Studies on the Thermolysis of Ether-Stabilized Lu(CH2SiMe3)3. Molecular Structure of Lu(CH2SiMe3)3(THF)(diglyme)

Lu(CH2SiMe3)3(THF)2 (2) decomposes slowly at room temperature with formation of Me4Si. In order to understand the mechanism of this elimination process, Lu(CH2SiMe3)3([D8]-THF)2 (1), Lu(CH2SiMe3)3(THF)(DME) (3), and Lu(CH2SiMe3)3(THF)(diglyme) (4) were prepared. The results of 1H NMR spectroscopic studies of the decomposition in solution exclude an α- as well as a β -H elimination mechanism and point towards a γ -H elimination. The molecular structure of 4 has been determined by single crystal X-ray diffraction.DFG, GRK 352, Synthetische, mechanistische und reaktionstechnische Aspekte von MetallkatalysatorenDFG, SPP 1166, Lanthanoidspezifische Funktionalitäten in Molekül und Materia

The BM@N Experiment at JINR: Status and Physics Program

BM@N (Baryonic Matter at Nuclotron) is the first experiment to be realized at the accelerator complex of NICA-Nuclotron at JINR (Dubna, Russia). The aim of the experiment is to study interactions of relativistic heavy ion beams with energy up to of strange mesons, multi-strange hyperons and light hyper-nuclei which are produced in nucleus-nucleus collisions close to the kinematic threshold. The BM@N set-up, the experimental program and first results of technical runs are presented

Charm production nearby threshold in pA-interactions at 70 GeV

The results of the SERP-E-184 experiment at the U-70 accelerator (IHEP, Protvino) are presented. Interactions of the 70 GeV proton beam with C, Si and Pb targets were studied to detect decays of charmed $D^0$, $\overline D^0$, $D^+$, $D^-$ mesons and $\Lambda _c^+$ baryon near their production threshold. Measurements of lifetimes and masses are shown a good agreement with PDG data. The inclusive cross sections of charm production and their A-dependencies were obtained. The yields of these particles are compared with the theoretical predictions and the data of other experiments. The measured cross section of the total open charm production ($\sigma _{\mathrm {tot}}(c\overline c)$ = 7.1 $\pm$ 2.3(stat) $\pm$1.4(syst) $\mu$b/nucleon) at the collision c.m. energy $\sqrt {s}$ = 11.8 GeV is well above the QCD model predictions. The contributions of different species of charmed particles to the total cross section of the open charm production in proton-nucleus interactions vary with energy.Comment: 4 pages, 6 pages, 38th International Conference on High Energy Physics 3-10 August 2016, Chicago, US

Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer

A new chemical series of antiproliferative compounds was identified via high-throughput screening on DU-145 human prostate carcinoma cell line (hit compound potency - 5.7 μM). Exploration of the two peripheral diversity vectors of the hit molecule in a hit-targeted library and testing of the resulting compounds led to SAR generalizations and identification of the 'best' pharmacophoric moieties. The latter were merged in a single compound that exhibited a 200-fold better potency than the original hit compound. Specific cancer cell cytotoxicity was confirmed for the most potent compounds

Triple GEM Tracking Detectors for the BM@N Experiment

BM@N (Baryonic Matter at the Nuclotron) is the fixed target experiment aimed to study nuclear matter in the relativistic heavy ion collisions at the Nuclotron accelerator in JINR. The BM@N tracking system is based on Gas Electron Multipliers (GEM) detectors, mounted inside the BM@N analyzing magnet. The structure of the GEM detectors and the results of study of their characteristics are presented. The GEM detectors are integrated into the BM@N experimental setup and data acquisition system. The results of the first test of the GEM tracking system in the technical run with the deuteron beam are shortly reviewed

Observation of narrow baryon resonance decaying into pKs0pK^0_s in pA-interactions at 70GeV/c70 GeV/c with SVD-2 setup

SVD-2 experiment data have been analyzed to search for an exotic baryon state, the $\Theta^+$-baryon, in a $pK^0_s$ decay mode at $70 GeV/c$ on IHEP accelerator. The reaction $pA \to pK^0_s+X$ with a limited multiplicity was used in the analysis. The $pK^0_s$ invariant mass spectrum shows a resonant structure with $M=1526\pm3(stat.)\pm 3(syst.) MeV/c^2$ and $\Gamma < 24 MeV/c^2$. The statistical significance of this peak was estimated to be of $5.6 \sigma$. The mass and width of the resonance is compatible with the recently reported $\Theta^+$- baryon with positive strangeness which was predicted as an exotic pentaquark ($uudd\bar{s}$) baryon state. The total cross section for $\Theta^+$ production in pN-interactions for $X_F\ge 0$ was estimated to be $(30\div120) \mu b$ and no essential deviation from A-dependence for inelastic events $(\sim A^{0.7})$ was found.Comment: 8 pages, 7 figures, To be submitted to Yadernaya Fizika. v3-v5 - Some references added, minor typos correcte