War and Economics: Spanish Civil War Finances Revisited

This paper reviews how the Spanish civil war was financed. We present new evidence to show that the two combatant parties, the Republican government and the Franco administration followed similar financial strategies. In both cases money creation, rather than new taxes or the issue of debt, was the main mechanism used to cover the expenses of the war. We argue, contrary to the established knowledge, that both sides consumed a similar amount of domestic and foreign resources. We also argue that the Spanish Republic did not lose the war because of a lack of means. International factors, such as the Non-Intervention agreement promoted by France and Great Britain, and the military setbacks of the Republican army during the first year of the war, were decisive for Franco’s victory in 1939.Spain, civil war, financial resources

Optical absorption of divalent metal tungstates: Correlation between the band-gap energy and the cation ionic radius

We have carried out optical-absorption and reflectance measurements at room temperature in single crystals of AWO4 tungstates (A = Ba, Ca, Cd, Cu, Pb, Sr, and Zn). From the experimental results their band-gap energy has been determined to be 5.26 eV (BaWO4), 5.08 eV (SrWO4), 4.94 eV (CaWO4), 4.15 eV (CdWO4), 3.9-4.4 eV (ZnWO4), 3.8-4.2 eV (PbWO4), and 2.3 eV (CuWO4). The results are discussed in terms of the electronic structure of the studied tungstates. It has been found that those compounds where only the s electron states of the A2+ cation hybridize with the O 2p and W 5d states (e.g BaWO4) have larger band-gap energies than those where also p, d, and f states of the A2+ cation contribute to the top of the valence band and the bottom of the conduction band (e.g. PbWO4). The results are of importance in view of the large discrepancies existent in prevoiusly published data.Comment: 16 pages, 3 figures, 1 tabl

Electromagnetic dipole moments of charged baryons with bent crystals at the LHC

We propose a unique program of measurements of electric and magnetic dipole moments of charm, beauty and strange charged baryons at the LHC, based on the phenomenon of spin precession of channeled particles in bent crystals. Studies of crystal channeling and spin precession of positively- and negatively-charged particles are presented, along with feasibility studies and expected sensitivities for the proposed experiment using a layout based on the LHCb detector.Comment: 19 pages, 13 figure

Splitting of the middle layer of LPW SAFNWC/MSG satellite product in order to improve the monitoring of pre-convective environments

International audienceSeven of the infrared channels from the Spinning Enhanced Visible and Infrared Imagery (SEVIRI) instrument, on board the Meteosat Second Generation (MSG), are used to retrieve Layer Precipitable Water (LPW) and Stability Analysis Imagery (SAI) in the SAFNWC framework. Both products are retrieved using a statistical retrieval based on neural networks; they are routinely generated every fifteen minutes at a satellite horizontal resolution of 3 km in NADIR only in cloud-free areas. Many factors are involved in the development of severe weather and these parameters are only some of the indicators. However, due to the high resolution of these products, the use of them in conjunction with satellite and radar images can help to identify mesoscale features related to convection. The MSG moisture and parcel instability time trend fields are especially useful during the period previous to convection. Once the outbreak of convection occurs, the products calculated in the clear air pixels surrounding the convective system can give us hints to anticipate its evolution. SAFNWC LPW and SAI were analyzed for a severe weather event during August 2004. A thunderstorm over Teruel (Spain) produced intense precipitation and hail; a tornado developed while this thunderstorm was moving towards SE. The pre-convective parcel potential buoyancy and moisture SAFNWC products changed in a way that was consistent with the observed intense convective activity. In previous studies, the atmospheric moisture in medium levels, which has been proven to be relevant in some cases, was represented by only one level parameter (ML: middle layer LPW). However, it was observed that this layer is too thick to do an adequate analysis of moisture available for convection. Hence, an improvement on the LPW algorithm has been carried out by splitting the middle layer into two new sub-layers (approximately separated at 700 hPa) and training two new neural networks. The impact of monitoring moisture in the new sub-layers separately in this severe weather event has been tested, and the improvements achieved have been evaluated

Analysis of CMB maps with 2D wavelets

We consider the 2D wavelet transform with two scales to study sky maps of temperature anisotropies in the cosmic microwave background radiation (CMB). We apply this technique to simulated maps of small sky patches of size 12.8 \times 12.8 square degrees and 1.5' \times 1.5' pixels. The relation to the standard approach, based on the cl's is established through the introduction of the scalogram. We consider temperature fluctuations derived from standard, open and flat-Lambda CDM models. We analyze CMB anisotropies maps plus uncorrelated Gaussian noise (uniform and non-uniform) at idfferent S/N levels. We explore in detail the denoising of such maps and compare the results with other techniques already proposed in the literature. Wavelet methods provide a good reconstruction of the image and power spectrum. Moreover, they are faster than previously proposed methods.Comment: latex file 7 pages + 5 postscript files + 1 gif file; accepted for publication in A&A

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis.

Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and stimulates ceramide synthesis. Here we investigated the synergism between MA and PA in ceramide synthesis, ER stress, lipotoxicity and NASH. Unlike PA, MA is not lipotoxic but potentiated PA-mediated lipoapoptosis, ER stress, caspase-3 activation and cytochrome c release in primary mouse hepatocytes (PMH). Moreover, MA kinetically sustained PA-induced total ceramide content by stimulating dehydroceramide desaturase and switched the ceramide profile from decreased to increased ceramide 14:0/ceramide16:0, without changing medium and long-chain ceramide species. PMH were more sensitive to equimolar ceramide14:0/ceramide16:0 exposure, which mimics the outcome of PA plus MA treatment on ceramide homeostasis, than to either ceramide alone. Treatment with myriocin to inhibit ceramide synthesis and tauroursodeoxycholic acid to prevent ER stress ameliorated PA plus MA induced apoptosis, similar to the protection afforded by the antioxidant BHA, the pan-caspase inhibitor z-VAD-Fmk and JNK inhibition. Moreover, ruthenium red protected PMH against PA and MA-induced cell death. Recapitulating in vitro findings, mice fed a diet enriched in PA plus MA exhibited lipodystrophy, hepatosplenomegaly, increased liver ceramide content and cholesterol levels, ER stress, liver damage, inflammation and fibrosis compared to mice fed diets enriched in PA or MA alone. The deleterious effects of PA plus MA-enriched diet were largely prevented by in vivo myriocin treatment. These findings indicate a causal link between ceramide synthesis and ER stress in lipotoxicity, and imply that the consumption of diets enriched in MA and PA can cause NASH associated with lipodystrophy

Search for new physics via baryon EDM at LHC

Permanent electric dipole moments (EDMs) of fundamental particles provide powerful probes for physics beyond the Standard Model. We propose to search for the EDM of strange and charm baryons at LHC, extending the ongoing experimental program on the neutron, muon, atoms, molecules and light nuclei. The EDM of strange $\Lambda$ baryons, selected from weak decays of charm baryons produced in pp collisions at LHC, can be determined by studying the spin precession in the magnetic field of the detector tracking system. A test of CPT symmetry can be performed by measuring the magnetic dipole moment of $\Lambda$ and $\overline{\Lambda}$ baryons. For short-lived $\Lambda_c^+$ and $\Xi_c^+$ baryons, to be produced in a fixed-target experiment using the 7 TeV LHC beam and channeled in a bent crystal, the spin precession is induced by the intense electromagnetic field between crystal atomic planes. The experimental layout based on the LHCb detector and the expected sensitivities in the coming years are discussed.Comment: Proceeding of Lepton Photon Interactions at High Energies (2017

Impact of Midodrine on Optimization of β-blocker Therapy in Patients with Heart Failure with Reduced Ejection Fraction

Introduction: Midodrine, an α-adrenergic agonist approved for orthostatic hypotension, is used off-label for hypotension in patients with heart failure with reduced ejection fraction (HFrEF). However, its prevalence, clinical outcomes, and risks in HFrEF remain unclear. Theoretically, adding midodrine to HFrEF patients’ medication regimens may facilitate up-titration of guideline-directed medical therapy (GDMT) by attenuating its corresponding hypotensive effects. This study aims to assess the concurrent use of midodrine and β-blockers in patients with HFrEF to allow the initiation or up-titration of GDMT. Methods: This was a multisite, retrospective chart review of adult patients with HFrEF who received concomitant treatment with midodrine and a β-blocker from March to June 2022. Patients were excluded if they were pregnant, had a left ventricular ejection fraction (LVEF) ≥ 50%, or received concomitant therapy for less than 48 hours. Primary outcomes included tolerance of β-blocker initiation and up-titration with midodrine. Secondary outcomes included initiation and continuation of midodrine and β-blockers or additional GDMT upon discharge. Results: Twenty-six patients were included. All patients on midodrine were initiated on β-blockers, and 73% (n = 19) tolerated β-blocker dose titration. An improvement in mean systolic blood pressure (SBP) from 104 mmHg to 112 mmHg was observed. Nineteen (73%) patients were discharged on midodrine and β-blockers, while 7 (27%) patients were discharged on β-blockers alone. Discussion: The initiation of midodrine improved mean SBP and enhanced tolerability of β-blockers in HFrEF patients. Further studies with larger sample sizes are necessary to evaluate midodrine\u27s long-term risks and benefits in HFrEF