Responding to Discrimination as a Function of Meritocracy Beliefs and Personal Experiences: Testing the Model of Shattered Assumptions

We examined whether the model of shattered assumptions (Janoff-Bulman, 1992) could be applied to the reactions of victims of discrimination. Consistent with this model, it was hypothesized that those whose positive world assumptions are inconsistent with their negative experiences of discrimination would report more negative responses than those whose world assumptions match their experience. Disadvantaged group (both gender and ethnicity) members’ responses to discrimination (self-esteem, collective action, intergroup anxiety) were predicted from their meritocracy beliefs and personal experiences of discrimination. Regression analyses showed a significant interaction between meritocracy beliefs and personal discrimination such that among those who reported personal discrimination, stronger beliefs that the meritocracy exists predicted decreased self-esteem and collective action as well as increased intergroup anxiety. Among those who reported little personal discrimination, stronger beliefs that the meritocracy exists predicted increased self-esteem. Implications for promoting a critical view of the social system was discussed

Umgang mit chronischen Schmerzen bei Kindern und Jugendlichen mit psychischen Erkrankungen: Wissensstand und Fortbildungs- Besuch von Mitarbeitern in der Kinder- und Jugendpsychiatrie

Chronische Schmerzen sind bei Kindern und Jugendlichen mit psychischen Erkran- kungen insgesamt ein häufiges Phänomen. Grundlage einer fachgerechten multimo- dalen Schmerztherapie ist ein fundierter Wissensstand der Mitarbeiter der unter- schiedlichen Berufsgruppen. In dieser Untersuchung konnte gezeigt werden, dass besonders bei den Berufsgrup- pen, welche die meiste Zeit mit den Patienten verbringen, wie Krankenpflege- und Er- ziehungsdienst schmerztherapeutische Kenntnisse zu verbessern sind. Es konnte zu- dem gezeigt werden, dass Mitarbeiter, welche ihre Kenntnisse durch Fortbildungen erlangt haben, einen höheren Wissensstand besitzen. Folglich scheinen Fortbildungen ein geeignetes Mittel zu sein, um den Wissensstand zu verbessern. Diese Arbeit konnte zudem verhaltenstheoretisch beschrieben, welche individuellen Aspekte den Fortbildungsbesuch der Mitarbeiter beeinflussen. Diese individuellen Besonderheiten scheinen neben berufsgruppenspezifischen Aspekten auch die eigene Schmerzerfah- rung und die emotionale Verarbeitung des eigenen Schmerzerlebens zu sein. Nach dem Modell der Theorie des Geplanten Verhaltens scheint insbesondere die wahrge- nommene Verhaltenskontrolle ein wichtiger Modulator für den Fortbildungsbesuch zu sein. Somit könnte es eine Strategie sein, die Einbindung von Fortbildungen in den berufli- chen Alltag so zu verbessern, dass mehr Mitarbeiter Fortbildungen besuchen. Fortbil- dungen sollten also nicht mit der Bewältigung der tagesaktuellen Aufgaben kollidieren und im Rahmen der Arbeitszeit besuchbar sein. Unter Miteinbeziehung der sozialen Normen sollte der Arbeitgeber unter den Mitarbeitern die positive Bewertung des Fort- bildungsbesuches aktiv unterstützen. Konkrete Maßnahmen könnten eine Freistellung von der Arbeit für einen Fortbildungs- besuch und der Fortbildungsbesuch von Vorgesetzten mit Vorbildfunktion sein. Dies könnte durch Erweiterung des Wissensstandes der Mitarbeiter maßgeblich die Behandlung von Kindern und Jugendlichen mit chronischen Schmerzen und psychi- schen Erkrankungen verbessern

Responding to Discrimination as a Function of Meritocracy Beliefs and Personal Experiences: Testing the Model of Shattered Assumptions

We examined whether the model of shattered assumptions (Janoff-Bulman, 1992) could be applied to the reactions of victims of discrimination. Consistent with this model, it was hypothesized that those whose positive world assumptions are inconsistent with their negative experiences of discrimination would report more negative responses than those whose world assumptions match their experience. Disadvantaged group (both gender and ethnicity) members' responses to discrimination (self-esteem, collective action, intergroup anxiety) were predicted from their meritocracy beliefs and personal experiences of discrimination. Regression analyses showed a significant interaction between meritocracy beliefs and personal discrimination such that among those who reported personal discrimination, stronger beliefs that the meritocracy exists predicted decreased self-esteem and collective action as well as increased intergroup anxiety. Among those who reported little personal discrimination, stronger beliefs that the meritocracy exists predicted increased self-esteem. Implications for promoting a critical view of the social system is discussed

Influence of Measurement Depth and Acquisition Parameters on Shear Wave Speed and Shear Wave Dispersion in Certified Phantoms Using a Canon Aplio Clinical Ultrasound Scanner

OBJECTIVE The aim of the work described here was to investigate the relative contribution of confounding factors on liver shear wave speed (SWS) and shear wave dispersion slope (SWDS) measurements in three certified phantoms using a Canon Aplio clinical ultrasound scanner. METHODS A Canon Aplio i800 i-series ultrasound system (Canon Medical Systems Corporation, Otawara, Tochigi, Japan) with i8CX1 convex array (center frequency = 4 MHz) was used to examine dependencies caused by the depth, width and height of the acquisition box (AQB), the depth and size of the region of interest (ROI), the AQB angle and the pressure of the ultrasound probe on the surface of the phantom. RESULTS Results revealed that depth is the most significant confounder in both SWS and SWDS measurements. AQB angle, height and width and ROI size exhibited minimal confounding effects on measurements. For SWS, the most consistent measurement depth is when the top of the AQB is placed between 2 and 4 cm, and the ROI is located between 3 and 7 cm deep. For SWDS, results indicate that measurement values significantly decrease with depth from the surface of the phantom until approximately 7 cm deep, and consequently no stable area of AQB placement or ROI depth exists. CONCLUSION In contrast to SWS, the same ideal acquisition depth range cannot necessarily be applied to SWDS measurements because of a significant depth dependency

Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients.

OBJECTIVE:Epigenetic modifications have previously been associated with rheumatoid arthritis (RA). In this study, we aimed to determine whether differential DNA methylation in peripheral blood cell subpopulations is associated with any of 4 clinical outcomes among RA patients. METHODS:Peripheral blood samples were obtained from 63 patients in the University of California, San Francisco RA cohort (all satisfied the American College of Rheumatology classification criteria; 57 were seropositive for rheumatoid factor and/or anti-cyclic citrullinated protein). Fluorescence-activated cell sorting was used to separate the cells into 4 immune cell subpopulations (CD14+ monocytes, CD19+ B cells, CD4+ naive T cells, and CD4+ memory T cells) per individual, and 229 epigenome-wide DNA methylation profiles were generated using Illumina HumanMethylation450 BeadChips. Differentially methylated positions and regions associated with the Clinical Disease Activity Index score, erosive disease, RA Articular Damage score, Sharp score, medication at time of blood draw, smoking status, and disease duration were identified using robust regression models and empirical Bayes variance estimators. RESULTS:Differential methylation of CpG sites associated with clinical outcomes was observed in all 4 cell types. Hypomethylated regions in the CYP2E1 and DUSP22 gene promoters were associated with active and erosive disease, respectively. Pathway analyses suggested that the biologic mechanisms underlying each clinical outcome are cell type-specific. Evidence of independent effects on DNA methylation from smoking, medication use, and disease duration were also identified. CONCLUSION:Methylation signatures specific to RA clinical outcomes may have utility as biomarkers or predictors of exposure, disease progression, and disease severity

Fully automated breast segmentation on spiral breast computed tomography images

INTRODUCTION The quantification of the amount of the glandular tissue and breast density is important to assess breast cancer risk. Novel photon-counting breast computed tomography (CT) technology has the potential to quantify them. For accurate analysis, a dedicated method to segment the breast components-the adipose and glandular tissue, skin, pectoralis muscle, skinfold section, rib, and implant-is required. We propose a fully automated breast segmentation method for breast CT images. METHODS The framework consists of four parts: (1) investigate, (2) segment the components excluding adipose and glandular tissue, (3) assess the breast density, and (4) iteratively segment the glandular tissue according to the estimated density. For the method, adapted seeded watershed and region growing algorithm were dedicatedly developed for the breast CT images and optimized on 68 breast images. The segmentation performance was qualitatively (five-point Likert scale) and quantitatively (Dice similarity coefficient [DSC] and difference coefficient [DC]) demonstrated according to human reading by experienced radiologists. RESULTS The performance evaluation on each component and overall segmentation for 17 breast CT images resulted in DSCs ranging 0.90-0.97 and in DCs 0.01-0.08. The readers rated 4.5-4.8 (5 highest score) with an excellent inter-reader agreement. The breast density varied by 3.7%-7.1% when including mis-segmented muscle or skin. CONCLUSION The automatic segmentation results coincided with the human expert's reading. The accurate segmentation is important to avoid the significant bias in breast density analysis. Our method enables accurate quantification of the breast density and amount of the glandular tissue that is directly related to breast cancer risk

Influence of CT Image Matrix Size and Kernel Type on the Assessment of HRCT in Patients with SSC-ILD

BACKGROUND Interstitial lung disease (ILD) is a frequent complication of systemic sclerosis (SSc), and its early detection and treatment may prevent deterioration of lung function. Different vendors have recently made larger image matrices available as a post-processing option for computed tomography (CT), which could facilitate the diagnosis of SSc-ILD. Therefore, the objective of this study was to assess the effect of matrix size on lung image quality in patients with SSc by comparing a 1024-pixel matrix to a standard 512-pixel matrix and applying different reconstruction kernels. METHODS Lung scans of 50 patients (mean age 54 years, range 23-85 years) with SSc were reconstructed with these two different matrix sizes, after determining the most appropriate kernel in a first step. Four observers scored the images on a five-point Likert scale regarding image quality and detectability of clinically relevant findings. RESULTS Among the eight tested kernels, the Br59-kernel (sharp) reached the highest score (19.48 ± 3.99), although differences did not reach statistical significance. The 1024-pixel matrix scored higher than the 512-pixel matrix HRCT overall (p = 0.01) and in the subcategories sharpness (p < 0.01), depiction of bronchiole (p < 0.01) and overall image impression (p < 0.01), and lower for the detection of ground-glass opacities (GGO) (p = 0.04). No significant differences were found for detection of extent of reticulations/bronchiectasis/fibrosis (p = 0.50) and image noise (p = 0.09). CONCLUSIONS Our results show that with the use of a sharp kernel, the 1024-pixel matrix HRCT, provides a slightly better subjective image quality in terms of assessing interstitial lung changes, whereby GGO are more visible on the 512-pixel matrix. However, it remains to be answered to what extent this is related to the improved representation of the smallest structures

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes.

ObjectiveTo determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples.MethodsFor this study, 371 genome-wide DNA methylation profiles were measured using Illumina HumanMethylation450 BeadChips in PB samples from 63 patients with RA and 31 unaffected control subjects, specifically in the cell subsets of CD14+ monocytes, CD19+ B cells, CD4+ memory T cells, and CD4+ naive T cells.ResultsOf 5,532 hypermethylated FLS candidate CpGs, 1,056 were hypermethylated in CD4+ naive T cells from RA PB compared to control PB. In analyses of a second set of CpG candidates based on single-nucleotide polymorphisms from a genome-wide association study of RA, 1 significantly hypermethylated CpG in CD4+ memory T cells and 18 significant CpGs (6 hypomethylated, 12 hypermethylated) in CD4+ naive T cells were found. A prediction score based on the hypermethylated FLS candidates had an area under the curve of 0.73 for association with RA case status, which compared favorably to the association of RA with the HLA-DRB1 shared epitope risk allele and with a validated RA genetic risk score.ConclusionFLS-representative DNA methylation signatures derived from the PB may prove to be valuable biomarkers for the risk of RA or for disease status

Breast Cancer Assessment With Pulse-Echo Speed of Sound Ultrasound From Intrinsic Tissue Reflections: Proof-of-Concept

PURPOSE The aim of this study was to differentiate malignant and benign solid breast lesions with a novel ultrasound (US) technique, which measures speed of sound (SoS) using standard US transducers and intrinsic tissue reflections and scattering (speckles) as internal reference. MATERIALS AND METHODS This prospective, institutional review board-approved, Health Insurance Portability and Accountability Act-compliant prospective comparison study was performed with prior written informed consent from 20 women. Ten women with histological proven breast cancer and 10 with fibroadenoma were measured. A conventional US system with a linear probe was used for SoS-US (SonixTouch; Ultrasonix, Richmond, British Columbia, Canada). Tissue speckle reflections served as a timing reference for the US signals transmitted through the breasts. Relative phase inconsistencies were detected using plane wave measurements from different angular directions, and SoS images with 0.5-mm resolution were generated using a spatial domain reconstruction algorithm. The SoS of tumors were compared with the breast density of a larger cohort of 106 healthy women. RESULTS Breast lesions show focal increments ΔSoS (meters per second) with respect to the tissue background. Peak ΔSoS values were evaluated. Breast carcinoma showed significantly higher ΔSoS than fibroadenomas ([INCREMENT]SoS > 41.64 m/s: sensitivity, 90%; specificity, 80%; area under curve, 0.910) and healthy breast tissue of different densities (area under curve, 0.938; sensitivity, 90%; specificity, 96.5%). The lesion localization in SoS-US images was consistent with B-mode imaging and repeated SoS-US measurements were reproducible. CONCLUSIONS Using SoS-US, based on conventional US and tissue speckles as timing reference, breast carcinoma showed significantly higher SoS values than fibroadenoma and healthy breast tissue of different densities. The SoS presents a promising technique for differentiating solid breast lesions

Impact of Breathing Phase, Liver Segment, and Prandial State on Ultrasound Shear Wave Speed, Shear Wave Dispersion, and Attenuation Imaging of the Liver in Healthy Volunteers

OBJECTIVES: Measurement location and patient state can impact noninvasive liver assessment and change clinical staging in ultrasound examinations. Research into differences exists for Shear Wave Speed (SWS) and Attenuation Imaging (ATI), but not for Shear Wave Dispersion (SWD). The aim of this study is to assess the effect of breathing phase, liver lobe, and prandial state on SWS, SWD, and ATI ultrasound measurements. METHODS: Two experienced examiners performed SWS, SWD, and ATI measurements in 20 healthy volunteers using a Canon Aplio i800 system. Measurements were taken in the recommended condition (right lobe, following expiration, fasting state), as well as (a) following inspiration, (b) in the left lobe, and (c) in a nonfasting state. RESULTS: SWS and SWD measurements were strongly correlated (r = 0.805, p < 0.001). Mean SWS was 1.34 ± 0.13 m/s in the recommended measurement position and did not change significantly under any condition. Mean SWD was 10.81 ± 2.05 m/s/kHz in the standard condition and significantly increased to 12.18 ± 1.41 m/s/kHz in the left lobe. Individual SWD measurements in the left lobe also had the highest average coefficient of variation (19.68%). No significant differences were found for ATI. CONCLUSION: Breathing and prandial state did not significantly affect SWS, SWD, and ATI values. SWS and SWD measurements were strongly correlated. SWD measurements in the left lobe showed a higher individual measurement variability. Interobserver agreement was moderate to good