The Development and Application of Crop Evaluation System Based on GRA

Ever since it was proposed, grey system theory has attracted the attention of scientific researchers and scholars. And it also has been widely used in many fields and solved a large number of practical problems in production, life, and scientific research. With the development and popularization of computer science and network technology, this traditional mathematical model can be applied more simply and efficiently to solve practical problems. Firstly, this paper, to implement steps of grey relational analysis, has made the exclusive analysis and has made the simple introduction to grey relational analysis characteristics. Then, based on grey relational theory and ASP.NET technology, the crop evaluation system is developed. Lastly, by using Excel and the crop evaluation system, the paper carries out a comprehensive evaluation about eight features of Fuji apple, which is from nine different producing areas, respectively. The experiment results show that the crop evaluation system is effective and could greatly improve the work efficiency of the researcher and expand the application scope

Update on poly(ADP-ribose) polymerase inhibitors resistance in ovarian cancer

Ovarian cancer is one of the most common reproductive system tumors. The incidence of ovarian cancer in China is on the rise. Poly(ADP-ribose) polymerase (PARP) inhibitor (PARPi) is a DNA repair enzyme associated with DNA damage repair. PARPi takes PARP as a target to kill tumor cells, especially for tumors with homologous recombination (HR) dysfunction. Currently, PARPi has been widely used in clinical practice, mainly for the maintenance of advanced ovarian epithelial cancer. The intrinsic or acquired drug resistance of PARPi has gradually become an important clinical problem with the wide application of PARPi. This review summarizes the mechanisms of PARPi resistance and the current progress on PARPi-based combination strategies

Research Progress in Anaerobic Digestion of High Moisture

High moisture organic waste constitutes a large fraction of municipal solid waste and caused a nuisance. Anaerobic digestion of this high degradable fraction has been developed during the past 20 years. Parameters such as characteristic of substrates, temperature, organic loading rate and hydraulic retention time were studied. The most important conversion of intermediate of volatile fatty acid was observed as a indicator of digestion efficiency. One stage and two stage system are based on the stage separated into acidogenic phase and methnogenis phase. Two stage digestion of this kind of wastes were proved a better efficiency than single stage digestion. Batch system and continuous system are conducted in single stage and two-stage system. One stage system are split between wet system(Total solid less than 15%) and dry system( total solid higher than 15%) according to the characteristics of feedstock. Two-stage solid bed system are observed more and more popular in the digestion of solid state VFW and food waste experimental studies, however the large majority of industrial application use single stage systems. Two stage digestion of HMOW will be applied to industrial scale due to its larger resistance to high loading rate, high and stable gas production

A Peer-to-peer Federated Continual Learning Network for Improving CT Imaging from Multiple Institutions

Deep learning techniques have been widely used in computed tomography (CT) but require large data sets to train networks. Moreover, data sharing among multiple institutions is limited due to data privacy constraints, which hinders the development of high-performance DL-based CT imaging models from multi-institutional collaborations. Federated learning (FL) strategy is an alternative way to train the models without centralizing data from multi-institutions. In this work, we propose a novel peer-to-peer federated continual learning strategy to improve low-dose CT imaging performance from multiple institutions. The newly proposed method is called peer-to-peer continual FL with intermediate controllers, i.e., icP2P-FL. Specifically, different from the conventional FL model, the proposed icP2P-FL does not require a central server that coordinates training information for a global model. In the proposed icP2P-FL method, the peer-to-peer federated continual learning is introduced wherein the DL-based model is continually trained one client after another via model transferring and inter institutional parameter sharing due to the common characteristics of CT data among the clients. Furthermore, an intermediate controller is developed to make the overall training more flexible. Numerous experiments were conducted on the AAPM low-dose CT Grand Challenge dataset and local datasets, and the experimental results showed that the proposed icP2P-FL method outperforms the other comparative methods both qualitatively and quantitatively, and reaches an accuracy similar to a model trained with pooling data from all the institutions

Homozygous p.Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine.

SLC10A1 codes for the sodium-taurocholate cotransporting polypeptide (NTCP), which is a hepatocellular transporter for bile acids (BAs) and the receptor for hepatitis B and D viruses. NTCP is also a target of multiple drugs. We aimed to evaluate the medical consequences of the loss of function mutation p.Ser267Phe in SLC10A1. We identified eight individuals with homozygous p.Ser267Phe mutation in SLC10A1 and followed up for 8-90 months. We compared their total serum BAs and 6 species of BAs with 170 wild-type and 107 heterozygous healthy individuals. We performed in-depth medical examinations and exome sequencing in the homozygous individuals. All homozygous individuals had persistent hypercholanemia (P = 5.8 × 10-29). Exome sequencing excluded the involvement of other BA metabolism-associated genes in the hypercholanemia. Although asymptomatic, all individuals had low vitamin D levels. Of six adults that were subjected to bone mineral density analysis, three presented with osteoporosis/osteopenia. Sex hormones and blood lipids were deviated in all subjects. Homozygosity of p.Ser267Phe in SLC10A1 is associated with asymptomatic hypercholanemia. Individuals with homozygous p.Ser267Phe in SLC10A1 are prone to vitamin D deficiency, deviated sex hormones and blood lipids. Surveillance of these parameters may also be needed in patients treated with drugs targeting NTCP.This project is supported by the National Natural Science Foundation of China (31471193, 81570539, 81370535, 91331204 and 31525014). S.X. acknowledges financial support from the Strategic Priority Research Program (XDB13040100) and Key Research Program of Frontier Sciences (QYZDJ-SSW-SYS009) of the Chinese Academy of Sciences (CAS)

Qishen Yiqi dripping pills for chronic ischaemic heart failure:results of the CACT-IHF randomized clinical trial

10.1002/ehf2.12980ESC Heart Failure763881-389

Grain size effect on piezoelectric properties of Sr2Nb2O7 ceramics

Grain size effect on piezoelectric properties and thermal stability of perovskite layer structured (PLS) Sr2Nb2O7 ceramics are investigated. The Sr2Nb2O7 ceramics with different average grain sizes from 1.2μm to 3.6μm were prepared in different sintering temperatures by solid state reaction method. The average grain size increases, accompanied by a higher relative density of up to 96%. Pure Sr2Nb2O7 ceramics with larger grain size show a remarkable d33 of (1.7±0.1)pC/N while still with a very high Tc of (1340±4)∘C. The thermal depolarization temperature of samples with large grain sizes reach over 1200∘C and the thermal stability increased with increasing of grain size. The ferroelectric domains structure was observed by PFM and larger grain is easy to form ferroelectric domain then enhance piezoelectric properties. This study demonstrates enhanced piezoelectric properties can be achieved in pure Sr2Nb2O7 by solid state reaction method and bring great revitalization to the Sr2Nb2O7-based ceramics as a promising high-temperature piezoelectric material