18,883 research outputs found
Global monopole, dark matter and scalar tensor theory
In this article, we discuss the space-time of a global monopole field as a
candidate for galactic dark matter in the context of scalar tensor theory.Comment: 8 pages, Accepted in Mod. Phys. Lett.
Occultation analysis of BATSE data: Operational aspects
The Burst and Transient Source Experiment (BATSE) large area detectors are being used to monitor hard x-ray/gamma ray sources on a daily basis for evidence of transient behavior. Flux measurements are performed using a simple earth occultation technique. Daily searches are also being performed to detect occultation steps of sources which are not being routinely monitored. Topics concerning the operational aspects of the occultation measurements are presented. Preliminary spectral results are also presented for several of the brighter sources
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Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling.
Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We used integrative molecular profiling to discover and characterize molecular subtypes of LMS. Gene expression profiling was performed on 51 LMS samples. Unsupervised clustering showed three reproducible LMS clusters. Array comparative genomic hybridization (aCGH) was performed on 20 LMS samples and showed that the molecular subtypes defined by gene expression showed distinct genomic changes. Tumors from the muscle-enriched cluster showed significantly increased copy number changes (P=0.04). A majority of the muscle-enriched cases showed loss at 16q24, which contains Fanconi anemia, complementation group A, known to have an important role in DNA repair, and loss at 1p36, which contains PRDM16, of which loss promotes muscle differentiation. Immunohistochemistry (IHC) was performed on LMS tissue microarrays (n=377) for five markers with high levels of messenger RNA in the muscle-enriched cluster (ACTG2, CASQ2, SLMAP, CFL2 and MYLK) and showed significantly correlated expression of the five proteins (all pairwise P<0.005). Expression of the five markers was associated with improved disease-specific survival in a multivariate Cox regression analysis (P<0.04). In this analysis that combined gene expression profiling, aCGH and IHC, we characterized distinct molecular LMS subtypes, provided insight into their pathogenesis, and identified prognostic biomarkers
Jet substructure as a new Higgs search channel at the LHC
It is widely considered that, for Higgs boson searches at the Large Hadron
Collider, WH and ZH production where the Higgs boson decays to b anti-b are
poor search channels due to large backgrounds. We show that at high transverse
momenta, employing state-of-the-art jet reconstruction and decomposition
techniques, these processes can be recovered as promising search channels for
the standard model Higgs boson around 120 GeV in mass.Comment: 4 pages, 3 figure
The stellar velocity dispersion in the inner 1.3 disk scale-lengths of the irregular galaxy NGC 4449
We present measurements of the stellar velocity dispersion in the inner 1
arcmin radius (1.3 disk scale-lengths) of the irregular galaxy NGC 4449
determined from long-slit absorption-line spectra. The average observed
dispersion is 29 +/-2 km/s, the same as predicted from NGC 4449's luminosity.
No significant rotation in the stars is detected. If we assume a maximum
rotation speed of the stars from the model determined from the gas kinematics
of Hunter et al. (2002), the ratio V_max/sigma_z measured globally is 3. This
ratio is comparable to values measured in spiral galaxies, and implies that the
stellar disk in NGC 4449 is kinematically relatively cold. The intrinsic
minor-to-major axis ratio (b/a)_0 is predicted to be in the range 0.3-0.6,
similar to values derived from the distribution of observed b/a of Im galaxies.
However, V/sigma_z measured locally is 0.5-1.1, and so the circular velocity of
NGC 4449 is comparable or less than the velocity of the stars within the
central 1.3 disk scale-lengths of the galaxy.Comment: To be published in ApJ, Nov 200
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