High-pressure promoted combustion chamber

In the preferred embodiment of the promoted combusiton chamber disclosed herein, a thick-walled tubular body that is capable of withstanding extreme pressures is arranged with removable upper and lower end closures to provide access to the chamber for dependently supporting a test sample of a material being evaluated in the chamber. To facilitate the real-time analysis of a test sample, several pressure-tight viewing ports capable of withstanding the simulated environmental conditions are arranged in the walls of the tubular body for observing the test sample during the course of the test. A replaceable heat-resistant tubular member and replaceable flame-resistant internal liners are arranged to be fitted inside of the chamber for protecting the interior wall surfaces of the combustion chamber during the evaluation tests. Inlet and outlet ports are provided for admitting high-pressure gases into the chamber as needed for performing dynamic analyses of the test sample during the course of an evaluation test

Elastin metabolism and chemistry: potential roles in lung development and structure.

Elastic fibers are important for elasticity and extensibility of lung tissue. In the developing lung, elastic fibers appear in greatest numbers during the process or period of alveolarization . A variety of mesenchymal cells in lung appear responsible for elastin synthesis. Elastin is a novel protein both from the standpoint of its processing into elastic fibers and chemical properties. For example, elastin undergoes posttranslational modification before its assembly into fibers. These steps include limited proteolysis, hydroxylation of prolyl residues and the oxidative deamination of lysyl residues prior to their incorporation into the crosslinks that covalently bond together polypeptide chains of elastin. The crosslinking amino acids include lysinonorleucine , merodesmosine and desmosine isomers. A key enzyme that controls this process is lysyl oxidase. Lysyl oxidase is a copper metalloprotein whose activity is responsive to and modulated by environmental insults, nutrition deficiencies and the administration of various pharmacological agents. Regarding chemical properties, elastin is one of the most apolar proteins secreted by mammalian cells. Moreover, elastin is one of the most long-lived proteins secreted into the extracellular matrix. In relationship to its processing into elastic fibers and chemical properties, details related to major aspects of elastin metabolism as well as speculation on its potential as a factor in lung development and disease are discussed

A zinc transporter gene required for development of the nervous system.

The essentiality of zinc for normal brain development is well established. It has been suggested that primary and secondary zinc deficiencies can contribute to the occurrence of numerous human birth defects, including many involving the central nervous system. In a recent study, we searched for zinc transporter genes that were critical for neurodevelopment. We confirmed that ZIP12 is a zinc transporter encoded by the gene slc39a12 that is highly expressed in the central nervous systems of human, mouse, and frog (Xenopus tropicalis).Using loss-of-function methods, we determined that ZIP12 is required for neuronal differentiation and neurite outgrowth and necessary for neurulation and embryonic viability. These results highlight an essential need for zinc regulation during embryogenesis and nervous system development. We suggest that slc39a12 is a candidate gene for inherited neurodevelopmental defects in humans

Uniaxial pressure dependence of magnetic order in MnSi

We report comprehensive small angle neutron scattering (SANS) measurements complemented by ac susceptibility data of the helical order, conical phase and skyrmion lattice phase (SLP) in MnSi under uniaxial pressures. For all crystallographic orientations uniaxial pressure favours the phase for which a spatial modulation of the magnetization is closest to the pressure axis. Uniaxial pressures as low as 1kbar applied perpendicular to the magnetic field axis enhance the skyrmion lattice phase substantially, whereas the skyrmion lattice phase is suppressed for pressure parallel to the field. Taken together we present quantitative microscopic information how strain couples to magnetic order in the chiral magnet MnSi.Comment: 23 pages, includes supplemen

Radio seismology of the outer solar corona

Observed oscillations of coronal loops in EUV lines have been successfully used to estimate plasma parameters in the inner corona (< 0.2 R_0, where R_0 is the solar radius). However, coronal seismology in EUV lines fails for higher altitudes because of rapid decrease in line intensity. We aim to use radio observations to estimate the plasma parameters of the outer solar corona (> 0.2 R_0). We use the large Ukrainian radio telescope URAN-2 to observe type IV radio burst at the frequency range of 8-32 MHz during the time interval of 09:50-12:30 UT in April 14, 2011. The burst was connected to C2.3 flare, which occurred in AR 11190 during 09:38-09:49 UT. The dynamic spectrum of radio emission shows clear quasi-periodic variations in the emission intensity at almost all frequencies. Wavelet analysis at four different frequencies (29 MHz, 25 MHz, 22 MHz and 14 MHz) shows the quasi-periodic variation of emission intensity with periods of 34 min and 23 min. The periodic variations can be explained by the first and second harmonics of vertical kink oscillation of transequatorial coronal loops, which were excited by the same flare. The apex of transequatorial loops may reach up to 1.2 R_0 altitude. We derive and solve the dispersion relation of trapped MHD oscillations in a longitudinally inhomogeneous magnetic slab. The analysis shows that a thin (with width to length ratio of 0.1), dense (with the ratio of internal and external densities of > 20) magnetic slab with weak longitudinal inhomogeneity may trap the observed oscillations. Seismologically estimated Alfv\'en speed inside the loop at the height of 1 R_0 is 1000 km/s. Then the magnetic field strength at this height is estimated as 0.9 G. Extrapolation of magnetic field strength to the inner corona gives 10 G at the height of 0.1 R_0.Comment: 12 pages, 10 figures, Accepted in A&