88 research outputs found
True vertical validation in facial orthognathic surgery planning
Objectives: To validate the effectiveness of the original standards of True Vertical (TV) Subnasal Line in orthognatic
surgery planning. The present study evaluates the changes occurring in patients with skeletal Class II alterations
programmed for orthognathic surgery with a view to improving their facial profile.
Study desing: We showed a series of black profiles (composed by a first control group of subjects with normal occlusion,
and another two additional groups comprised patients before -Group 2- and after orthognatic surgical correction
of Class II malocclusion -Group 3-) for three groups of observers (orthodontists, surgeons and laypeople).
The facial images became black silhouettes in order to determine a series of parameters (including aesthetic assessment)
by means of the observers. Their observation were assessed using a 5-point Likert scale.
Results: The sample was composed of 52 profile's subjects who were tested for a total of 72 observers. Aesthetic
assessment yielded mean scores of 2.57, 1.67 and 2.46 for groups 1, 2 and 3, respectively. There was a statistically
significant difference (p<0.001) between group 1 versus group 2. There were no significant differences in terms
of observer assessment of aesthetics, with the exception of a wider perception range among the orthodontists. Regarding
the studied profile measures, significant differences were recorded for point B' and Pg' (p<0.02) between
groups 2 and 3 (i.e., pre- versus post-surgery).
Conclusions: The results of our study suggest the subnasale vertical and sagittal measures of the lower third of the
face are decisive in facial aesthetics, and therefore also for the planning of orthognathic surgery. Consequently,
these aesthetic parameters can be used as an objective tool for the planning of orthodontic treatment
Lower incisor position in different malocclusions and facial patterns
Introduction: The position of lower incisor has been of considerable concern when planning an orthodontic treatment, having been recognized as one of diagnostic keys, Very important in the development of malocclusion and
facial pattern.
Objectives: In this study we claim to determine the importance of the position and inclination of lower incisor in
the different malocclusions and facial patterns, and to base which of the cephalometric measurement parameters
are the mostreliable.
Material and Methods: Ninety lateral radiographies were taken, and they were classified by skeletal malocclusion
and facial pattern.These teleradiographies have been performed cephalometric analysis, which includelower incisor position belong the following analysis: Ricketts, Riolo, Tweed, McHorris, Jarabak-MSE and Holdaway.
Study
Design: Cross-sectional study where we perform statistical analysis Anova test, Pearson correlations and
Bonferroni analysis.
Results: The analyzed measurements present a statistically significant differentiation in lower incisor inclination
respect to the anterior cranial base, McHorris angle, angulation of lower incisor respect to occlusal plane and
mandibular plane.
Conclusions: There are statistically significant differentiation in lower incisor position and inclination respect the
malocclusion and individual facial pattern
Lower incisor position in different malocclusions and facial patter
Introduction: The position of lower incisor has been of considerable concern when planning an orthodontic treatment, having been recognized as one of diagnostic keys, Very important in the development of malocclusion and facial pattern.
Objectives: In this study we claim to determine the importance of the position and inclination of lower incisor in the different malocclusions and facial patterns, and to base which of the cephalometric measurement parameters are the mostreliable.
Material and Methods: Ninety lateral radiographies were taken, and they were classified by skeletal malocclusion and facial pattern.These teleradiographies have been performed cephalometric analysis, which includelower incisor position belong the following analysis: Ricketts, Riolo, Tweed, McHorris, Jarabak-MSE and Holdaway.
Study Design: Cross-sectional study where we perform statistical analysis Anova test, Pearson correlations and Bonferroni analysis.
Results: The analyzed measurements present a statistically significant differentiation in lower incisor inclination
respect to the anterior cranial base, McHorris angle, angulation of lower incisor respect to occlusal plane and
mandibular plane.
Conclusions: There are statistically significant differentiation in lower incisor position and inclination respect the malocclusion and individual facial pattern
Overoxidation of chloroplast 2-Cys peroxiredoxins: balancing toxic and signaling activities of hydrogen peroxide
Photosynthesis, the primary source of biomass and oxygen into the biosphere, involves the transport of electrons in the presence of oxygen and, therefore, chloroplasts constitute an important source of reactive oxygen species, including hydrogen peroxide. If accumulated at high level, hydrogen peroxide may exert a toxic effect; however, it is as well an important second messenger. In order to balance the toxic and signaling activities of hydrogen peroxide its level has to be tightly controlled. To this end, chloroplasts are equipped with different antioxidant systems such as 2-Cys peroxiredoxins (2-Cys Prxs), thiol-based peroxidases able to reduce hydrogen and organic peroxides. At high peroxide concentrations the peroxidase function of 2-Cys Prxs may become inactivated through a process of overoxidation. This inactivation has been proposed to explain the signaling function of hydrogen peroxide in eukaryotes, whereas in prokaryotes, the 2-Cys Prxs of which were considered to be insensitive to overoxidation, the signaling activity of hydrogen peroxide is less relevant. Here we discuss the current knowledge about the mechanisms controlling 2-Cys Prx overoxidation in chloroplasts, organelles with an important signaling function in plants. Given the prokaryotic origin of chloroplasts, we discuss the occurrence of 2-Cys Prx overoxidation in cyanobacteria with the aim of identifying similarities between chloroplasts and their ancestors regarding their response to hydrogen peroxide.España , Ministerio de Ciencia e Innovación BIO2010-15430España, Junta de Andalucía BIO-182España, Junta de Andalucía CVI-591
Innovative compounds to battle multirresistance to antibiotics: use of pva-tannic acid nano- particles to inhibit staphylococcus pseudintermedius growth
Antibiotic resistance is an increasing public health problem that affects to numerous
pathogens, including Staphylococcus pseudintermedius, which has a high prevalence
of methicillin resistance and can be transmitted to humans.
The development of new compounds to prevent the appearance of antibiotic
resistances and find alternatives to classic therapies is essential to health protection.
The main objective of the present study is to determine whether the nanoparticles of
polyvinyl alcohol and tannic acid “PVA-TA NPs” are effective to inhibit Staphylococcus
pseudintermedius and can be considered as an alternative therapy.
The study includes increasing concentration essays of the nanoparticles and
establishes, using the determination of turbidity by refractometry that could be a
useful tool to inhibit bacterial growth, resulting successful.
Nonetheless, further studies to identify the underlying action mechanisms of these
nano-particles are going on in our group
Looking for new compounds to battle antibiotic resistance: optimization of organic solvents
A high number of pathogens have shown the capacity of resist to the action of
antibiotics. This fact presents a very important problem to public health and highlights
the necessity of looking for new substances as alternative to antibiotics.
Since some of these substances have a hydrophobic nature they need to be solved in
organic solvents. Some of these solvents are also toxic to bacteria, mainly affecting
membranes. For these reasons it is necessary to perform a study of the toxicity of
organic solvents to bacteria, which has been the aim of this work.
Five organic solvents, DMF (dimethylformamide), TBME (tert-butyl methyl ether),
THF (tetrahydrofuran), DMSO (dimethyl sulfoxide) and CH2Cl2 (dichloromethane),
have been tested, using two of the most prevalent pathogens (Staphylococcus
pseudintermedius and Pseudomonas aeruginosa,) both in animals and humans.
The results show that, when possible, DMSO followed by TBME are the best options
for testing new compounds in Staphylococcus pseudintermedius, whether DMF
followed by TBME are the preferred solvents for testing hydrophobic compounds in
Pseudomonas aeruginosa
Biofortificación de plantas de medicago sativa mediante el uso de nanoparticulas cargadas con hierro
El concepto de biofortificación se basa en incrementar el valor nutricional de los
diferentes alimentos por medio de métodos de selección, mejora de cultivos
o ingeniería genética. En este sentido, el trabajo que presentamos ha utilizado
nanopartículas cargadas con hierro como parte de la disolución de riego, con el
objeto de evaluar cómo se incorpora este elemento en plantas de cultivo destinadas
a la alimentación animal. En este trabajo se empleó como planta experimental
la especie Medicago sativa, cuyo nombre común es alfalfa y suele usarse como
alimento de forrajeo para los animales de granja. Los experimentos mostraron que
las nanopartículas tenían efectos muy positivos sobre el crecimiento y se observaba
un aumento importante en la concentración de la clorofila de la propia planta
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