An instrument for dimensional diagnosis of a child’s constitution (ICC)

Developmental disorders present themselves with complex problems that may threaten a child’s development. In every child a disorder shows itself in a unique way, which makes it necessary to individualize. The objective of this preliminary study is to develop an instrument that provides a dimensional diagnosis by mapping the degree of (dis)balance in three domains of child development. The instrument is based on anthroposophic anthropology and typology. The instrument will be usable in all kinds of care for children with developmental disorders.The typology of a child’s constitution was operationalized using concept mapping and consensus building with experts. Preliminary tests of the psychometric properties of the instrument were applied on children with developmental disorders in a pilot study in Dutch healthcare. The Instrument for diagnosis of a Child’s Constitution (ICC) developed in this study consists of two parts. Part I contains 36 polar formulated items in three subscales of 12 items and is to be completed by healthcare professionals. Part II consists of three VAS scales (Visual analogue scales) and is to be completed y a practitioner. The outcome (the scores of Part I and II) forms a profile of the child’s constitution, showing the (dis) balance in three domains of child development. A pilot study with 38 children shows positive face validity, and moderate internal consistency and inter-rater reliability of the ICC. The ICC has been developed as a diagnostic instrument to assess individualized dimensional diagnosis of children with a developmental disorder. Future studies will focus on validation of the instrument

Effects of an Intervention Program on Interaction and Communication in Adults with Congenital Deafblindness and an Intellectual Disability

Interaction with people with congenital deafblindness (CDB) and an intellectual disability (ID), and recognition of their often unconventional expressions, is complex. In this study, the effects of a two-phase intervention program intended to foster harmonious interaction and the use and recognition of expressions based on a bodily emotional trace (BET) were examined. Five adults with CDB and an ID, and ten of their caregivers participated in the study. A multiple-baseline design was used. Target behaviours were attention by caregiver, attention by participant, confirmation by caregiver, mutual affective involvement, quality of interaction, participant expressions based on a BET, and participant expressions based on a BET recognised by the caregiver. Overall, the results tend to be positive. However, some of the changes were minimal and the results varied considerably among participants. The results of this study suggest that it is possible to foster harmonious interaction and the use and recognition of expressions based on a BET in adults with CDB and an ID

Improved p-hydroxybenzoate production by engineered Pseudomonas putida S12 by using a mixed-substrate feeding strategy

The key precursors for p-hydroxybenzoate production by engineered Pseudomonas putida S12 are phosphoenolpyruvate (PEP) and erythrose-4-phosphate (E4P), for which the pentose phosphate (PP) pathway is an important source. Since PP pathway fluxes are typically low in pseudomonads, E4P and PEP availability is a likely bottleneck for aromatics production which may be alleviated by stimulating PP pathway fluxes via co-feeding of pentoses in addition to glucose or glycerol. As P. putida S12 lacks the natural ability to utilize xylose, the xylose isomerase pathway from E. coli was introduced into the p-hydroxybenzoate producing strain P. putida S12palB2. The initially inefficient xylose utilization was improved by evolutionary selection after which the p-hydroxybenzoate production was evaluated. Even without xylose-co-feeding, p-hydroxybenzoate production was improved in the evolved xylose-utilizing strain, which may indicate an intrinsically elevated PP pathway activity. Xylose co-feeding further improved the p-hydroxybenzoate yield when co-fed with either glucose or glycerol, up to 16.3 Cmol% (0.1 g p-hydroxybenzoate/g substrate). The yield improvements were most pronounced with glycerol, which probably related to the availability of the PEP precursor glyceraldehyde-3-phosphate (GAP). Thus, it was demonstrated that the production of aromatics such as p-hydroxybenzoate can be improved by co-feeding different carbon sources via different and partially artificial pathways. Moreover, this approach opens new perspectives for the efficient production of (fine) chemicals from renewable feedstocks such as lignocellulose that typically has a high content of both glucose and xylose and (crude) glycerol

An instrument for dimensional diagnosis of a child’s constitution (ICC)

Developmental disorders present themselves with complex problems that may threaten a child’s development. In every child a disorder shows itself in a unique way, which makes it necessary to individualize. The objective of this preliminary study is to develop an instrument that provides a dimensional diagnosis by mapping the degree of (dis)balance in three domains of child development. The instrument is based on anthroposophic anthropology and typology. The instrument will be usable in all kinds of care for children with developmental disorders.The typology of a child’s constitution was operationalized using concept mapping and consensus building with experts. Preliminary tests of the psychometric properties of the instrument were applied on children with developmental disorders in a pilot study in Dutch healthcare. The Instrument for diagnosis of a Child’s Constitution (ICC) developed in this study consists of two parts. Part I contains 36 polar formulated items in three subscales of 12 items and is to be completed by healthcare professionals. Part II consists of three VAS scales (Visual analogue scales) and is to be completed y a practitioner. The outcome (the scores of Part I and II) forms a profile of the child’s constitution, showing the (dis) balance in three domains of child development. A pilot study with 38 children shows positive face validity, and moderate internal consistency and inter-rater reliability of the ICC. The ICC has been developed as a diagnostic instrument to assess individualized dimensional diagnosis of children with a developmental disorder. Future studies will focus on validation of the instrument

Accommodating the Bayley-III for motor and/or visual impairment:A comparative pilot study

PURPOSE: This study assessed the validity and usefulness of the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) Low Motor/Vision accommodated version. Accommodations are adaptations to minimize impairment bias, without altering what the test measures. Of the items, 66% have Low Motor accommodations like enlarged materials; 62% have Low Vision accommodations. METHODS: Using a within-subject design, we tested 19 children with the accommodated and standard Bayley-III, in a randomly counterbalanced order. The children had motor and/or visual impairment and a chronological age between 22 and 90 months. The test administrators completed an evaluation form. RESULTS: A subgroup of children benefited from the accommodations; 2 children obtained a large raw score difference. Test administrators considered the accommodations as practical, and advantageous for most children. CONCLUSION: The Low Motor/Vision accommodated version seems to validly assess the development of this population. Future, larger-scale research should study whether the accommodations improve the construct validity of the Bayley-III