement on shear layers

An oblique shock impinging on a shear layer that separates two uniform supersonic streams, of Mach numbers M1 and M2, at an incident angle σi can produce regular and irregular interactions with the interface. The region of existence of regular shock refractions with stable flow structures is delineated in the parametric space (M1,M2,σi) considering oblique-shock impingement on a supersonic vortex sheet of infinitesimal thickness. It is found that under supercritical conditions, the oblique shock fails to deflect both streams consistently and to provide balanced flow properties downstream. In this circumstance, the flow renders irregular configurations which, in the absence of characteristic length scales, exhibit self-similar pseudosteady behaviours. These cases involve shocks moving upstream at constant speed and increasing their intensity to comply with equilibrium requirements. Differences in the variation of propagation speed among the flows yield pseudosteady configurations that grow linearly with time. Supercritical conditions are described theoretically and reproduced numerically using highly resolved inviscid simulation

Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1

Increased susceptibility to the protease inhibitors saquinavir and amprenavir has been observed in human immunodeficiency virus type 1 (HIV-1) with specific mutations in protease (V82T and N88S). Increased susceptibility to ritonavir has also been described in some viruses from antiretroviral agent-naïve patients with primary HIV-1 infection in association with combinations of amino acid changes at polymorphic sites in the protease. Many of the viruses displaying increased susceptibility to protease inhibitors also had low replication capacity. In this retrospective study, we analyze the drug susceptibility phenotype and the replication capacity of virus isolates obtained at the peaks of viremia during five consecutive structured treatment interruptions in 12 chronically HIV-1-infected patients. Ten out of 12 patients had at least one sample with protease inhibitor hypersusceptibility (change ≤0.4-fold) to one or more protease inhibitor. Hypersusceptibility to different protease inhibitors was observed at variable frequency, ranging from 38% to amprenavir to 11% to nelfinavir. Pairwise comparisons between susceptibilities for the protease inhibitors showed a consistent correlation among all pairs. There was also a significant relationship between susceptibility to protease inhibitors and replication capacity in all patients. Replication capacity remained stable over the course of repetitive cycles of structured treatment interruptions. We could find no association between in vitro replication capacity and in vivo plasma viral load doubling time and CD4(+) and CD8(+) T-cell counts at each treatment interruption. Several mutations were associated with hypersusceptibility to each protease inhibitor in a univariate analysis. This study extends the association between hypersusceptibility to protease inhibitors and low replication capacity to virus isolated from chronically infected patients and highlights the complexity of determining the genetic basis of this phenomenon. The potential clinical relevance of protease inhibitor hypersusceptibility and low replication capacity to virologic response to protease inhibitor-based therapies deserves to be investigated further

Analysis of CMB maps with 2D wavelets

We consider the 2D wavelet transform with two scales to study sky maps of temperature anisotropies in the cosmic microwave background radiation (CMB). We apply this technique to simulated maps of small sky patches of size 12.8 \times 12.8 square degrees and 1.5' \times 1.5' pixels. The relation to the standard approach, based on the cl's is established through the introduction of the scalogram. We consider temperature fluctuations derived from standard, open and flat-Lambda CDM models. We analyze CMB anisotropies maps plus uncorrelated Gaussian noise (uniform and non-uniform) at idfferent S/N levels. We explore in detail the denoising of such maps and compare the results with other techniques already proposed in the literature. Wavelet methods provide a good reconstruction of the image and power spectrum. Moreover, they are faster than previously proposed methods.Comment: latex file 7 pages + 5 postscript files + 1 gif file; accepted for publication in A&A

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis.

Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and stimulates ceramide synthesis. Here we investigated the synergism between MA and PA in ceramide synthesis, ER stress, lipotoxicity and NASH. Unlike PA, MA is not lipotoxic but potentiated PA-mediated lipoapoptosis, ER stress, caspase-3 activation and cytochrome c release in primary mouse hepatocytes (PMH). Moreover, MA kinetically sustained PA-induced total ceramide content by stimulating dehydroceramide desaturase and switched the ceramide profile from decreased to increased ceramide 14:0/ceramide16:0, without changing medium and long-chain ceramide species. PMH were more sensitive to equimolar ceramide14:0/ceramide16:0 exposure, which mimics the outcome of PA plus MA treatment on ceramide homeostasis, than to either ceramide alone. Treatment with myriocin to inhibit ceramide synthesis and tauroursodeoxycholic acid to prevent ER stress ameliorated PA plus MA induced apoptosis, similar to the protection afforded by the antioxidant BHA, the pan-caspase inhibitor z-VAD-Fmk and JNK inhibition. Moreover, ruthenium red protected PMH against PA and MA-induced cell death. Recapitulating in vitro findings, mice fed a diet enriched in PA plus MA exhibited lipodystrophy, hepatosplenomegaly, increased liver ceramide content and cholesterol levels, ER stress, liver damage, inflammation and fibrosis compared to mice fed diets enriched in PA or MA alone. The deleterious effects of PA plus MA-enriched diet were largely prevented by in vivo myriocin treatment. These findings indicate a causal link between ceramide synthesis and ER stress in lipotoxicity, and imply that the consumption of diets enriched in MA and PA can cause NASH associated with lipodystrophy

Splitting of the middle layer of LPW SAFNWC/MSG satellite product in order to improve the monitoring of pre-convective environments

International audienceSeven of the infrared channels from the Spinning Enhanced Visible and Infrared Imagery (SEVIRI) instrument, on board the Meteosat Second Generation (MSG), are used to retrieve Layer Precipitable Water (LPW) and Stability Analysis Imagery (SAI) in the SAFNWC framework. Both products are retrieved using a statistical retrieval based on neural networks; they are routinely generated every fifteen minutes at a satellite horizontal resolution of 3 km in NADIR only in cloud-free areas. Many factors are involved in the development of severe weather and these parameters are only some of the indicators. However, due to the high resolution of these products, the use of them in conjunction with satellite and radar images can help to identify mesoscale features related to convection. The MSG moisture and parcel instability time trend fields are especially useful during the period previous to convection. Once the outbreak of convection occurs, the products calculated in the clear air pixels surrounding the convective system can give us hints to anticipate its evolution. SAFNWC LPW and SAI were analyzed for a severe weather event during August 2004. A thunderstorm over Teruel (Spain) produced intense precipitation and hail; a tornado developed while this thunderstorm was moving towards SE. The pre-convective parcel potential buoyancy and moisture SAFNWC products changed in a way that was consistent with the observed intense convective activity. In previous studies, the atmospheric moisture in medium levels, which has been proven to be relevant in some cases, was represented by only one level parameter (ML: middle layer LPW). However, it was observed that this layer is too thick to do an adequate analysis of moisture available for convection. Hence, an improvement on the LPW algorithm has been carried out by splitting the middle layer into two new sub-layers (approximately separated at 700 hPa) and training two new neural networks. The impact of monitoring moisture in the new sub-layers separately in this severe weather event has been tested, and the improvements achieved have been evaluated