The role of recirculation in improving internal mixing and stabilityof flames

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76526/1/AIAA-1987-306-120.pd

LDV/Rayleigh scattering measurements to study the blowoff of swirling flames

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76566/1/AIAA-1986-593-553.pd

GPS Seismology for a moderate magnitude earthquake: Lessons learned from the analysis of the 31 October 2013 ML6.4 Ruisui (Taiwan) earthquake

The 31 October 2013 ML 6.4 Ruisui earthquake was well recorded by twelve 50-Hz, four 20-Hz and thirteen 1-Hz GPS receivers, and twenty-five strong motion stations located within the epicentral distance of 90 km in eastern Taiwan. Kinematic positioning solutions estimated by four GNSS software (TRACK, RTKLIB, GIPSY, VADASE) are used to derive the seismic waveforms and the co-seismic displacements for this event; strong motion accelerometers are used to verify the capability of high rate GPS to detect seismic waves generated by this earthquake. Results show that the coordinate repeatability of the GPS displacements time series are ~6 mm and ~20 mm standard deviation in the horizontal and vertical components respectively, after applying spatial filtering. The largest co-seismic displacement derived from high-rate GPS is nearly 15 centimeter at 5 km northeast of the epicenter. S waves and surface waves are successfully detected by motions of high-rate GPS and double-integrated accelerometers within the 15 km epicentral distance. For the first time twelve 50-Hz and four 20 Hz GPS observations for seismological study were used and analyzed in Taiwan; a clear benefit was evidenced with regard to the seismic waves features detection, with respect to the 1-Hz GPS data, so that ultra-high rate (> 1-Hz) observations can compensate the sparse coverage of seismic data, provided proper monuments for the GPS permanent stations are realized. Spectra analysis between co-located GPS and strong motion data further suggests that the optimal sampling rate for high-rate GPS Seismology study is 5 Hz. The 2013 Ruisui Taiwan earthquake recorded by the high-rate GPS permanent stations network in Taiwan demonstrates the benefits of GPS Seismology for a moderate size earthquake at a local scale

Self-Care and Well-Being Model for Elderly Women: A Comparison of Rural and Urban Areas

The purposes of this study were to examine the relationships among age, social class, perceived health, self-care, and well-being in urban and rural elderly women and to validate and compare two models using these two groups. A causal model of self-care and well-being was proposed for this study based on Orem's self-care model and empirical data. Data were collected using a survey-interview method. Of the 351 elderly women recruited, 159 were in the urban group and 192 in the rural group. Two models of self-care and well-being were tested using path analysis with the LISREL 8 program. The resultant models yielded a Chi-squared of 1.98 with two degrees of freedom (p = 0.37) in the urban group and a Chi-squared of 4.20 with three degrees of freedom (p = 0.24) in the rural group, indicating good fit between the data and the two models. These two models provide guidelines for community nurses to design appropriate self-care programs for elderly women

Visualization of the structure of premixed turbulent flames

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76854/1/AIAA-1988-146.pd

High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma.

Cancer may arise from dedifferentiation of mature cells or maturation-arrested stem cells. Previously we reported that definitive endoderm from which liver was derived, expressed Globo H, SSEA-3 and SSEA-4. In this study, we examined the expression of their biosynthetic enzymes, FUT1, FUT2, B3GALT5 and ST3GAL2, in 135 hepatocellular carcinoma (HCC) tissues by qRT-PCR. High expression of either FUT1 or B3GALT5 was significantly associated with advanced stages and poor outcome. Kaplan Meier survival analysis showed significantly shorter relapse-free survival (RFS) for those with high expression of either FUT1 or B3GALT5 (P = 0.024 and 0.001, respectively) and shorter overall survival (OS) for those with high expression of B3GALT5 (P = 0.017). Combination of FUT1 and B3GALT5 revealed that high expression of both genes had poorer RFS and OS than the others (P < 0.001). Moreover, multivariable Cox regression analysis identified the combination of B3GALT5 and FUT1 as an independent predictor for RFS (HR: 2.370, 95% CI: 1.505-3.731, P < 0.001) and OS (HR: 2.153, 95% CI: 1.188-3.902, P = 0.012) in HCC. In addition, the presence of Globo H, SSEA-3 and SSEA-4 in some HCC tissues and their absence in normal liver was established by immunohistochemistry staining and mass spectrometric analysis

Factors Affecting Aluminum Dissolve from Acidified Water Purification Sludge

Recovering resources from water purification sludge (WPS) have been gradually stipulated in environmental protection laws and regulations in many nations. Hence, reusing the WPS is becoming an important topic, and recovering alum from WPS is one of the many practical alternatives. Most previous research efforts have been conducted on studying the amphoteric characteristic of aluminum hydroxide for investigating the optimum pH range to dissolve the Al(III) species from WPS, but it has been lack of reaction kinetics or mechanisms related discussion. Therefore, in this investigation, water purification sludge (WPS) solution was broken by ultrasound to make particle size of reactants smaller, specific surface area larger. According to the reaction kinetics, these phenomena let the dissolved aluminum salt quantity increased and the reaction rate go faster

Nitric oxide levels of turbulent jet diffusion flames: Effects of residence time and damkohler number

The global residence time and the deviations from chemical equilibrium (i.e., the Damkohler number) were varied for a number of jet diffusion flames. The resulting effects on the nitric oxide emission index were measured and were compared with existing analysis. The global residence time is defined as Lf/UF, where Lf is the flame length and UF is the fuel jet velocity. Flame length is varied by increasing the jet diameter, by adding either premixed air or inerts to the fuel jet, or by adding a coaxial air stream. In particular, a unique jet flame was studied that is composed of helium---diluted hydrogen fuel; this flame is free of the complicating effects of flame radiation, buoyancy, and prompt NO and provides a useful baseline comparison to theory. It is found that NOx levels for three types of fuels were consistently less than levels predicted by thermal theory, which suggests that one or both of the two mechanisms that suppress NOx, namely strain and radiative cooling, are important. The use of a Damkohler number was found to successfully correlate the NOx data for the hydrogen/helium-air flames that have simple chemistry. As the helium concentration is increased in order to reduce the Damkohler number, the measured NOx emission index exceeds that of the equilibrium theory by as much as a factor of 24, which is further indication that it is important to add the correct nonequilibrium oxygen atom chemistry to current models.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30267/1/0000668.pd

FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding.

BackgroundThe transcription factor Nrf2 is a master regulator of antioxidant response. While Nrf2 activation may counter increasing oxidative stress in aging, its activation in cancer can promote cancer progression and metastasis, and confer resistance to chemotherapy and radiotherapy. Thus, Nrf2 has been considered as a key pharmacological target. Unfortunately, there are no specific Nrf2 inhibitors for therapeutic application. Moreover, high Nrf2 activity in many tumors without Keap1 or Nrf2 mutations suggests that alternative mechanisms of Nrf2 regulation exist.MethodsInteraction of FAM129B with Keap1 is demonstrated by immunofluorescence, colocalization, co-immunoprecipitation and mammalian two-hybrid assay. Antioxidative function of FAM129B is analyzed by measuring ROS levels with DCF/flow cytometry, Nrf2 activation using luciferase reporter assay and determination of downstream gene expression by qPCR and wester blotting. Impact of FAM129B on in vivo chemosensitivity is examined in mice bearing breast and colon cancer xenografts. The clinical relevance of FAM129B is assessed by qPCR in breast cancer samples and data mining of publicly available databases.FindingsWe have demonstrated that FAM129B in cancer promotes Nrf2 activity by reducing its ubiquitination through competition with Nrf2 for Keap1 binding via its DLG and ETGE motifs. In addition, FAM129B reduces chemosensitivity by augmenting Nrf2 antioxidative signaling and confers poor prognosis in breast and lung cancer.InterpretationThese findings demonstrate the important role of FAM129B in Nrf2 activation and antioxidative response, and identify FMA129B as a potential therapeutic target. FUND: The Chang Gung Medical Foundation (Taiwan) and the Ministry of Science and Technology (Taiwan)