Mineralogy of Tongue of the ocean sediments

The carbonate mineralogy of 25 short cores from the Tongue of the Ocean has been determined. Evidence presented in this paper indicates that carbonate mineralogy may reflect Pleistocene sea-level changes due to an increased contribution of low magnesium calcite from the subaerially exposed Bahama Banks when sea levels were low. It is suggested that this relationship of mineralogy to sea level may find wide application in the study of carbonate sedimentation in intermediate-depth water, proximal to carbonate banks

Large Payload Transportation and Test Considerations

Ironically, the limiting factor to a national heavy lift strategy may not be the rocket technology needed to throw a heavy payload, but rather the terrestrial infrastructure - roads, bridges, airframes, and buildings - necessary to transport, acceptance test, and process large spacecraft. Failure to carefully consider how large spacecraft are designed, and where they are manufactured, tested, or launched, could result in unforeseen cost to modify/develop infrastructure, or incur additional risk due to increased handling or elimination of key verifications. During test and verification planning for the Altair project, a number of transportation and test issues related to the large payload diameter were identified. Although the entire Constellation Program - including Altair - was canceled in the 2011 NASA budget, issues identified by the Altair project serve as important lessons learned for future payloads that may be developed to support national "heavy lift" strategies. A feasibility study performed by the Constellation Ground Operations (CxGO) project found that neither the Altair Ascent nor Descent Stage would fit inside available transportation aircraft. Ground transportation of a payload this large over extended distances is generally not permitted by most states, so overland transportation alone would not have been an option. Limited ground transportation to the nearest waterway may be permitted, but water transportation could take as long as 66 days per production unit, depending on point of origin and acceptance test facility; transportation from the western United States would require transit through the Panama Canal to access the Kennedy Space Center launch site. Large payloads also pose acceptance test and ground processing challenges. Although propulsion, mechanical vibration, and reverberant acoustic test facilities at NASA s Plum Brook Station have been designed to accommodate large spacecraft, special handling and test work-arounds may be necessary, which could increase cost, schedule, and technical risk. Once at the launch site, there are no facilities currently capable of accommodating the combination of large payload size and hazardous processing (which includes hypergolic fuels, pyrotechnic devices, and high pressure gasses)

UK medical students’ self-reported knowledge and harm assessment of psychedelics and their application in clinical research: a cross-sectional study

Objective To capture UK medical students’ self-reported knowledge and harm assessment of psychedelics and to explore the factors associated with support for changing the legal status of psychedelics to facilitate further clinical research. Design Cross-sectional, anonymous online survey of UK medical students using a non-random sampling method. Setting UK medical schools recognised by the General Medical Council. Participants 132 medical students who had spent an average of 3.8 years (SD=1.4; range: 1–6) in medical school. Results Most students (83%) reported that they were aware of psychedelic research and only four participants (3%) said that they were not interested in learning more about this type of research. Although medical students’ harm assessment of psychedelics closely aligned with that of experts, only 17% of students felt well-educated on psychedelic research. Teachings on psychedelics were only rarely encountered in their curriculum (psilocybin: 14.1 (SD=19.9), scale: 0 (never) to 100 (very often)). Time spent at medical schools was not associated with more knowledge about psychedelics (r=0.12, p=0.129). On average, this sample of medical students showed strong support for changing the legal status of psychedelics to facilitate further research into their potential clinical applications (psilocybin: 80.2 (SD=24.8), scale: 0 (strongly oppose) to 100 (strongly support)). Regression modelling indicated that greater knowledge of psychedelics (p<0.001), lower estimated harm scores (p<0.001), more time spent in medical school (p=0.024) and lower perceived effectiveness of non-pharmacological mental health treatments (p=0.044) were associated with greater support for legal status change. Conclusions Our findings reveal a significant interest among UK medical students to learn more about psychedelic research and a strong support for further psychedelic research. Future studies are needed to examine how medical education could be refined to adequately prepare medical students for a changing healthcare landscape in which psychedelic-assisted therapy could soon be implemented in clinical practice

Psychedelics, Mystical Experience, and Therapeutic Efficacy: A Systematic Review

The mystical experience is a potential psychological mechanism to influence outcome in psychedelic therapy. It includes features such as oceanic boundlessness, ego dissolution, and universal interconnectedness, which have been closely linked to both symptom reduction and improved quality of life. In this review, 12 studies of psychedelic therapy utilizing psilocybin, ayahuasca, or ketamine were analyzed for association between mystical experience and symptom reduction, in areas as diverse as cancer-related distress, substance use disorder, and depressive disorders to include treatment-resistant. Ten of the twelve established a significant association of correlation, mediation, and/or prediction. A majority of the studies are limited, however, by their small sample size and lack of diversity (gender, ethnic, racial, educational, and socioeconomic), common in this newly re-emerging field. Further, 6 out of 12 studies were open-label in design and therefore susceptible to bias. Future studies of this nature should consider a larger sample size with greater diversity and thus representation by use of randomized design. More in-depth exploration into the nature of mystical experience is needed, including predictors of intensity, in order to maximize its positive effects on treatment outcome benefits and minimize concomitant anxiety.Systematic Review Registration: PROSPERO, identifier CRD42021261752

Magnetohydrodynamic waves in solar partially ionized plasmas: two-fluid approach

We derive the dynamics of magnetohydrodynamic waves in two-fluid partially ionized plasmas and to compare the results with those obtained under single-fluid description. Two-fluid magnetohydrodynamic equations are used, where ion-electron plasma and neutral particles are considered as separate fluids. Dispersion relations of linear magnetohydrodynamic waves are derived for simplest case of homogeneous medium. Frequencies and damping rates of waves are obtained for different parameters of background plasma. We found that two- and single-fluid descriptions give similar results for low frequency waves. However, the dynamics of MHD waves in two-fluid approach is significantly changed when the wave frequency becomes comparable or higher than ion-neutral collision frequency. Alfven and fast magneto-acoustic waves attain their maximum damping rate at particular frequencies (for example, the peak frequency equals 2.5 ion-neutral collision frequency for 50 % of neutral Hydrogen) in wave spectrum. The damping rates are reduced for higher frequency waves. The new mode of slow magneto-acoustic wave appears for higher frequency branch, which is connected to neutral hydrogen fluid. The single-fluid approach perfectly deals with slow processes in partially ionized plasmas, but fails for time-scales smaller than ion-neutral collision time. Therefore, two-fluid approximation should be used for the description of relatively fast processes. Some results of single-fluid description, for example the damping of high-frequency Alfven waves in the solar chromosphere due to ion-neutral collisions, should be revised in future.Comment: 8 pages, 7 figures, accepted in A&

A Quantitative Simulation-based Modeling Approach for College Counseling Centers

College counseling centers in various universities have been tasked with the important responsibility of attending to the mental health needs of their students. Owing to the unprecedented recent surge of demand for such services, college counseling centers are facing several crippling resource-level challenges. This is leading to longer wait times which limits access to critical mental health services. To address these challenges, we construct a discrete-event simulation model that captures several intricate details of their operations and provides a data-driven framework to quantify the effect of different policy changes. In contrast to existing work on this matter, which are primarily based on qualitative assessments, the considered quantitative approach has the potential to lead to key observations that can assist counseling directors in constructing a system with desirable performance. To demonstrate the benefit of the considered simulation model, we use data specific to Texas A&M's Counseling & Psychological Services to run a series of numerical experiments. Our results demonstrate the predictive power of the simulation model, highlight a number of key observations, and identify policy changes that result in desirable system performance

The development of psilocybin therapy for treatment-resistant depression: an update

Psilocybin is a classic psychedelic drug that has attracted increasing research interest over the past 10 years as a possible treatment for mood, anxiety and related conditions. Initial phase 2 clinical trials of psilocybin given alongside psychological support for major depression and treatment-resistant depression (TRD) demonstrated encouraging signs of basic safety, further confirmed by a large study in groups of healthy volunteers. The first international multi-centre randomised controlled trial was published in 2022, with signs of efficacy for the 25 mg dose condition in people with TRD when compared with an active placebo. Phase 3 trials in TRD are scheduled to start in 2023. Early evidence suggests that single doses of psilocybin given with psychological support induce rapid improvement in depressive symptoms that endure for some weeks. We therefore provide a timely update to psychiatrists on what psilocybin therapy is, what it is not, and the current state of the evidence-base