Chiral fermions and anomaly cancellation on orbifolds with Wilson lines and flux

We consider six-dimensional supergravity compactified on orbifolds with Wilson lines and bulk flux. Torus Wilson lines are decomposed into Wilson lines around the orbifold fixed points, and twisted boundary conditions of matter fields are related to fractional localized flux. Both, orbifold singularities and flux lead to chiral fermions in four dimensions. We show that in addition to the standard bulk and fixed point anomalies the Green-Schwarz term also cancels the four-dimensional anomaly induced by the flux background. The two axions contained in the antisymmetric tensor field both contribute to the cancellation of the four-dimensional anomaly and the generation of a vector boson mass via the Stueckelberg mechanism. An orthogonal linear combination of the axions remains massless and couples to the gauge field in the standard way. Furthermore, we construct convenient expressions for the wave functions of the zero modes and relate their multiplicity and behavior at the fixed points to the bulk flux quanta and the Wilson lines.Comment: 30 pages, 4 figures, 1 table, clarifying remarks adde

Moduli backreaction and supersymmetry breaking in string-inspired inflation models

We emphasize the importance of effects from heavy fields on supergravity models of inflation. We study, in particular, the backreaction of stabilizer fields and geometric moduli in the presence of supersymmetry breaking. Many effects do not decouple even if those fields are much heavier than the inflaton field. We apply our results to successful models of Starobinsky-like inflation and natural inflation. In most scenarios producing a plateau potential it proves difficult to retain the flatness of the potential after backreactions are taken into account. Some of them are incompatible with non-perturbative moduli stabilization. In natural inflation there exist a number of models which are not constrained by backreactions at all. In those cases the correction terms from heavy fields have the same inflaton-dependence as the uncorrected potential, so that inflation may be possible even for very large gravitino masses.Comment: 29 pages, 1 figure, comments added, subsection 2.3 added, published versio

Rational F-Theory GUTs without exotics

We construct F-theory GUT models without exotic matter, leading to the MSSM matter spectrum with potential singlet extensions. The interplay of engineering explicit geometric setups, absence of four-dimensional anomalies, and realistic phenomenology of the couplings places severe constraints on the allowed local models in a given geometry. In constructions based on the spectral cover we find no model satisfying all these requirements. We then provide a survey of models with additional U(1) symmetries arising from rational sections of the elliptic fibration in toric constructions and obtain phenomenologically appealing models based on SU(5) tops. Furthermore we perform a bottom-up exploration beyond the toric section constructions discussed in the literature so far and identify benchmark models passing all our criteria, which can serve as a guideline for future geometric engineering.Comment: 27 Pages, 1 Figur

A perfect match of MSSM-like orbifold and resolution models via anomalies

Compactification of the heterotic string on toroidal orbifolds is a promising set-up for the construction of realistic unified models of particle physics. The target space dynamics of such models, however, drives them slightly away from the orbifold point in moduli space. This resolves curvature singularities, but makes the string computations very difficult. On these smooth manifolds we have to rely on an effective supergravity approximation in the large volume limit. By comparing an orbifold example with its blow-up version, we try to transfer the computational power of the orbifold to the smooth manifold. Using local properties, we establish a perfect map of the the chiral spectra as well as the (local) anomalies of these models. A key element in this discussion is the Green-Schwarz anomaly polynomial. It allows us to identify those redefinitions of chiral fields and localized axions in the blow-up process which are relevant for the interactions (such as Yukawa-couplings) in the model on the smooth space.Comment: 2+35 pages, 1 figur

The endocannabinoid system controls food intake via olfactory processes

Comment in Sensory systems: the hungry sense. [Nat Rev Neurosci. 2014] Inhaling: endocannabinoids and food intake. [Nat Neurosci. 2014]; International audience; Hunger arouses sensory perception, eventually leading to an increase in food intake, but the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB1) receptors promote food intake in fasted mice by increasing odor detection. CB1 receptors were abundantly expressed on axon terminals of centrifugal cortical glutamatergic neurons that project to inhibitory granule cells of the main olfactory bulb (MOB). Local pharmacological and genetic manipulations revealed that endocannabinoids and exogenous cannabinoids increased odor detection and food intake in fasted mice by decreasing excitatory drive from olfactory cortex areas to the MOB. Consistently, cannabinoid agonists dampened in vivo optogenetically stimulated excitatory transmission in the same circuit. Our data indicate that cortical feedback projections to the MOB crucially regulate food intake via CB1 receptor signaling, linking the feeling of hunger to stronger odor processing. Thus, CB1 receptor-dependent control of cortical feedback projections in olfactory circuits couples internal states to perception and behavior

Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo

Tumor cells exhibit an altered metabolism characterized by elevated aerobic glycolysis and lactate secretion which is supported by an increase in glucose transport and consumption. We hypothesized that reducing or eliminating the expression of the most prominently expressed glucose transporter(s) would decrease the amount of glucose available to breast cancer cells thereby decreasing their metabolic capacity and proliferative potential

Gauged Linear Sigma Models for toroidal orbifold resolutions

Toroidal orbifolds and their resolutions are described within the framework of (2,2) Gauged Linear Sigma Models (GLSMs). Our procedure describes two-tori as hypersurfaces in (weighted) projective spaces. The description is chosen such that the orbifold singularities correspond to the zeros of their homogeneous coordinates. The individual orbifold singularities are resolved using a GLSM guise of non-compact toric resolutions, i.e. replacing discrete orbifold actions by Abelian worldsheet gaugings. Given that we employ the same global coordinates for both the toroidal orbifold and its resolutions, our GLSM formalism confirms the gluing procedure on the level of divisors discussed by Lust et al. Using our global GLSM description we can study the moduli space of such toroidal orbifolds as a whole. In particular, changes in topology can be described as phase transitions of the underlying GLSM. Finally, we argue that certain partially resolvable GLSMs, in which a certain number of fixed points can never be resolved, might be useful for the study of mini-landscape orbifold MSSMs.Comment: 71 pages, 2 figure

Searching for the Standard Model in the String Landscape : SUSY GUTs

The goal of the present review article is to describe the ingredients necessary to find the Standard Model in the string landscape.Comment: 70 pages, 20 figures, this review article will be published in Reports on Progress in Physic