3,916 research outputs found
Viruses: Friends and Foes
In this chapter, we will review how viruses can be used to positively affect joints and cartilage of their hosts. Many viruses are arthrogenic, and cause persistent and debilitating arthritis. Even those viruses that are not typically arthrogenic can also cause bone lesions as secondary pathogenesis. Some of these foes include members of the alphaviruses, like chikungunya and Ross River viruses, the rubiviruses, such as rubella, and erythoparvoviruses, like parvovirus B19. Some more uncommon viruses, which can occasionally have detrimental effects on their hosts’ joints, include herpes simplex virus, varicella zoster, mumps, human cytomegalovirus, avian orthoreovirus, and caprine arthritis-encephalitis virus. Despite some viruses having negative impacts on cartilage and joints, others have been used as an effective means of gene therapy for bone and cartilage repair. We will take an in-depth look at the current therapeutic strategies for treating arthritis using various viral vectors
Self Calibration of Tomographic Weak Lensing for the Physics of Baryons to Constrain Dark Energy
Numerical studies indicate that uncertainties in the treatment of baryonic
physics can affect predictions for shear power spectra at a level that is
significant for forthcoming surveys such as DES, SNAP, and LSST.
Correspondingly, we show that baryonic effects can significantly bias dark
energy parameter measurements. Eliminating such biases by neglecting
information in multipoles beyond several hundred leads to weaker parameter
constraints by a factor of approximately 2 to 3 compared with using information
out to multipoles of several thousand. Fortunately, the same numerical studies
that explore the influence of baryons indicate that they primarily affect power
spectra by altering halo structure through the relation between halo mass and
mean effective halo concentration. We explore the ability of future weak
lensing surveys to constrain both the internal structures of halos and the
properties of the dark energy simultaneously as a first step toward self
calibrating for the physics of baryons. This greatly reduces parameter biases
and no parameter constraint is degraded by more than 40% in the case of LSST or
30% in the cases of SNAP or DES. Modest prior knowledge of the halo
concentration relation greatly improves even these forecasts. Additionally, we
find that these surveys can constrain effective halo concentrations near
m~10^14 Msun/h and z~0.2 to better than 10% with shear power spectra alone.
These results suggest that inferring dark energy parameters with measurements
of shear power spectra can be made robust to baryonic effects and may
simultaneously be competitive with other methods to inform models of galaxy
formation. (Abridged)Comment: 18 pages, 11 figures. Minor changes reflecting referee's comments.
Results and conclusions unchanged. Accepted for publication in Physical
Review
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The small open-economy New Keynesian Phillips Curve: empirical evidence and implied inflation dynamics
In this paper we apply GMM estimation to assess the relevance of domestic versus external determinants of CPI inflation dynamics in a sample of OECD countries typically classified as open economies. The analysis is based on a variant of the small open-economy New Keynesian Phillips Curve derived in Galà and Monacelli (Rev Econ Stud 72:707–734, 2005), where the novel feature is that expectations about fluctuations in the terms of trade enter explicitly. For most countries in our sample the expected relative change in the terms of trade emerges as the more relevant inflation driver than the contemporaneous domestic output gap
Radially restricted linear energy transfer for high-energy protons: A new analytical approach
Radially restricted linear energy transfer (LET) is a basic physical parameter relevant to radiation biology and radiation protection. In this report a convenient method is presented for the analytical computation of this quantity without the need for complicated simulation. The method uses the energy-re-stricted LETL, as recently redefined in a 1993 ICRU draft document and supplements it by a relatively simple term that represents the energy of fast rays lost within distancer from the track core. The method provides a better fit than other models and is valid over the entire range of radial distance from track center to the maximum radial distance traveled by the most energetic secondary electrons.L r computed by this approach differs only a few percent from the values
Contribution to the international symposium on heavy ions research: space, radiation protection and therapy, 21–24 March 1994, Sophia-Antipolis, Franc
Matching Conditions in Atomistic-Continuum Modeling of Materials
A new class of matching condition between the atomistic and continuum regions
is presented for the multi-scale modeling of crystals. They ensure the accurate
passage of large scale information between the atomistic and continuum regions
and at the same time minimize the reflection of phonons at the interface. These
matching conditions can be made adaptive if we choose appropriate weight
functions. Applications to dislocation dynamics and friction between
two-dimensional atomically flat crystal surfaces are described.Comment: 6 pages, 4 figure
Battered Women\u27s Compliance-Gaining Strategies as a Function of Argumentativeness and Verbal Aggression
This study investigated (1) the type of compliance-gaining strategies that battered women reported using in domestic conflicts and (2) whether these strategies related to the battered women\u27s verbal aggression and argumentativeness. Participants in this study were 115 abused women who were seeking refuge from abusive spouses in temporary shelters for battered women. The results suggest that battered women most frequently reported using indirect strategies. Aversive Stimulation (i.e., pouting sulking, crying) and ingratiation (i.e., manipulation in the form of affection or favor-doing) were the top two strategies reported. Furthermore, a canonical correlation analysis resulted in an overall significant relationship between compliance-gaining strategies and argumentativeness and verbal aggressiveness
A Twins Study of Communicative Adaptability: Heritability of Individual Differences
Recently, a model of communication theory and research has appeared in the literature within which stable individual differences in communication behavior represent individual differences in activation thresholds of neurobiological systems. The neurobiological systems thought to underly communication traits and behavior are assumed to be primarily due to genetic inheritance. As such, the model assigns a limited role to adaptability in social situations, instead positing communication adaptability as an inherited trait. In the present study, heritability estimates for the dimensions of communicative adaptability were derived from correlations based on identical and fraternal twins\u27 responses to a multidimensional communicative adaptability measure. Results indicated that social composure was 88% heritable, wit was 90% heritable, social confirmation was 37% heritable, articulation ability, and appropriate disclosure were 0% heritable. Theoretical implications are discussed
Drag Reduction by Polymers in Wall Bounded Turbulence
We address the mechanism of drag reduction by polymers in turbulent wall
bounded flows. On the basis of the equations of fluid mechanics we present a
quantitative derivation of the "maximum drag reduction (MDR) asymptote" which
is the maximum drag reduction attained by polymers. Based on Newtonian
information only we prove the existence of drag reduction, and with one
experimental parameter we reach a quantitative agreement with the experimental
measurements.Comment: 4 pages, 1 fig., included, PRL, submitte
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