Static versus dynamic loads as an influence on bone remodelling

Bone remodelling activity in the avian ulna was assessed under conditions of disuse alone, disuse with a superimposed continuous compressive load, and disuse interrupted by a short daily period of intermittent loading. The ulna preparation is made by two submetaphyseal osteotomies, the cut ends of the bone being covered with stainless steel caps which, together with the bone they enclosed, are pierced by pins emerging transcutaneously on the dorsal and ventral surfaces of the wing. The 110 mm long undisturbed section of the bone shaft can be protected from functional loading, loaded continuously in compression by joining the pins with springs, or loaded intermittently in compression by engaging the pins in an Instron machine. Similar loads (525 n) were used in both static and dynamic cases engendering similar peak strains at the bone's midshaft (-2000 x 10-6). The intermitent load was applied at a frequency of 1 Hz during a single 100 second period per day as a ramped square wave, with a rate of change of strain during the ramp of 0.01 per second

Control of bone remodelling by applied dynamic loads

The data showing the relationship between bone mass and peak strain magnitude prepared and submitted for publication. The data from experiments relating remodelling activity with static or dynamic loads were prepared and submitted for publication. Development of programs to relate the location of remodelling activity with he natural and artificial dynamic strain distributions continued. Experiments on the effect of different strain rates on the remodelling response continued

Visualization of hydrogen injection in a scramjet engine by simultaneous PLIF imaging and laser holographic imaging

Flowfield characterization has been accomplished for several fuel injector configurations using simultaneous planar laser induced fluorescence (PLIF) and laser holographic imaging (LHI). The experiments were carried out in the GASL-NASA HYPULSE real gas expansion tube facility, a pulsed facility with steady test times of about 350 microsec. The tests were done at simulated Mach numbers 13.5 and 17. The focus of this paper is on the measurement technologies used and their application in a research facility. The HYPULSE facility, the models used for the experiments, and the setup for the LHI and PLIF measurements are described. Measurement challenges and solutions are discussed. Results are presented for experiments with several fuel injector configurations and several equivalence ratios

Disconnected and unplugged: experiences of technology induced anxieties and tensions while traveling

The purpose of this study is to explore the experience of being disconnected while traveling for technologically savvy travelers. This paper will explore how new technologies ‘separate’ travelers from the physical and embodied travel experience, and how experiences and tensions caused by being disconnected or unplugged are negotiated. For this study, travelers’ experiences were elicited through a series of online interviews conducted primarily through email and Facebook. Pearce and Gretzel (2012)’s technology-induced tensions and recent literature on internet/technology addiction provide a conceptual framework for the analysis

The Stellar and Gas Kinematics of Several Irregular Galaxies

We present long-slit spectra of three irregular galaxies from which we determinethe stellar kinematics in two of the galaxies (NGC 1156 and NGC 4449) and ionized-gas kinematics in all three (including NGC 2366). We compare this to the optical morphology and to the HI kinematics of the galaxies. In the ionized gas, we see a linear velocity gradient in all three galaxies. In NGC 1156 we also detect a weak linear velocity gradient in the stars of (5+/-1/sin i) km/s/kpc to a radius of 1.6 kpc. The stars and gas are rotating about the same axis, but this is different from the major axis of the stellar bar which dominates the optical light of the galaxy. In NGC 4449 we do not detect organized rotation of the stars and place an upper limit of (3/sin i) km/s/kpc to a radius of 1.2 kpc. For NGC 4449, which has signs of a past interaction with another galaxy, we develop a model to fit the observed kinematics of the stars and gas. In this model the stellar component is in a rotating disk seen nearly face-on while the gas is in a tilted disk with orbits whose planes precess in the gravitational potential. This model reproduces the apparent counter-rotation of the inner gas of the galaxy. The peculiar orbits of the gas are presumed due to acquisition of gas in the past interaction.Comment: To be published in ApJ, November 20, 200

Quantum Nonlocality: Not Eliminated by the Heisenberg Picture

It is argued that the Heisenberg picture of standard quantum mechanics does not save Einstein locality as claimed in Deutsch and Hayden (2000). In particular, the EPR-type correlations that DH obtain by comparing two qubits in a local manner are shown to exist before that comparison. In view of this result, the local comparison argument would appear to ineffective in supporting their locality claim.Comment: Final version; to appear in Foundations of Physic

On the galactic rotation curves problem within an axisymmetric approach

In U. Nucamendi et al. Phys. Rev. D63 (2001) 125016 and K. Lake, Phys. Rev. Lett. 92 (2004) 051101 it has been shown that galactic potentials can be kinematically linked to the observed red/blue shifts of the corresponding galactic rotation curves under a minimal set of assumptions: the emitted photons come from stable timelike circular geodesic orbits of stars in a static spherically symmetric gravitational field, and propagate to us along null geodesics. It is remarkable that this relation can be established without appealing at all to a concrete theory of gravitational interaction. Here we generalize this kinematical spherically symmetric approach to the galactic rotation curves problem to the stationary axisymmetric realm since this is precisely the symmetry that spiral galaxies possess. Thus, by making use of the most general stationary axisymmetric metric, we also consider stable circular orbits of stars that emit signals which travel to a distant observer along null geodesics and express the galactic red/blue shifts in terms of three arbitrary metric functions, clarifying the contribution of the rotation as well as the dragging of the gravitational field. This stationary axisymmetric approach distinguishes between red and blue shifts emitted by circularly orbiting receding and approaching stars, respectively, even when they are considered with respect to the center of a spiral galaxy, indicating the need of precise measurements in order to confront predictions with observations. We also point out the difficulties one encounters in the attempt of determining the metric functions from observations and list some possible strategies to overcome them.Comment: 7 pages in latex (MNRAS format), no figures, discussion and references adde

Clinical impact of double protease inhibitor boosting with Lopinavir/Ritonavir and Amprenavir as part of salvage antiretroviral therapy

Purpose: Double protease inhibitor (PI) boosting is being explored as a new strategy in salvage antiretroviral (ARV) therapy. However, if a negative drug interaction leads to decreased drug levels of either or both PIs, double PI boosting could lead to decreased virologic response. A negative drug interaction has been described between amprenavir (APV) and lopinavir/ritonavir (LPV/r). This observational cohort study assessed the virologic impact of the addition of APV to a salvage ARV regimen, which also contains LPV/r, compared to a regimen containing LPV/r alone. Method: Patients initiated on a salvage ARV regimen that included LPV/r obtained from the expanded access program in Toronto, Canada, were evaluated. APV (600-1,200 mg bid) was added at the discretion of the treating physician. Results: Using multivariate Cox proportional hazards models, we found that the addition of APV to a LPV/r-containing salvage regimen was not significantly associated with time to virologic suppression (< 50 copies/mL; adjusted hazard ratio [HR] = 0.75, p = .12) or with time to virologic rebound (adjusted HR = 1.46, p = .34). Those patients who received higher doses of APV had an increased chance of virologic suppression (p = .03). In a subset of 27 patients, the median LPV Ctrough was significantly lower in patients receiving APV (p = .04), and the median APV Ctrough was reduced compared to reported controls. Conclusion: Our data do not support an additional benefit in virologic reduction of double boosting with APV and LPV/r relative to LPV/r alone in salvage ARV therapy. Our study's limitations include its retrospective nature and the imbalance between the two groups potentially confounding the results. Although these factors were adjusted for in the multivariate analysis, a prospective randomized controlled trial is warranted to confirm our findings

12^{12}C/13^{13}C ratio in planetary nebulae from the IUE archives

We investigated the abundance ratio of $^{12}$C/$^{13}$C in planetary nebulae by examining emission lines arising from \ion{C}{3} 2s2p ^3P_{2,1,0} \to 2s^2 ^1S_0. Spectra were retrieved from the International Ultraviolet Explorer archives, and multiple spectra of the same object were coadded to achieve improved signal-to-noise. The $^{13}$C hyperfine structure line at 1909.6 \AA was detected in NGC 2440. The $^{12}$C/$^{13}$C ratio was found to be $\sim4.4\pm$1.2. In all other objects, we provide an upper limit for the flux of the 1910 \AA line. For 23 of these sources, a lower limit for the $^{12}$C/$^{13}$C ratio was established. The impact on our current understanding of stellar evolution is discussed. The resulting high signal-to-noise \ion{C}{3} spectrum helps constrain the atomic physics of the line formation process. Some objects have the measured 1907/1909 flux ratio outside the low-electron density theoretical limit for $^{12}$C. A mixture of $^{13}$C with $^{12}$C helps to close the gap somewhat. Nevertheless, some observed 1907/1909 flux ratios still appear too high to conform to the presently predicted limits. It is shown that this limit, as well as the 1910/1909 flux ratio, are predominantly influenced by using the standard partitioning among the collision strengths for the multiplet $^1S_0$--$^3P_J$ according to the statistical weights. A detailed calculation for the fine structure collision strengths between these individual levels would be valuable.Comment: ApJ accepted: 19 pages, 3 Figures, 2 Table

Bar imprints on the inner gas kinematics of M33

We present measurements of the stellar and gaseous velocities in the central 5' of the Local Group spiral M33. The data were obtained with the ARC 3.5m telescope. Blue and red spectra with resolutions from 2 to 4\AA covering the principal gaseous emission and stellar absorption lines were obtained along the major and minor axes and six other position angles. The observed radial velocities of the ionized gas along the photometric major axis of M33 remain flat at ~22 km s^{-1} all the way into the center, while the stellar velocities show a gradual rise from zero to 22 km s^{-1} over that same region. The central star cluster is at or very close to the dynamical center, with a velocity that is in accordance with M33's systemic velocity to within our uncertainties. Velocities on the minor axis are non-zero out to about 1' from the center in both the stars and gas. Together with the major axis velocities, they point at significant deviations from circular rotation. The most likely explanation for the bulk of the velocity patterns are streaming motions along a weak inner bar with a PA close to that of the minor axis, as suggested by previously published IR photometric images. The presence of bar imprints in M33 implies that all major Local Group galaxies are barred. The non-circular motions over the inner 200 pc make it difficult to constrain the shape of M33's inner dark matter halo profile. If the non-circular motions we find in this nearby Sc galaxy are present in other more distant late-type galaxies, they might be difficult to recognize.Comment: 20 pages, 12 figures, ApJ in pres