Girl meets girl: sexual sitings in lesbian romantic comedies

Hollywood romantic comedies are, by and large, an ideologically conservative genre. Based around gender stereotypes and the idealised pursuit, however disguised, of heteropatriarchal monogamy, Hollywood romantic comedies offer countless variations of heteronormative ‘intimacy’. How, then, does the shift from ‘boy meets girl’ to ‘girl meets girl’ in lesbian romantic comedies—a genre that emerged in 1994 with the release of films like Bar Girls and Go Fish—effect the representation of intimacy? This chapter focuses on Better than Chocolate to investigate how lesbian intimacies, and lesbian sex in particular, occupy space. Where are lesbian intimacies sited and what, if any, negotiations of space are triggered through the embodiment of those intimacies? Ultimately, this chapter argues that through an unusually explicit emphasis on sex, Better than Chocolate draws attention to the limited public mobility of lesbian intimacies through a consistent siting of lesbian sex as a site of spatial negotiation

Imaging Pulmonary NF-kappaB Activation and Therapeutic Effects of MLN120B and TDZD-8

NF-κB activation is a critical signaling event in the inflammatory response and has been implicated in a number of pathological lung diseases. To enable the assessment of NF-κB activity in the lungs, we transfected a luciferase based NF-κB reporter into the lungs of mice or into Raw264.7 cells in culture. The transfected mice showed specific luciferase expression in the pulmonary tissues. Using these mouse models, we studied the kinetics of NF-κB activation following exposure to lipopolysaccharide (LPS). The Raw264.7 cells expressed a dose-dependent increase in luciferase following exposure to LPS and the NF-κB reporter mice expressed luciferase in the lungs following LPS challenge, establishing that bioluminescence imaging provides adequate sensitivity for tracking the NF-κB activation pathway. Interventions affecting the NF-κB pathway are promising clinical therapeutics, thus we further examined the effect of IKK-2 inhibition by MLN120B and glycogen synthase kinase 3 beta inhibition by TDZD-8 on NF-κB activation. Pre-treatment with either MLN120B or TDZD-8 attenuated NF-κB activation in the pulmonary tissues, which was accompanied with suppression of pro-inflammatory chemokine MIP-1ß and induction of anti-inflammatory cytokine IL-10. In summary, we have established an imaging based approach for non-invasive and longitudinal assessment of NF-κB activation and regulation during acute lung injury. This approach will potentiate further studies on NF-κB regulation under various inflammatory conditions

Reel to real: Gender, genre, and the Hollywood romantic comedy

This study examines the Hollywood romantic comedy in the context of gender and genre. Utilizing a variety of methodologies, it identifies the generic conventions, inventions, and interventions within Hollywood romantic comedy texts that: (1) affirm patriarchal ideology, (2) challenge patriarchal ideology, and (3) both affirm and challenge patriarchal ideology. Furthermore, through a content, textual, and historical analysis of the top 100 Hollywood romantic comedy texts produced between 1970-1995, it demonstrates how the Hollywood romantic comedy has cycled between progress and backlash in its depictions of, and attitudes toward, American women. During the 1970s, the Hollywood romantic comedy exploited its ideological contradictions in order to challenge traditional gender roles and sexual hierarchies. In the 1980s and 1990s, the Hollywood romantic comedy reversed course, containing its ideological contradictions in order to reinforce traditional gender roles and sexual hierarchies. In a final analysis, this study concludes that the Hollywood romantic comedy neither intrinsically affirms patriarchal ideology nor radically rejects it. Rather, it both affirms and rejects patriarchal ideology, and the key to decoding its practices of signification rests in deciphering how it manages to balance its ideological contradictions, and in exploring the specific historical conditions that can--and do--occasionally tip that balance

The Pricing of Academic Journals

In this paper we investigate the claim that academic journals are too expensive. We estimate library demand for academic journals and ask if short run profit maximization by publishers can explain observed prices. Libraries purchase a portfolio of journals so to estimate demand we extend the standard discrete choice model, and estimation methods, to allow for a choice consisting of a subset of a larger set of journals. Unlike the discrete choice model, the model allows for both positive and negative cross-price effects. We estimate the model using library holdings data and find that on average prices in the industry are lower than what static pricing models predict. Furthermore, we simulate the effects of mergers and find that the likely unilateral effect of a merger is to lower prices

THE PRICING OF ACADEMIC JOURNALS

In this paper we investigate the claim that academic journals are too expensive. We estimate library demand for academic journals and ask if short run profit maximization by publishers can explain observed prices. Libraries purchase a portfolio of journals so to estimate demand we extend the standard discrete choice model, and estimation methods, to allow for a choice consisting of a subset of a larger set of journals. Unlike the discrete choice model, the model allows for both positive and negative cross-price effects. We estimate the model using library holdings data and find that on average prices in the industry are lower than what static pricing models predict. Furthermore, we simulate the effects of mergers and find that the likely unilateral effect of a merger is to lower prices