An appraisal of the cradle-to-gate energy demand and carbon footprint of high-speed steel cutting tools

The awareness of the environmental impact of the manufacturing sector has increased over the last few decades. This paper presents the results of an LCA-based approach used to evaluate the production of a threading tool (i.e., an M10 × 1.25 spiral point tap) made of high-speed steel. The cumulative energy demand and CO2-equivalent emissions have been quantified throughout the entire tool manufacturing process. Both the pre-manufacturing steps and the upstream/downstream flows of the used material have been accounted for, considering cradle-to-gate (plus end-of-life) system boundaries. The results show that the share of primary energy employed to produce the tool is mainly imputable to the manufacturing processes. Therefore, this analysis could contribute to fostering the development of structured assessment frameworks that would allow cutting tool manufacturers to identify the weak points of their production routes to be optimized

Gold(i) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition

Gold(I) complexes of imidazole and thiazole-based diphos type ligands were prepared and their potential as chemotherapeutics investigated. Depending on the ligands employed and the reaction conditions complexes [L(AuCl)2] and [L2Au]X (X = Cl, PF6) are obtained. The ligands used are diphosphanes with azoyl substituents R2P(CH2)2PR2 {R = 1-methylimidazol-2-yl (1), 1-methylbenzimidazol-2-yl (4), thiazol-2-yl (5) and benzthiazol-2-yl (6)} as well as the novel ligands RPhP(CH2)2PRPh {R = 1-methylimidazol-2-yl (3)} and R2P(CH2)3PR2 {R = 1-methylimidazol-2-yl (2)}. The cytotoxic activity of the complexes was assessed against three human cancer cell lines and a rat hepatoma cell line and correlated to the lipophilicity of the compounds. The tetrahedral gold complexes [(3)2Au]PF6 and [(5)2Au]PF6 with intermediate lipophilicity (logD7.4 = 0.21 and 0.25) showed significant cytotoxic activity in different cell lines. Both compounds induce apoptosis and inhibit the enzymes thioredoxin reductase and glutathione reductase

Usefulness of negative supine bicycle exercise stress echocardiography in patients with end stage renal disease evaluated for renal transplantation

Usefulness of negative supine bicycle exercise stress echocardiography in patients with end stage renal disease evaluated for renal transplantatio

Valutazione sperimentale dei livelli di mercurio, cadmio e piombo in alcuni componenti dell'ecosistema marino italiano

SIGLEITItal

Luminescent Alkyne-Bearing Terbium(III) Complexes and Their Application to Bioorthogonal Protein Labeling

Two new bifunctional macrocyclic chelate ligands that form luminescent terbium(III) complexes featuring an alkyne group for conjugation to (bio)molecules via the Cu(I)-catalyzed “click” reaction were synthesized. Upon ligation, the complexes exhibit a significant luminescent enhancement when excited at the λmax of the “clicked” products. To demonstrate the utility of the complexes for luminescent labeling, they were conjugated in vitro to E. coli aspartate/glutamate-binding protein incorporating a genetically encoded p-azido-l-phenylalanine or p-(azidomethyl)-l-phenylalanine residue. The complexes may prove useful for time-gated assay applications